Faculty - Alphabetical
Waalen, Jill
Wahlestedt, Claes
is taking a multidisciplinary approach to drug discovery in diseases of the brain (ranging from addiction, pain, affective disorders, Alzheimer's to ADHD), involving aspects of chemistry, pharmacology, behavior, pharmacogenomics, RNA biology and clinical medicine.
Weiss, Friedbert
investigates the neurobiology of addictive disorders, focusing on understanding the brain neurocircuitry as well as the neurochemical and molecular mechanisms that mediate the addictive effects of drugs of abuse, contribute to the development of dependence, and convey vulnerability to relapse.
Weissmann, Charles
elucidates the structure of prions, the mechanism of their replication and the processes by which they enter cells and are released from them.
Wentworth Jr., Paul
investigates the chemistry and biology of reactive oxygen species, particularly of trioxygen species such as ozone, which have recently been shown to be generated by antibodies during bacterial killing and in inflammation; studies the therapeutic potential of designer biocatalysts; and designs novel protein glycoconjugates to generate new strategies for sepsis treatment.
Whitmire, Jason
Whitton, J. Lindsay
studies antiviral immunity mediated by the recognition of viral peptides by host cells, the basis of immunization with plasmid DNA vaccines, and the role of the immune system in viral pathogenesis during coxsackievirus infections.
Wieland, Stefan
studies virus-host interactions during hepatitis B virus infection and the T cell-derived cytokine mediated non-cytopathic mechanisms that inhibit viral replication.
Williamson, Jamie
studies the structure and dynamics of RNA molecules and RNA-protein complexes involved in the regulation of gene expression by employing NMR spectroscopy and X-ray crystallography for solving high-resolution three-dimensional structures and examining the mechanism of assembly of multiprotein-RNA complexes.
Wilson, Curtis
Wilson, Ian
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.
Winzeler, Elizabeth
develops new genome analysis technologies and applies them to study agents of infectious disease, such as the malaria parasite Plasmodium falciparum; her goal is to use genome sequence information, microarrays, and proteomics as a substitute for traditional forward and reverse genetic approaches for elucidation of gene function.
Wiseman, R. Luke
is interested in understanding the cellular and energetic factors that dictate intracellular protein folding as it relates to human disease.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Wright, Peter
uses high-resolution, multi-dimensional, hetero-nuclear magnetic resonance (NMR) spectroscopy to study protein dynamics, folding, and recognition, particularly of structures of protein-DNA and protein-protein complexes involved in the regulation of transcription.
Wu, Xiaohua
studies the molecular mechanisms that regulate DNA repair and cell cycle checkpoint control in mammalian cells with an emphasis on how these activities contribute to the maintenance of genome stability and the prevention of cancer.
Wuthrich, Kurt
develops advanced techniques in nuclear magnetic resonance (NMR) spectroscopy and applies them in protein structural biology and structural genomics projects.
Wyatt, Richard
Xiao, Changchun
studies the functions of microRNA control and its underlying molecular mechanisms in the mammalian immune system, under health and disease conditions.
Yagi, Takao
studies the proton-translocating NADH dehydrogenase (complex I), which, when defective, is involved in many human diseases.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
Yates III, John
develops and applies proteomics tools for analyzing extremely complex protein mixtures, studying host-pathogen interactions in diseases such as malaria, and finding post-translational modifications to the proteins within these same complex mixtures.
Yeager, Mark
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
Yu, Jin-Quan
Discovers regioselective and enantioselective reactions based on C-H activations and applies these reactions to drug discovery and natural product synthesis.
Zhang, Qinghai
Zhou, Bin
Zorrilla, Eric
studies the neurobiology of feeding and stress with special emphasis on neuropeptide mechanisms involved in disorders of energy balance (e.g., obesity) and the regulatory control of appetitive behaviors.
Zwick, Michael
dissects the molecular requirements of neutralization of HIV by antibodies, particularly those against the envelope glycoprotein, gp41; develops strategies for selecting HIV neutralizing antibodies and HIV envelope glycoprotein variants, to inform vaccine design.
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