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Faculty
Thomas Edgington
PROFESSOR EMERITUS
Immunology and Microbial Science
TSRI - 1965
Education
B.A., Stanford University, 1953
M.D., Stanford University, 1957
Research Focus
The theme of our group is the molecular and structural biology of pathogenetic mechanisms of major diseases particularly those of the vascular system. Major advances are being realized in detailed elucidation the coagulation, aka thrombogenic, molecular cascades and the discovery of precise selective molecular interventions based on the structural biology of the involved proteins. Going beyond attenuation of thrombotic disease, the molecular insight has been advanced to therapeutic thrombosis of solid tumors for infarctive eradication. Analysis of in vivo gene display by the vasculature of solid tumors has led to new insight and targets for safe and effective cancer therapy. Lead thereapeutic compounds have been designed and are advancing to clinical trials. We continue to focus on search and discovery science to advance knowledge and solutions based on the molecular maps of pathogenetic processes.
Selected References
EL-Sheikh, A., Liu, C., Huang, H., and Edgington, T.S. A novel vascular endothelial growth factor heparin-binding domain substructure binds to glycosaminoglycans in vivo, and localizes to tumor microvascular endothelium. Cancer Res. 62(23):7118-7123, 2002.
Liu, C., Sun, C., Huang, H., Janda, K., and Edgington, T. Over-expression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 63:2957-2964, 2003.
Huang, H., Norledge, B.V., Liu, C., Olson, A.J., and Edgington, T.S. Selective attenuation of the extrinsic limb of the tissue factor driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor. Biochemistry 42(36):10619-26, 2003.
Liu, C., Dickinson, C., Shobe, J., DoZate, F., Ruf, W., and Edgington, T.S. A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen. Mol. Cancer Therap.3:793-801, 2004
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