Faculty - Alphabetical
Ajami, Dariush
Asahara, Hiroshi
is a molecular biologist and orthopedic surgeon who examines the precise mechanism of chromatin-dependent gene regulation, combining new findings in molecular and developmental biology with clinical research in the field of locomotive science to develop innovative new therapies for patients with arthritis, bone tumor and spinal cord injuries.
Asturias, Francisco
studies the structures of macromolecular assemblies involved in eukaryotic gene expression and its control, such as complexes formed by RNA polymerase II and general transcription factors, using the technique of cryoelectron microscopy.
Ayad, Nagi G.
studies the cell biological basis of cell cycle exit and differentiation of neuronal precursors as it relates to cancer and nerve regeneration.
Baccala, Roberto
is studying mechanisms of T-cell homeostasis and associated defects in autoimmunity, focusing on developing new therapies for autoimmune diseases and cancer.
Balch, William E.
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Baldwin, Kristin
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Bannister, Thomas
uses all modern synthesis techniques to help our interdisciplinary Drug Discovery team rapidly design potential drug candidates for treating multiple sclerosis, diabetes, and addiction.
Baran, Phil
explores new avenues for the efficient and practical construction of organic molecules, both naturally occurring and man-made, by pursuing longstanding synthetic challenges and by designing methods of broad utility.
Barbas III, Carlos
designs zinc finger protein-based transcription factors for the directed regulation of gene expression and gene discovery; programs complex reaction mechanisms into antibodies and uses them to treat cancer; develops new approaches to catalytic asymmetric synthesis; and uses phage display methods to evolve antibodies with the potential to become new immunotherapeutic and gene therapeutic approaches to diseases like breast and ovarian cancer, melanoma, and AIDS.
Bartfai, Tamas
directs the Harold L. Dorris Neurological Research Center, which investigates neurological disorders, including schizophrenia and Alzheimer's disease, and which seeks to advance knowledge of the process of aging of the brain.
Beutler, Bruce
searches for genes that are required for normal immune function through germline mutagenesis and positional cloning.
Bloom, Floyd
specializes in the quantitative microscopy of neurons and neurotransmitters and is devoted to devising systems of computer-assisted tools to collect, collate, organize, and analyze the multidimensional data sets that characterize modern neuroscience research.
Boddy, Michael
studies proteins that repair DNA and maintain the integrity of the genome and asks how these repair mechanisms are relevant to cancer and other human diseases.
Boger, Dale
works on the total synthesis of biologically active natural products using the tools of organic synthesis to identify, imitate, understand, exploit, and sometimes surpass what nature provides.
Bohn, Laura
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Bois, Philippe
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Bokoch, Gary
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Burris, Thomas
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Burton, Dennis
focuses his research primarily on human antibody responses to HIV and the design of an HIV vaccine. He has also worked on the interaction of antibodies and other pathogens, including respiratory syncytial virus, Ebola virus and prion proteins.
Busby, Jennifer Ann
is responsible for advancing the use of mass spectrometry and high performance liquid chromatography in the study and analysis of proteins.
Butler, Andrew
focuses on two areas of the neuroendocrine basis of metabolic diseases that are associated with obesity - how signals of energy status regulate circadian rhythms and the function of novel circulating factors that regulate the metabolic adaptation to changes in energy status.
Buxbaum, Joel
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
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