Faculty - Alphabetical
Tabarean, Iustin
Taffe, Michael
investigates the behavioral and physiological impact of exposure to substituted amphetamine drugs of abuse such as 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy) and methamphetamine; he is also studying the cognitive risks posed by chronic alcohol drinking during adolescence.
Tainer, John
develops and applies advanced tools for high-impact structural biology including combined x-ray scattering in solution and x-ray crystallography on complexes at his synchrotron beamline to bridge
from complexes and conformations to pathways and phenotypes by characterizing macromolecular machines, novel inhibitors, and the molecular basis for diseases and intervention strategies.
Tan, Eng
seeks to identify the antibodies involved in autoimmune diseases like lupus and scleroderma, characterize their intracellular antigens, and investigate the relationship of the autoimmune response to disease mechanisms.
Tellinghuisen, Timothy
focuses on understanding the assembly, composition, and activities of the RNA replication machinery of the hepatitis c virus
Teyton, Luc
crystallizes and solves the structures of TCR/pMHC complexes in order to elucidate the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells.
Theofilopoulos, Argyrios
works on the identification of predisposing and effector genes in systemic autoimmunity, as exemplified in spontaneous mouse models of lupus. Both forward (phenotype → genes) and reverse (gene → phenotype) approaches are used and several genes that promote (type I and II IFNs) or suppress (coronin 1A) this disease have thus far been identified.
Thomas, Elizabeth
investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.
Tobias, Peter
focuses on understanding toll-like receptors and the mechanisms by which cells use the innate immune system to detect microbes and initiate defensive inflammatory responses.
Topol, Eric
studies the genome of patients who have particular medical conditions or who have been healthy beyond the 8th decade to determine variants associated with the phenotype. His research moves this information forward in medicine to provide individualization of medical care in the future.
Torbett, Bruce
studies transcriptional regulation of myeloid development and function, develops and tests novel techniques for delivering genes to cells to provide protection against HIV or cancer; he also investigates how the structural changes in HIV protease contribute to biochemical functions that confer protease inhibitor resistance.
Torkamani, Ali
Ulevitch, Richard
studies the innate immune system at the molecular and mechanistic level with an emphasis on its role in the recognition of microbial pathogens.
Unwin, Peter
Valente, Susana
focuses on the discovery and characterization of molecular interactions occurring within a host cell that are critical for HIV replication - the interactions so identified can be tailored to develop therapeutic targets and provide novel antiviral approaches.
Vanderklish, Peter
is looking at how translation in dendrites contributes to the synaptic events that underlie learning and memory.
Vogt, Peter K.
examines mechanisms of oncogenic transformation by transcriptional regulators like Jun, Maf, Qin, FKHR, LEF/TCF, Myc, and Max; studies growth regulatory signals of the Wnt and PI 3-kinase pathways; and screens for anticancer compounds using in vitro and cell-based assays.
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