Faculty - Alphabetical
Han, Jiahuai
examines the innate immune system at the molecular and mechanistic level with an emphasis on the intracellular signaling pathways that are activated by pathogens and cytokines.
Hanneken, Anne
explores the ability of flavonoids to prevent oxidative stress and cell death in the retina, with the long-term goal of developing preventative therapies for people at high risk for macular degeneration and blindness.
Harris, Jennifer
Havran, Wendy
studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.
Hedlund, Peter
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Heeb, Mary
examines the biochemistry and mechanism of action of novel anticoagulant molecules like protein Z and protein S, which may be valuable targets for intervention in thrombotic and vascular diseases.
Heyser, Charles
Hoch, James
investigates developmentally programmed gene expression and signal transduction in cellular differentiation.
Hodder, Peter
runs Scripps Research's high-throughput screening (HTS) laboratory. He is focused on implementing & executing HTS assays for pharmaceutical drug discovery as well as managing Scripps Research's HTS compound collection. He also has interest in developing novel HTS-related automation, detection and assay technologies.
Huennekens, Frank
Hwang, Inkyu
investigates cellular mechanisms underlying T cell receptor-mediated integrin activation and develops cell-based high throughput assay systems useful for isolation of small molecules modulating T cell immune functions.
Isogawa, Masanori
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Jameson, Julie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Janda, Kim
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Jegla, Timothy
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Joazeiro, Claudio Antonio
Johnson, Eric
explores the structure, function, and regulation of cytochrome P-450 monooxygenases in order to understand how these diverse enzymes contribute to a person's ability to avoid the adverse effects of environmental chemicals and alter the clearance and bioavailability of therapeutic drugs.
Johnson Jr., John
uses a variety of cellular and molecular biology methods to develop and test atomic resolution models of particle-related events in the virus life cycle; he also uses viruses as a paradigm for developing methods to determine atomic resolution models of cellular mega-structures.
Joyce, Gerald
studies the test-tube evolution of RNA and DNA enzymes, both to explore their potential biomedical applications and to examine their possible role in the early history of life on Earth.
Kamenecka, Theodore
focuses on the design, synthesis and evaluation of novel compounds of biological and therapeutic interest.
Kaufmann, Gunnar Joerg
Keinan, Ehud
Kelly, Jeffery
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Kenny, Paul
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Klinman, Norman
asks how somatically mutated memory B cells are generated and selected, and investigates the mechanisms responsible for B cell development and homeostasis in young and aged mice.
Kodadek, Thomas
focuses his research in the area of chemical biology, deciphering the roles of the proteasome in transcription and understanding the mechanism of action of the hormone orexin.
Kono, Dwight
is investigating the pathogenesis of systemic lupus erythematosus and mercury-induced autoimmunity as well as seeking to identify new potential therapeutic targets through novel approaches; his main interest is to define both predisposing genes and genes critical for disease development.
Koob, George
Investigates the neurobiological basis of emotional behavior focused on the theoretical constructs of reward and stress. His work explores the neural bases of motivation, reinforcement, behavioral responses to stress, and addiction.
Koziol, James
applies mathematics and statistics to solving relevant biomedical problems that range from predicting tumor diagnosis to analyzing past trends in discharge rates in California hospitals.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Kravchenko, Vladimir
Krishnamurthy, Ramanarayanan
seeks to examine the question of why nature selected the building blocks it did to make RNA and uses chemical reasoning to conceive, synthesize, and study alternative nucleic acid structures, like TNA, that could have assembled themselves under natural conditions.
Kuhn, Peter
is developing novel approaches to biophysical characterization of biological systems; applications of these approaches focus on structural proteomics and translational medicine.
Kunicki, Thomas
explores the function, mechanisms of action, and the regulation of human platelet adhesion receptors, which are important in thrombotic and vascular diseases.
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