Chisari, Francis V.
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Dickerson, Tobin Jarret
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Guidotti, Luca G.
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
MacRae, Ian John
combines structural biology, biochemistry and cell biology to understand mechanisms of gene regulation by RNA interference.
Mosier, Donald E.
studies the the basic biology of human immunodeficiency virus (HIV) and its viral dynamics in vivo, looking at how the replication and infectivity of the virus alters with mutations to its genome.
Strosberg, Donny D.
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Tellinghuisen, Timothy Lee
focuses on understanding the assembly, composition, and activities of the RNA replication machinery of the hepatitis c virus
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
