Faculty - Alphabetical
Fedor, Martha
investigates RNA enzymes using enzymological and biochemical methods to learn how RNAs assemble into functional structures and catalyze biological transformations.
Fee, James
Feeney, Ann
studies the epigenetic and genetic mechanisms that control the accessibility of antibody V, D, and J genes to undergo V(D)J recombination, determining why individual V genes rearrange with very different frequencies, and determining how the generation of the antibody repertoire and B cell tolerance mechanisms are misregulated in murine models of autoimmune disease
Felding-Habermann, Brunhilde
establishes unique models of brain metastasis from circulating tumor cells of breast cancer patients and analyzes their properties in vitro and in vivo, investigates genes and functional pathways that control metastatic activity.
Feng, Yangbo
focuses on the lead identification and optimization of drug candidates.
Finn, M.G.
uses viruses as building blocks for biologically active structures, diagnostic agents, immunogenic platforms, and drug delivery vehicles; and also develops new bioconjugation methods, enzyme inhibitors, and functional materials using "click chemistry," and studies organic and organometallic reaction mechanisms.
Fokin, Valery
develops preactical catalytic transformations for organic synthesis, combinatorial chemistry, chemical biology, and materials research; searches for novel antiviral agents, nicotinic receptor ligands, and protease inhibitors.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Franc, Nathalie
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Friedman, Jeffrey
uses mouse and cell culture models with mutations that affect resistance to oxidative stress to study how oxidants affect blood cell development, immune function, and aging.
Gale, Andrew
investigates Factor VIII and other proteins involved in blood coagulation with the hope of finding improved therapies for hemophilia A.
Gallay, Philippe
looks at the glycoprotein attachment receptors on human cells that enhance the entry of HIV and works toward using those proteins as a guide for drug design.
Gascoigne, Nicholas
examines molecular and genetic interactions in T cell development and activation, including the spatiotemporal analysis of signaling cascades using fluorescence resonance energy transfer (FRET) and other techniques to image molecular interactions in live cells.
Gavin, Amanda
Gekakis, Nicholas
Gerace, Larry
seeks to understand the mechanisms for regulation of signaling and cell differentiation by components of the nuclear envelope, particularly in regard to muscle, and the machinery for posttranscriptional regulation of gene expression by nucleocytoplasmic transport, mRNA translation and protein turnover, with focus on HIV-1.
Getzoff, Elizabeth
aims to characterize functionally important protein conformational states by coupling crystallography, spectroscopy, molecular biology and computational analyses, and to apply that knowledge to protein and inhibitor design for key biological processes, including photoactivity, electron transfer, and enzyme catalysis.
Ghadiri, M.Reza
develops novel methods for the rational design and construction of functional and interesting bioorganic molecules, such as novel antimicrobial agents, catalytic peptides, biosensors, self-replicating systems, and molecular logic gates.
Goodin, David
is focused on the rational engineering of metalloenzyme catalysts in order to better understand the chemical diversity of natural enzymes and to generate novel catalysts of potential utility.
Goodsell Jr., David
combines computer graphics and computational chemistry to study the basic mechanisms of protein structure and function.
Gottesfeld, Joel
is concerned with protein-DNA interactions involved in the transcriptional regulation in animal cells and the development of small molecule inhibitors and activators of gene expression.
Griffin, John
investigates how molecular players like activated protein C contribute to protection against thrombotic diseases, such as ischemic stroke or venous thrombosis, with the hope of finding new therapies that could reduce damage caused by harmful blood clots.
Griffin, Patrick
focuses on the application of mass spectrometry technology to probe protein-ligand and protein-protein interactions.
Gruol, Donna
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Guidotti, Luca
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
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