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Faculty
Michael Oldstone
Professor
Immunology and Microbial Science
TSRI - 1966
Joint Appointments Adjunct Professor, Scripps Florida, Department of Infectology
Education
M.D., University of Maryland School of Medicine, 1961;
M.D./Ph.D Program., Johns Hopkins McCullom Pratt Institute of Biochemistry
Awards & Activities
National Academy of Sciences, 2008
Member, National Academy of Sciences, Institute of Medicine, 1996
Pioneer in NeuroVirology Award, International Society for NeuroVirology, 2003
R.E. Dyer Lectureship and Directors Award (NIH) (contributions in viral pathogenesis, 2000
J. Allyn Taylor International Prize in Medicine (host-virus interactions), 1997
Biomedical Science Award, Karolinska Institute, Sweden (contributions virus/autoimmune diseases), 1994
Rous-Whipple Award (contributions in experimental pathology), 1993
Abraham Flexner Award (contributions in biomedical research), 1988
Cotzias Award (contributions in research of CNS), 1986
Burroughs Wellcome Professorship Award to work with J. Skehel, MRC, Mill Hill, UK
Elected Member, Scandinavian Society of Immunology
World Health Organization Committee for the Eradication of Poliomyelitis and Measles Virus
American Association of Physicians
American Clinical and Climatological Association
American Society for Clinical Investigation
Fellow, American Academy of Microbiology
Fellow, American Associaton for the Advancement of Science
Member, National Advisory Committee, The PEW Scholars Program in the Biomedical Sciences
Editor, Virology; Current Topics in Microbiology and Immunology
Editorial Board, Cell:Host Pathogen; Immunity
Research Focus
Viral Pathogenesis
The Viral-Immunobiology Laboratory, under the direction of Michael Oldstone, is interested in understanding the molecular basis of how viruses infect cells, how the immune response aborts viruses, how viruses wrestle control away from the immune system to establish persistent infections, how persistent infection is initiated and maintained, and the mechanism of how such infections cause disease. Because viruses have different lifestyles, our studies focus on lessons taught primarily to three negative-strand viruses, lymphocytic choriomeningitis, measles and influenza viruses, and their interactions with the host's immune, nervous, and pulmonary system. The laboratory is also involved in prion disease pathogenesis.
Selected References
Brooks, D.G., A.M. Lee, H. Elsaesser, D.B. McGavern and M.B.A. Oldstone. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J. Exp. Med. 205:533-541, 2008.
Trifilo, M.J., T. Yajima, Y. Gu, N. Dalton, K.L. Peterson, R.E. Race, K. Meade-White, J.L. Portis, E. Masliah, K.U. Knowlton, B. Chesebro and M.B.A. Oldstone. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science 313:94-97, 2006.
Kanagawa, M., F. Saito, S. Kunz, T. Yoshida-Moriguchi, R. Barresi, Y.M. Kobayashi, J. Muschler, J.P. Dumanski, D.E. Michele, M.B.A. Oldstone and K.P. Campbell. Molecular recognition by LARGE is essential for expression of functional dystroglycan. Cell 117:953-964, 2004.
Cao, W., M.D. Henry, P. Borrow, H. Yamada, J.H. Elder, E.V. Ravkov, S.T. Nichol, R.W. Compans, K.P. Campbell, M.B.A. Oldstone. Identification of a-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science 282:2079-2081, 1998.
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