Asahara, Hiroshi
is a molecular biologist and orthopedic surgeon who examines the precise mechanism of chromatin-dependent gene regulation, combining new findings in molecular and developmental biology with clinical research in the field of locomotive science to develop innovative new therapies for patients with arthritis, bone tumor and spinal cord injuries.
Bartfai, Tamas
directs the Harold L. Dorris Neurological Research Center, which investigates neurological disorders, including schizophrenia and Alzheimer's disease, and which seeks to advance knowledge of the process of aging of the brain.
Burris, Thomas P
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Buxbaum, Joel N.
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
Chisari, Francis V.
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Elder, John H.
focuses on the molecular and biological characterization of feline immunodeficiency virus (FIV), which causes an AIDS-like disease in the domestic cat and is similar to human immunodeficiency virus (HIV); his goal is to develop drug treatments and vaccines that may be employed to treat viral infections in both humans and cats.
Feng, Yangbo
focuses on the lead identification and optimization of drug candidates.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gale, Andrew
investigates Factor VIII and other proteins involved in blood coagulation with the hope of finding improved therapies for hemophilia A.
Gottesfeld, Joel M.
is concerned with protein-DNA interactions involved in the transcriptional regulation in animal cells and the development of small molecule inhibitors and activators of gene expression.
Guidotti, Luca G.
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
Hanneken, Anne M.
explores the ability of flavonoids to prevent oxidative stress and cell death in the retina, with the long-term goal of developing preventative therapies for people at high risk for macular degeneration and blindness.
Havran, Wendy L.
studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.
Heeb, Mary J.
examines the biochemistry and mechanism of action of novel anticoagulant molecules like protein Z and protein S, which may be valuable targets for intervention in thrombotic and vascular diseases.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Koob, George F.
Investigates the neurobiological basis of emotional behavior focused on the theoretical constructs of reward and stress. His work explores the neural bases of motivation, reinforcement, behavioral responses to stress, and addiction.
Lesley, Scott A.
applies high throughput approaches to evaluate protein structural and functional diversity.
Morris, Kevin Vance
is interested in understanding the mechanism of long antisense non-coding RNA mediated transcriptional regulation in human cells in order to develop small antisense non-coding RNA based approaches to regulate HIV-1 and human cancer.
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Oldstone, Michael B.
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Petrie, Howard T.
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Pollard, Kenneth M.
studies how interactions between the environment and genetics affect induction and severity of autoimmune diseases.
Ruggeri, Zaverio M.
investigates the mechanisms involved in normal and pathogenic platelet adhesion and the formation of blood clots.
Salomon, Daniel R.
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Sipe, Jack C.
is currently involved in molecular and experimental studies of endocannabinoid system genetic risk factors for drug abuse, autoimmune disorders and neurological disorders with a specialty in multiple sclerosis.
Surh, Charles D.
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.
Tan, Eng M.
seeks to identify the antibodies involved in autoimmune diseases like lupus and scleroderma, characterize their intracellular antigens, and investigate the relationship of the autoimmune response to disease mechanisms.
Topol, Eric
studies the genome of patients who have particular medical conditions or who have been healthy beyond the 8th decade to determine variants associated with the phenotype. His research moves this information forward in medicine to provide individualization of medical care in the future.
Torbett, Bruce E.
studies transcriptional regulation of myeloid development and function, develops and tests novel techniques for delivering genes to cells to provide protection against HIV or cancer; he also investigates how the structural changes in HIV protease contribute to biochemical functions that confer protease inhibitor resistance.
Weissmann, Charles
elucidates the structure of prions, the mechanism of their replication and the processes by which they enter cells and are released from them.
