Faculty - Alphabetical
Lasmezas, Corinne
studies the mechanisms of prion propagation and neurotoxicity, and investigates novel approaches to the therapeutics and prophylaxy of prion diseases.
Law, Mansun
Lawson, Brian
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Lee, Jiing-Dwan
applies conditional knockout models to understand the mechanisms of action of the intracellular signaling pathways that are critical for the progression of tumors in humans in order to find molecular targets for cancer prevention and intervention.
Lee, Pauline
Leman, Lucas
Lerner, Richard
studies the development of catalytic antibodies and their application as versatile, molecular tools in such diverse areas as chemical synthesis, drug delivery, and bactericidal action (via the recently discovered water oxidation pathway).
Lesley, Scott
applies high throughput approaches to evaluate protein structural and functional diversity.
Liu, Cheng
Lo Grasso, Philip
studies structure function relationships of enzymes for drug discovery and development.
Loring, Jeanne
Loskutoff, David
is seeking to define the cellular events and interactions (i.e., with vitronectin) that regulate type 1 plasminogen activator inhibitor (PAI-1), key players in the pathogenesis of human vascular disease; he studies the synthesis, secretion, activity, and structure of PAI-1 and vitronectin using cultured cells, murine models of human disease, and human vascular tissue.
Lotz, Martin
examines the aging-associated molecular and cellular changes in bones and joints that result in the clinical signs and pathological symptoms of osteoarthritis, looking for new molecular targets for the diagnosis, prevention, and treatment of this condition; candidates for new osteoarthritis therapies are under evaluation in animals and in clinical trials.
Lu, Xiaoying
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
MacRae, Ian
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Maderazo, Julie
Please see Jameson, Julie
Makarenkova, Elena
Mandyam, Chitra
studies the neurogenic mechanisms altered by complex behavior patterns, including addiction, stress, depression and psychoses with emphasis on understanding the dynamics and mature cell fate of medial prefrontal cortex and hippocampal progenitors that partly maintain the adult medial prefrontal cortex and hippocampal plasticity.
Mason, Barbara
explores the physiological changes in the brain that drive excessive drinking and create vulnerability to relapse, and she investigates the viability of utilizing new compounds to modulate the neurological effects of alcohol, reduce excessive intake, and prevent relapse.
Mauro, Vincent
studies the regulation of gene expression at the level of protein synthesis, focusing on elements that affect translation initiation, including elements contained within mRNAs, such as internal ribosomal entry sites (IRESes), and elements contained within ribosomes, such as ribosomal RNA.
Maximov, Anton
combines genetic, biochemical, optical, and electrophysiological methods
to study synapse development and function in the central nervous system.
Mayford, Mark
uses genetic manipulation to investigate the molecular events involved in learning and memory.
McDonald, Patricia
Focuses on the development of biochemical and cell-based functional assays to identify and develop small molecule modulators of GPCRs for the treatment of metabolic and CNS disorders.
Mc Gowan, Clare
examines the molecular mechanisms and players that regulate the human cell cycle, focusing on DNA damage checkpoints and DNA repair enzymes like Mus81, which resolves strands of duplex DNA that become crossed during replication.
McHeyzer-Williams, Michael G.
studies the cellular and molecular regulation of antigen-specific immune memory in vivo with emphasis on the innate/adaptive interface and helper T cell regulated B cell responses to optimize vaccines.
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Mc Millan, Robert
Micalizio, Glenn
focuses research on the development of new chemical methods and strategies for the total synthesis of complex biologically interesting natural products, and for the discovery of small molecules with interesting biological properties.
Miles, Lindsey
is investigating, at the levels of cellular receptors and gene expression, the regulation of the activity of plasmin, a key protease that regulates pathophysiological processes involving extracellular matrix degradation, tissue remodeling, and cell migration.
Millar, David
uses single-molecule fluorescence and time-resolved laser spectroscopy to study the dynamics of enzyme-DNA interactions and the folding of catalytic RNA molecules.
Miller, Courtney
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Milligan, Ronald
uses cryo-electron microscopy and image analysis to study the structure and mechanism of action of large molecular machines such as actomyosin, kinesin-microtubules, MAPs-microtubles, VCP/p97 and dynein AAA ATPases, various membrane channels and transporters, and bacterial toxins.
Milner, Richard
uses a combination of mouse models and tissue culture cell–based assays to examine the role of fibronectin and endothelial fibronectin receptors in promoting cerebral angiogenesis during cerebral hypoxia and ischemia.
Morris, Kevin
is interested in understanding the mechanism of long antisense non-coding RNA mediated transcriptional regulation in human cells in order to develop small antisense non-coding RNA based approaches to regulate HIV-1 and human cancer.
Mosier, Donald
studies the the basic biology of human immunodeficiency virus (HIV) and its viral dynamics in vivo, looking at how the replication and infectivity of the virus alters with mutations to its genome.
Mosnier, Laurent
Mowen, Kerri
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Murray, Sarah
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