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Faculty
Friedbert Weiss
Professor
Department of Molecular and Integrative Neurosciences
TSRI - 1986
Education
Ph.D. University of California, Santa Barbara, 1986
Awards & Activities
Fellow: American College of Neuropsychopharmacology (ACNP); American Psychological Association (APA; Division 28: Psychopharmacology & Substance Abuse); NIDA MERIT Award, 2004; Editorial Board, Pharmacology, Biochemistry & Behavior
Research Focus
Neurobiology of Drug and Alcohol Addiction
Work in our laboratory is concerned with the neurobiological basis of abnormal behavioral and brain functions relevant to human psychopathology with emphasis on the neural control of motivation and reinforcement. At the present time this work is directed in particular at the understanding of the neurochemical and neuroendocrine basis of drug and alcohol addiction including mechanisms that lead to dependence and withdrawal states, drug craving, and relapse.
Selected References
Weiss, F. and Porrino, L. Minireview -- Behavioral neurobiology of alcohol addiction: Recent advances and challenges. The Journal of Neuroscience 22:3332-3337, 2002.
Liu, X. and Weiss, F. Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of CRF and opioid mechanisms. The Journal of Neuroscience RC 22:7856-7861, 2002.
Ciccocioppo, R., Martin-Fardon, R., and Weiss, F. Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking. Nature Neuroscience 7:495-496, 2004.
Baptista, M.A.S., Martin-Fardon, R., and Weiss, F. Preferential effects of the mGlu2/3 receptor agonist, LY379268, on conditioned reinstatement vs. primary reinforcement: Comparison between cocaine and a potent non-drug reinforcer. The Journal of Neuroscience RC 24:4723-4727, 2004.
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