Asahara, Hiroshi
is a molecular biologist and orthopedic surgeon who examines the precise mechanism of chromatin-dependent gene regulation, combining new findings in molecular and developmental biology with clinical research in the field of locomotive science to develop innovative new therapies for patients with arthritis, bone tumor and spinal cord injuries.
Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Chisari, Francis V.
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Chun, Jerold Jun Ming
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Crossin, Kathryn Lynn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Guidotti, Luca G.
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
Hedlund, Peter B.
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Oldstone, Michael B.
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Patapoutian, Ardem S.
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Petrie, Howard T.
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Reed, Steven I.
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Thomas, Elizabeth Anne
investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.
Whitton, J. Lindsay L.
studies antiviral immunity mediated by the recognition of viral peptides by host cells, the basis of immunization with plasmid DNA vaccines, and the role of the immune system in viral pathogenesis during coxsackievirus infections.
