Burris, Thomas P
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Griffin, Patrick Robert
focuses on the application of mass spectrometry technology to probe protein-ligand and protein-protein interactions.
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Lesley, Scott A.
applies high throughput approaches to evaluate protein structural and functional diversity.
MacRae, Ian John
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Noodleman, Louis
uses quantum chemistry and protein electrostatics to investigate the electronic structures and active site mechanisms of redox metalloproteins, such as respiratory iron-sulfur proteins, the nitrogen fixing nitrogenase enzyme, and the iron-oxo dimer enzymes methane monooxygenase and ribonucleotide reductase.
Phinney, Donald G
employs a multi-disciplinary approach to study the basic biology of mesenchymal stem cells and their potential as vectors to treat inflammatory and neurodegenerative disorders.
Siuzdak, Gary E.
is interested in the design and application of mass spectrometry technology including pulsed laser desorption/ionization from silicon surfaces, understanding virus structure/activity, and metabolite profiling.
Stevens, Raymond C.
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
