Faculty - Alphabetical
Cameron, Michael
investigates the metabolism of small molecules in vitro and in vivo to evaluate pharmacokinetic and pharmacodynamic properties and potential toxicity.
Carragher, Bridget
is developing, testing, and applying technology for specimen handling, automated acquisition, automated processing, and information handling in electron microscopy; one of the goals is to completely automate cryo-electron microscopy in order to solve macromolecular structures.
Catz, Sergio
Chang, Geoffrey
is interested in the structural basis of the transport of substrate across the cell membrane by ion channels and transporters; he determines the structures of such integral membrane proteins through high-resolution x-ray crystallography.
Chapman, Eli
Cherezov, Vadim Gennadyevich
Cherqui, Stephanie
Chisari, Francis
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Chun, Jerold
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Cleveland, John L.
studies the molecular basis of cancer with a focus on malignancies having myc involvement, which is activated in 70% of all human cancers. Target discovery validation using mouse models, and cancer prevention and therapeutics are the major focuses of the laboratory.
Cline, Hollis
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.
Cochrane, Charles
is involved in studies of the biochemical pathways of injury in the inflammatory process, and has developed a synthetic peptide modeled after surfactant protein B, which is being used for the treatment of pre-term infants, adults with acute lung injury, and patients with acute asthma.
Conkright, Michael
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Conti, Bruno
studies the interaction between the nervous system and the immune system, including the central modulation of immune function and the role of cytokines in the central nervous system; and also investigates the role of core body temperature in regulating energy balance, aging and age-related diseases.
Cook, Boaz
studies sensory processing of mechanical stimuli, from signal transduction in receptor cells to central neuronal networks; using the Drosophila model system to identify mechanosensory genes, study their role and analyze circuitry.
Cooper, Neil
Cravatt, Benjamin
studies the action and regulation of chemical messengers, particularly the fatty acid amides, which mediate physiological phenomena like pain sensation, sleep, and thermoregulation; he designs and uses chemical probes for "active site proteomics," the global analysis of protein function.
Crossin, Kathryn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Cunningham, Bruce
studies the detailed properties of cell surface glycoproteins that play critical roles in neural development, particularly cell adhesion molecules (CAMs), which bind cells together and generate signals that determine a cell's developmental destiny.
Curtiss, Linda
examines the role of innate immunity in atherosclerosis using bone marrow transplantation in models of atherosclerosis.
D'Lima, Darryl
Danuser Andres, Gaudenz
develops image processing software for advanced fluorescence light microscopy and computational models of cytoskeleton mechanics to study the molecular regulation of cell migration and chromosome segregation.
Dawson, Philip
develops novel chemical ligation methodologies for the synthesis of natural and chemically engineered proteins to develop novel peptide based vaccines for HIV-1, study the molecular basis of protein folding and enzymatic catalysis, conjugate biological macromolecules to in complex systems such as cells, viruses and Quantum Dots and to develop synthetic protein pharmaceuticals.
de la Torre, Juan
works on developing novel antiviral strategies against hemorrhagic fever (HF) arenaviruses, which include Lassa fever virus and the South American HF viruses, and studies the mechanisms whereby non-lytic persistent viral infections of the central nervous system cause disturbances in normal brain function.
Deniz, Ashok
develops and uses single-molecule fluorescence methods to study the dynamics and interactions of biological molecules during such processes as protein/RNA folding and assembly of the 30S subunit of the bacterial ribosome.
Der Mardirossian, Celine
Dickerson, Tobin
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Du, Xin
Duckett, Derek
investigates the mechanism of action of small molecule kinase inhibitors with the aim of developing a drug candidate suitable for first time in human studies.
Dyson, Helen Jane
uses NMR to study the protein-folding process and to study the nature and behavior of unfolded and partly folded forms of proteins, including prion proteins and several newly-discovered, intrinsically unstructured proteins.
Edelman, Gerald
examines several areas related to nervous system development and neural function, including cell-cell interactions during embyronic development, the role of cell adhesion molecules in neural plasticity, the molecular genetics of connectional defects in the nervous system, and transcriptional regulation and translational control in eukaryotic cells.
Edgington, Thomas
works on the discovery of pathogenetic pathways, their molecular biology and biochemistry, the identification of target points of intervention for thrombotic and vascular diseases and cancer, and the creation of therapeutic molecules.
Ehlers, Cindy
studies the role genetics plays in the development of addiction to substances in clinical studies and animal models; she also investigates whether genetic, ethnic, and/or racial diversities exist in physiologic markers of risk for substance dependence.
Elder, John
focuses on the molecular and biological characterization of feline immunodeficiency virus (FIV), which causes an AIDS-like disease in the domestic cat and is similar to human immunodeficiency virus (HIV); his goal is to develop drug treatments and vaccines that may be employed to treat viral infections in both humans and cats.
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