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Faculty
William Roush
Professor
Department of Chemistry
TSRI - 2005
Joint Appointments Executive Director, Medicinal Chemistry
Associate Dean, Florida, Graduate Studies
Education
B. S., University of California, Los Angeles 1974
Ph. D., Harvard University 1977
Postdoctoral Fellow, Harvard University 1977-78
Assistant Professor of Chemistry, M.I.T. 1978-83
Associate Professor of Chemistry, M.I.T. 1983-87
Associate Professor of Chemistry, Indiana
University 1987-89
Professor of Chemistry, Indiana University 1989-95
Distinguished Professor of Chemistry, Indiana
University 1995-97
Warner Lambert/Parke-Davis Professor of Chemistry, University of Michigan 1997-2005
Chair, Department of Chemistry, University of
Michigan 2002-2004
Awards & Activities
Fellow of the Alfred P. Sloan Foundation 1982-86
Alan R. Day Award of the Philadelphia Organic Chemist's Club 1992
Arthur C. Cope Scholar Award, American Chemical
Society 1994
ACS Akron Section Award 1996
Merit Award, National Institute of General Medical
Sciences 1998
Distinguished Faculty Achievement Award, University of
Michigan 1999
Paul G. Gassman Distinguished Service Award, ACS Division
of Organic Chemistry 2002
ACS Ernest Guenther Award in the Chemistry of Natural
Products 2004
Secretary-Treasurer, ACS Division of Organic
Chemistry 1990-93
Chairman, ACS Division of Organic Chemistry 1995
Alternate Councilor, ACS Division of Organic
Chemistry 1999-02
NIH Medicinal Chemistry Study Section, Member 1990-93
Chairman, NIH Medicinal Chemistry Study Section 1993-95
Editorial Board, Organic Reactions1991-2002
Board of Directors, Organic Reactions 1995-present
Editorial Board, Encyclopedia of Reagents for Organic
Synthesis 1992-2002
Editorial Board, Organic Syntheses 1993-2002
Board of Directors, Organic Syntheses 2001-present
Consulting Editorial Board, Tetrahedron 1996-2002
Editorial Advisory Board, Organic Letters 1999-present
Associate Editor, Journal of the American Chemical
Society1999-present
Research Focus
The major focus of our research effort concerns the synthesis of stereochemically complex, biologically active natural products. Natural products of considerable current interest include (among others): durhamycin A and B, members of the aureolic acid antibiotic family; angelimicin B, a signal transduction pathway inhibitor; tedanolide, scytophycin C, apoptolidin, and superstolide A -- four structurally complex macrolide antibiotics; quartromicin D, an antiviral agent; and various members of the amphidinolide and Annonaceous acetogenin families. Significant emphasis is placed on the discovery, development, and/or illustration of new reactions and synthetic methods in this research. Some of these synthesis projects involve intramolecular cycloaddition reactions. Others make use of acyclic diastereoselective or enantioselective stereochemical techniques. Still others focus on the development and illustration of new methods for synthesis of glycosides.
We are also pursuing several research programs in bioorganic chemistry, including one focusing on the design and synthesis of inhibitors of cysteine proteases isolated from tropical parasites. This project is performed in collaboration with several groups of scientists at the University of California, San Francisco.
Selected References
W. R. Roush, R. A. Hartz and D. J. Gustin "Total Synthesis of Olivomycin A", J. Am. Chem. Soc., 1999, 121, 1990.
K. A. Scheidt, A. Tasaka, T. D. Bannister, M. D. Wendt, B. M. Savall, G. J. Fegley, and W. R. Roush "Total Synthesis of (-)-Bafilomycin A1," J. Am. Chem. Soc., 2002, 124, 6981.
T. B. Durham, B. M. Savall, N. Blanchard, and W. R. Roush"Total Synthesis of Formamicin," J. Am. Chem. Soc., 2004, 126, 9307.
D. J. Mergott, S. A. Frank, and W. R. Roush"Total Synthesis of (-)-Spinosyn A via Transannular Diels-Alder Reaction/Ring Contraction Sequence," Proc. Natl. Acad. Sci. 2004, 101, 11955.
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