Balch, William
is interested in the biochemical and molecular basis for vesicular trafficking from the endoplasmic reticulum to the cell surface, particularly in the structures, functions, and mechanisms of control exerted by small GTP-binding proteins.
Bohn, Laura Michelle
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Bois, Philippe Roger Jean
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Burris, Thomas P
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Conkright, Michael D.
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Dickerson, Tobin Jarret
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Finn, M.G.
uses viruses as building blocks for biologically active structures, diagnostic agents, immunogenic platforms, and drug delivery vehicles; and also develops new bioconjugation methods, enzyme inhibitors, and functional materials using "click chemistry," and studies organic and organometallic reaction mechanisms.
Fokin, Valery
develops preactical catalytic transformations for organic synthesis, combinatorial chemistry, chemical biology, and materials research; searches for novel antiviral agents, nicotinic receptor ligands, and protease inhibitors.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Gerace, Larry
seeks to understand the mechanisms for regulation of signaling and cell differentiation by components of the nuclear envelope, particularly in regard to muscle, and the machinery for posttranscriptional regulation of gene expression by nucleocytoplasmic transport, mRNA translation and protein turnover, with focus on HIV-1.
Ghadiri, M.Reza
develops novel methods for the rational design and construction of functional and interesting bioorganic molecules, such as novel antimicrobial agents, catalytic peptides, biosensors, self-replicating systems, and molecular logic gates.
Harris, Jennifer Leslie
Hodder, Peter S.
runs Scripps Research's high-throughput screening (HTS) laboratory. He is focused on implementing & executing HTS assays for pharmaceutical drug discovery as well as managing Scripps Research's HTS compound collection. He also has interest in developing novel HTS-related automation, detection and assay technologies.
Hwang, Inkyu
investigates cellular mechanisms underlying T cell receptor-mediated integrin activation and develops cell-based high throughput assay systems useful for isolation of small molecules modulating T cell immune functions.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Janda, Kim D.
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Jegla, Timothy J.
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Joyce, Gerald F.
studies the test-tube evolution of RNA and DNA enzymes, both to explore their potential biomedical applications and to examine their possible role in the early history of life on Earth.
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Lesley, Scott A.
applies high throughput approaches to evaluate protein structural and functional diversity.
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Nemerow, Glen R.
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Oldstone, Michael B.
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Paegel, Brian M
studies the controlled synthesis and engineering of phospholipid vesicles and emulsions, microfluidic circuit design, and directed evolution of membrane-associated transporters, pores, and receptors.
Patapoutian, Ardem S.
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Petrie, Howard T.
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Potter, Clinton S.
is developing, testing, and applying technology for specimen handling, automated acquisition, automated processing, and information handling in electron microscopy; one of the goals is to completely automate cryo-electron microscopy in order to solve macromolecular structures.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Roberts, Amanda J.
investigates the neural bases of motivated behaviors such as drug self-administration, exploratory drive, and feeding.
Romesberg, Floyd Eric
seeks to understand and evolve novel protein function by expanding the genetic code, to understand the molecular basis of DNA damage, repair, and mutagenesis, and to use femtosecond laser pulses to probe protein dynamics.
Roush, William R.
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Scampavia, Louis Daniel
works at the high-throughput screening (HTS) robotics facility exploring novel instrumentation and technologies that advance HTS for drug discovery. His work also encompasses the development and transfer of novel biomedical assays for use in HTS campaigns.
Schroeter, Thomas
focuses on the development and characterization of small molecule kinase inhibitors and predictive toxicology screens to develop potent and safe drug candidates
Siuzdak, Gary E.
is interested in the design and application of mass spectrometry technology including pulsed laser desorption/ionization from silicon surfaces, understanding virus structure/activity, and metabolite profiling.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Strosberg, Donny D.
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Thomas, Elizabeth Anne
investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.
Wilson, Ian A.
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.
Winzeler, Elizabeth A.
develops new genome analysis technologies and applies them to study agents of infectious disease, such as the malaria parasite Plasmodium falciparum; her goal is to use genome sequence information, microarrays, and proteomics as a substitute for traditional forward and reverse genetic approaches for elucidation of gene function.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
Yu, Jin-Quan
Discovers regioselective and enantioselective reactions based on C-H activations and applies these reactions to drug discovery and natural product synthesis.
