Ayad, Nagi G.
studies the cell biological basis of cell cycle exit and differentiation of neuronal precursors as it relates to cancer and nerve regeneration.
Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Chun, Jerold Jun Ming
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Cline, Hollis
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.
Cook, Boaz Shay
studies sensory processing of mechanical stimuli, from signal transduction in receptor cells to central neuronal networks; using the Drosophila model system to identify mechanosensory genes, study their role and analyze circuitry.
Cravatt, Benjamin F.
studies the action and regulation of chemical messengers, particularly the fatty acid amides, which mediate physiological phenomena like pain sensation, sleep, and thermoregulation; he designs and uses chemical probes for "active site proteomics," the global analysis of protein function.
Crossin, Kathryn Lynn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Cunningham, Bruce Arthur
studies the detailed properties of cell surface glycoproteins that play critical roles in neural development, particularly cell adhesion molecules (CAMs), which bind cells together and generate signals that determine a cell's developmental destiny.
Edelman, Gerald M.
examines several areas related to nervous system development and neural function, including cell-cell interactions during embyronic development, the role of cell adhesion molecules in neural plasticity, the molecular genetics of connectional defects in the nervous system, and transcriptional regulation and translational control in eukaryotic cells.
Gruol, Donna L.
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Hedlund, Peter B.
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Jegla, Timothy J.
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Kenny, Paul John
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Koob, George F.
Investigates the neurobiological basis of emotional behavior focused on the theoretical constructs of reward and stress. His work explores the neural bases of motivation, reinforcement, behavioral responses to stress, and addiction.
Mauro, Vincent Peter
studies the regulation of gene expression at the level of protein synthesis, focusing on elements that affect translation initiation, including elements contained within mRNAs, such as internal ribosomal entry sites (IRESes), and elements contained within ribosomes, such as ribosomal RNA.
Miller, Courtney Anne
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Patapoutian, Ardem S.
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Roberto, Marisa
uses in vitro electrophysiological techniques to understand the effects of abused drugs and neuropeptides on neuronal function and synaptic transmission.
Sanna, Pietro P.
is interested in the molecular bases of forms of neural plasticity associated with physiologic events, such as learning, and pathologic events, such as the development of substance dependence.
Siggins, George R.
uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.
Stevens, Raymond C.
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Thomas, Elizabeth Anne
investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
