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Faculty
Timothy Jegla
Assistant Professor
Department of Cell Biology
TSRI - 2006
Education
Ph.D. in Neuroscience, Washington University, 1996
Postdoctoral Fellow, Howard Hughes Medical Institute, Stanford University, CA: July 1996 - December 1997
Senior Scientist, Icagen Inc., Research Triangle Park, NC: December 1997 - May 1999
Program Scientist, Head of Molecular Sciences, Icagen Inc., Research Triangle Park, NC: June 1999 - June 2000
Chief Scientist, Head of Molecular Sciences, Icagen Inc., Research Triangle Park, NC: June 2000 – May 2002
Group Leader, Discovery Biology, Genomics Institute of the Novartis Research Foundation, San Diego, CA: June 2002 – August 2006
Assistant Professor, Departments of Biochemistry, The Scripps Research Institute, La Jolla, CA: September 2006-June 2007
Awards & Activities
San Diego Consortium for Systems Biology, Steering Committee
Research Focus
Potassium Channel Function in Neurons
Research in our laboratory aims to define the molecular pathways through which potassium channels regulate neuronal signaling. We use a variety of approaches including electrophysiology, biochemistry, mouse genetics and chemical genomics to explore the neurophysiology of sub-threshold and delayed rectifier potassium channels. These channels are critical determinants of neuronal responsiveness and firing patterns, yet there are still large gaps in our understanding of how the molecular diversity of potassium channel genes corresponds to the physiological diversity of potassium currents in neurons. A secondary interest of the laboratory involves exploring the molecular mechanisms of phototransduction. This research focuses on defining the native signal transduction cascade through which the atypical vertebrate opsin melanopsin transmits information on illumination to the circadian system.
Selected References
Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T. Illumination of the melanopsin signaling pathway. Science. 2005 Jan 28;307(5709):600-4. PMID: 15681390 [PubMed - indexed for MEDLINE]
Viswanath V, Story GM, Peier AM, Petrus MJ, Lee VM, Hwang SW, Patapoutian A, Jegla T. Opposite thermosensor in fruitfly and mouse. Nature. 2003 Jun 19;423(6942):822-3. No abstract available. PMID: 12815418 [PubMed - indexed for MEDLINE]
Wickenden AD, Zou A, Wagoner PK, Jegla T. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol. 2001 Jan;132(2):381-4. PMID: 11159685 [PubMed - indexed for MEDLINE]
Jegla T, Salkoff L. A novel subunit for shal K+ channels radically alters activation and inactivation. J Neurosci. 1997 Jan 1;17(1):32-44. PMID: 8987734 [PubMed - indexed for MEDLINE]
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