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Faculty
Hollis Cline
Professor
Department of Cell Biology
TSRI - 2008
Joint Appointments Department of Chemical Physiology, Scripps Research
Adjunct Professor, UCSD
Adjunct Professor, Cold Spring Harbor LaboratoryEducation
B. A. - Biology, Bryn Mawr College, Bryn Mawr, PA
Ph.D. - Neurobiology, University of California, Berkeley, CA
2000-2008: Charles and Marie Robertson Professor of Neuroscience, Cold Spring Harbor Laboratory
2002-2006: Director of Research, Cold Spring Harbor Laboratory
1998-2008: Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
1997-1998: Associate Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
1994-1996: Assistant Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
1990-1993: Assistant Professor, Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa
1989-1990: Postdoctoral Fellow, (Advisor: R. Tsien), Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, CA. Calcium imaging in optic tectal cell cultures.
1985-1989: Postdoctoral Fellow, (Advisor: M. Constantine-Paton), Department of Biology, Yale University, New Haven, CT. The role of NMDA receptors in development of the topographic retinotectal projection.
1979-1985: Graduate Student, Neurobiology. UC Berkeley Advisor: G.S.Stent. Thesis: Deelopment of GABAergic Neurons in the Leech
1977-1979: Research Assistant, (A. S. Schnieder) Department of Endocrinology, Sloan Kettering Memorial Cancer Institute
1976-1977: Honors Thesis, Bryn Mawr College. Advisor: D. Prescott. Thesis: Characterization of the high-affinity choline transporter in Manduca sexta.
Awards & Activities
Endowed Chair, Department of Cell Biology, Scripps Research
NIH Director’s Pioneer Award
Associate, Neuroscience Research Program, Neuroscience Institute
Board of Scientific Counselors, NIMH
Director, Neurobiology Course, Marine Biological Laboratory, Woods Hole, MA
Professional MembershipsSociety for Neuroscience, American Academy for the Advancement of Science, American Society for Cell Biology, American Physiological Society
Editorial BoardsFrontiers in Neural Circuits, Journal of Experimental Neuroscience,
Visual Neuroscience, Current Biology, Journal of Developmental Neurobiology, Neural Development
Research Focus
Understanding how experience controls brain development.
My research is focused on understanding the mechanisms by which experience controls the development of the brain. My lab addresses fundamental questions about circuit development, synaptogenesis and plasticity by examining the development of the visual system in Xenopus tadpoles, using in vivo time lapse imaging, combined with both gene transfer and electrophysiological studies of visual system function. We have determined many of the genetic components and cellular mechanisms that are required for the development of brain circuits. These studies provide fundamental information regarding experience-dependent mechanisms of brain development and may provide insight into developmental brain disorders.
Selected References
Thirumalai, V., and Cline, H.T. (2008). Endogenous dopamine suppresses initiation of swimming in pre-feeding zebrafish larvae. J Neurophysiol. 100:1635-1648.
Chiu, S.L., Chen, C.M., and Cline, H.T. (2008). Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58, 708-719.
Bestman, J.E., and Cline, H.T. (2008) The RNA binding protein CPEB controls dendrite growth and neural circuit assembly in vivo. PNAS (in press)
Akerman, CJ, and Cline, H.T. (2007) Refining the roles of GABAergic transmission during neural circuit formation. TINS 30: 382-389.
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