Faculty - Alphabetical
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Nemerow, Glen
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Nettles, Kendall
researches small molecule ligands, and their interaction with nuclear receptors in the cell’s interior, that may be targets for hormone-driven diseases such as breast and prostate cancers.
Nicolaou, K.C.
works on the total synthesis of biologically active natural and designed molecules and the discovery and development of new synthetic strategies and technologies.
Noodleman, Louis
uses quantum chemistry and protein electrostatics to investigate the electronic structures and active site mechanisms of redox metalloproteins, such as respiratory iron-sulfur proteins, the nitrogen fixing nitrogenase enzyme, and the iron-oxo dimer enzymes methane monooxygenase and ribonucleotide reductase.
Oldstone, Michael
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Ollmann Saphire, Erica
combines x-ray crystallography, biochemistry, and immunology to analyse proteins that play key roles in the pathogenesis of Ebola and other viral hemorrhagic fevers; structures of these proteins provide templates for vaccine design and enable rapid responses to newly emerging forms of the viruses.
Olson, Arthur
develops and applies computational and graphical techniques to the study of biomolecular interactions, focusing on protein-protein recognition and binding in oligomer formation, antibody-antigen complexes, and protein-substrate interactions in drug design.
Ota, Takayuki
Otomo, Takanori
studies structure and function of proteins involved in the autophagic pathway.
Paegel, Brian
studies the controlled synthesis and engineering of phospholipid vesicles and emulsions, microfluidic circuit design, and directed evolution of membrane-associated transporters, pores, and receptors.
Parsons, Loren
studies neurochemical mechanisms in drug dependence with the goal of characterizing neural pathologies that may be viable targets for a pharmacotherapy of addiction; particular focus is on the central serotonin and endocannabinoid systems.
Patapoutian, Ardem
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Paulson, James
studies carbohydrate recognition and the molecular biology of carbohydrate binding proteins, like CD22, which mediate key aspects of cell signaling in the immune system.
Perego, Marta
examines how certain protein structural domains called "tetratricopeptide repeats," which are found in a wide variety of organisms, affect the physiology and reveal the adaptation mechanisms of the gram-positive bacterium Bacillus subtilis.
Periana, Roy
focuses on the design, discovery and study of new coordination catalysts for the selective reaction of strong bonds with the goal of developing new Energy and Material chemistries that is cleaner, lower cost and allows the use of alternative feed stocks.
Petrie, Howard
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Polich, John
uses brainwaves to study human cognitive processes and is especially interested in how common drugs affect these readings.
Pollard, Kenneth
studies how interactions between the environment and genetics affect induction and severity of autoimmune diseases.
Potter, Clinton
is developing, testing, and applying technology for specimen handling, automated acquisition, automated processing, and information handling in electron microscopy; one of the goals is to completely automate cryo-electron microscopy in order to solve macromolecular structures.
Powers, Evan
is interested in the energetics and mechanisms of protein folding and aggregation.
Quigley, James
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Rebek Jr., Julius
studies basic questions of molecular recognition, self-assembly, catalysis, and complementarity by designing novel organic molecular nanocapsules and synthetic receptors.
Reddy, Vijay
Reed, Steven
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Reisfeld, Ralph
explores the use of DNA vaccines and passive immunotherapy, the administration of tumor-specific antigens, as possible ways of preventing and treating cancer.
Reixach, Natalia
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Roberto, Marisa
uses in vitro electrophysiological techniques to understand the effects of abused drugs and neuropeptides on neuronal function and synaptic transmission.
Roberts, Amanda
investigates the neural bases of motivated behaviors such as drug self-administration, exploratory drive, and feeding.
Roberts, Edward
Romesberg, Floyd
seeks to understand and evolve novel protein function by expanding the genetic code, to understand the molecular basis of DNA damage, repair, and mutagenesis, and to use femtosecond laser pulses to probe protein dynamics.
Rosen, Hugh
uses chemical and biological approaches to define and manipulate the molecular gatekeepers regulating cell trafficking in the immune system, including sphingosine 1-phosphate receptors; this work defines links between innate and adaptive immunity and develops novel approaches to immunosuppression that may be therapeutically useful.
Roush, William
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Ruf, Wolfram
studies proteins and signaling mechanisms involved in blood coagulation, angiogenesis, and inflammation in order to understand thrombophilia, hemophilia, cancer, and inflammatory diseases like sepsis.
Ruggeri, Zaverio
investigates the mechanisms involved in normal and pathogenic platelet adhesion and the formation of blood clots.
Russell, Paul
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.
|
