Faculty - Alphabetical
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Salomon, Daniel
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Sanna, Pietro
is interested in the molecular bases of forms of neural plasticity associated with physiologic events, such as learning, and pathologic events, such as the development of substance dependence.
Sanner, Michel
develops and applies novel computational methods for studying and simulating molecular interactions; areas of research include computer graphics, software development strategies, use of tangible models as a novel human-computer interface for molecular biology, and protein flexibility modeling in docking simulations.
Saphire, Andrew
Saphire, Erica
Please see Ollmann Saphire, Erica
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Scampavia, Louis
works at the high-throughput screening (HTS) robotics facility exploring novel instrumentation and technologies that advance HTS for drug discovery. His work also encompasses the development and transfer of novel biomedical assays for use in HTS campaigns.
Schimmel, Paul
is examining the nature, origins, and boundaries of the genetic code, probing the molecular basis of tRNA specificity and the manipulative potential of tRNAs and their enzymes as tools for developing new proteins, cellular functions, and potential therapeutics.
Schmid, Sandra
is defining the molecular mechanisms of receptor-mediated endocytosis, which involves the concentration of receptor-ligand complexes into clathrin coated pits, their internalization via coated vesicles, and the regulation of these events by GTPases and kinases.
Schneemann, Anette
focuses on the mechanisms of icosahedral viral capsid assembly and RNA packaging as well as the development of viral capsids as nanomaterials.
Schork, Nicholas
focuses on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design, integration, and interpretation of studies making use of contemporary high throughput genomic technologies.
Schroeter, Thomas
focuses on the development and characterization of small molecule kinase inhibitors and predictive toxicology screens to develop potent and safe drug candidates
Schultz, Peter
aims to combine the tools and principles of chemistry with the molecules and processes of living cells to create molecules with new properties and functions found neither in nature nor in the test tube; by studying the structure and function of the resulting molecules, new insights can be gained into the molecular mechanisms of complex biological and chemical systems.
Schweitzer, Paul
focuses on the cellular and molecular mechanisms of action of substances of abuse and their interaction with endogenous transmitter systems in the brain.
Sharpless, K. Barry
discovers new and useful transformations for organic synthesis, particularly employing inorganic catalysts and olefin-derived compounds of high reactivity; he also applies "in situ" click chemistry, which makes enzymes into reaction vessels and templates for the formation of their own inhibitors.
Sherman, Linda
looks at the immune system's basic strategy of discriminating between "self" and "non-self" through T lymphocytes, seeking to augment their ability to respond to certain self-antigens on tumor cells and to diminish their aberrant destruction of self-tissue in autoimmune diseases.
Siggins, George
uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.
Sinha, Subhash
is interested in synthetic methodologies, total synthesis of biologically important natural products and their analogs, antibody catalysis, and the development of prodrug and targeting approaches for cancer therapy.
Sipe, Jack
is currently involved in molecular and experimental studies of endocannabinoid system genetic risk factors for drug abuse, autoimmune disorders and neurological disorders with a specialty in multiple sclerosis.
Siuzdak, Gary
is interested in the design and application of mass spectrometry technology including pulsed laser desorption/ionization from silicon surfaces, understanding virus structure/activity, and metabolite profiling.
Smider, Vaughn
Smith, Roy
focuses on understanding the basis of metabolic diseases and identifying the physiological changes that cause loss of function during aging, including diseases and disorders such as obesity, non-insulin dependent diabetes, atherosclerosis and heart disease, osteoarthritis and neurodegeneration.
Stanfield, Robyn
uses x-ray crystallography to study antibody-antigen complexes in order to better understand the structural aspects of immune recognition.
Stevens, Raymond
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.
Stout, C. David
determines crystal structures of a variety of biological macromolecules, primarily integral membrane associated enzymes and proton pumps, cytochrome P450s, and iron-sulfur enzymes, and including HIV protease mutants, self-assembling peptides, and RNA-protein complexes, in order to understand structure-function relationships and establish mechanism.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Strosberg, Donny
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Surh, Charles
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.
Sutcliffe, J. Gregor
uses molecular biology and animal models to investigate the normal and pathological function of the central nervous system, including disorders such as narcolepsy, schizophrenia, and depression.
Szurmant, Hendrik
is interested in the molecular mechanisms that govern signal
detection and signal transduction in Gram-positive bacteria
applying a combination of computational, structural, biochemical
and genetic approaches.
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