Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Cline, Hollis
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.
Crossin, Kathryn Lynn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Powers, Evan T.
is interested in the energetics and mechanisms of protein folding and aggregation.
Reed, Steven I.
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Wiseman, R. Luke Luke
is interested in understanding the cellular and energetic factors that dictate intracellular protein folding as it relates to human disease.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
