Balch, William
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Elder, John H.
focuses on the molecular and biological characterization of feline immunodeficiency virus (FIV), which causes an AIDS-like disease in the domestic cat and is similar to human immunodeficiency virus (HIV); his goal is to develop drug treatments and vaccines that may be employed to treat viral infections in both humans and cats.
Getzoff, Elizabeth D.
aims to characterize functionally important protein conformational states by coupling crystallography, spectroscopy, molecular biology and computational analyses, and to apply that knowledge to protein and inhibitor design for key biological processes, including photoactivity, electron transfer, and enzyme catalysis.
Ghadiri, M.Reza
develops novel methods for the rational design and construction of functional and interesting bioorganic molecules, such as novel antimicrobial agents, catalytic peptides, biosensors, self-replicating systems, and molecular logic gates.
Goodin, David B.
is focused on the rational engineering of metalloenzyme catalysts in order to better understand the chemical diversity of natural enzymes and to generate novel catalysts of potential utility.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Johnson Jr., John Emil
uses a variety of cellular and molecular biology methods to develop and test atomic resolution models of particle-related events in the virus life cycle; he also uses viruses as a paradigm for developing methods to determine atomic resolution models of cellular mega-structures.
Joyce, Gerald F.
studies the test-tube evolution of RNA and DNA enzymes, both to explore their potential biomedical applications and to examine their possible role in the early history of life on Earth.
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Lesley, Scott A.
applies high throughput approaches to evaluate protein structural and functional diversity.
MacRae, Ian John
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Nemerow, Glen R.
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Nettles, Kendall William
researches small molecule ligands, and their interaction with nuclear receptors in the cell’s interior, that may be targets for hormone-driven diseases such as breast and prostate cancers.
Noodleman, Louis
uses quantum chemistry and protein electrostatics to investigate the electronic structures and active site mechanisms of redox metalloproteins, such as respiratory iron-sulfur proteins, the nitrogen fixing nitrogenase enzyme, and the iron-oxo dimer enzymes methane monooxygenase and ribonucleotide reductase.
Ollmann Saphire, Erica Ollmann
combines x-ray crystallography, biochemistry, and immunology to analyse proteins that play key roles in the pathogenesis of Ebola and other viral hemorrhagic fevers; structures of these proteins provide templates for vaccine design and enable rapid responses to newly emerging forms of the viruses.
Otomo, Takanori
studies structure and function of proteins involved in the autophagic pathway.
Periana, Roy A
focuses on the design, discovery and study of new coordination catalysts for the selective reaction of strong bonds with the goal of developing new Energy and Material chemistries that is cleaner, lower cost and allows the use of alternative feed stocks.
Stevens, Raymond C.
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.
Stout, C. D.
determines crystal structures of a variety of biological macromolecules, primarily integral membrane associated enzymes and proton pumps, cytochrome P450s, and iron-sulfur enzymes, and including HIV protease mutants, self-assembling peptides, and RNA-protein complexes, in order to understand structure-function relationships and establish mechanism.
Tainer, John A.
develops and applies advanced tools for high-impact structural biology including combined x-ray scattering in solution and x-ray crystallography on complexes at his synchrotron beamline to bridge
from complexes and conformations to pathways and phenotypes by characterizing macromolecular machines, novel inhibitors, and the molecular basis for diseases and intervention strategies.
Torbett, Bruce E.
studies transcriptional regulation of myeloid development and function, develops and tests novel techniques for delivering genes to cells to provide protection against HIV or cancer; he also investigates how the structural changes in HIV protease contribute to biochemical functions that confer protease inhibitor resistance.
Williamson, Jamie R.
studies the structure and dynamics of RNA molecules and RNA-protein complexes involved in the regulation of gene expression by employing NMR spectroscopy and X-ray crystallography for solving high-resolution three-dimensional structures and examining the mechanism of assembly of multiprotein-RNA complexes.
Wilson, Ian A.
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
