Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Bohn, Laura Michelle
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Cline, Hollis
studies the analysis of the activity-dependent control of cell proliferation, neuronal development and circuit formation in the visual system using gene transfer, in vivo imaging and electrophysiological techniques.
Dickerson, Tobin Jarret
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Gruol, Donna L.
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Hedlund, Peter B.
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Janda, Kim D.
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Kenny, Paul John
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Koob, George F.
Investigates the neurobiological basis of emotional behavior focused on the theoretical constructs of reward and stress. His work explores the neural bases of motivation, reinforcement, behavioral responses to stress, and addiction.
Mandyam, Chitra Dhati
studies the neurogenic mechanisms altered by complex behavior patterns, including addiction, stress, depression and psychoses with emphasis on understanding the dynamics and mature cell fate of medial prefrontal cortex and hippocampal progenitors that partly maintain the adult medial prefrontal cortex and hippocampal plasticity.
Mason, Barbara J.
explores the physiological changes in the brain that drive excessive drinking and create vulnerability to relapse, and she investigates the viability of utilizing new compounds to modulate the neurological effects of alcohol, reduce excessive intake, and prevent relapse.
Miller, Courtney Anne
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Parsons, Loren H.
studies neurochemical mechanisms in drug dependence with the goal of characterizing neural pathologies that may be viable targets for a pharmacotherapy of addiction; particular focus is on the central serotonin and endocannabinoid systems.
Roberto, Marisa
uses in vitro electrophysiological techniques to understand the effects of abused drugs and neuropeptides on neuronal function and synaptic transmission.
Roberts, Amanda J.
investigates the neural bases of motivated behaviors such as drug self-administration, exploratory drive, and feeding.
Sanna, Pietro P.
is interested in the molecular bases of forms of neural plasticity associated with physiologic events, such as learning, and pathologic events, such as the development of substance dependence.
Schweitzer, Paul P.
focuses on the cellular and molecular mechanisms of action of substances of abuse and their interaction with endogenous transmitter systems in the brain.
Siggins, George R.
uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.
Taffe, Michael A.
investigates the behavioral and physiological impact of exposure to substituted amphetamine drugs of abuse such as 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy) and methamphetamine; he is also studying the cognitive risks posed by chronic alcohol drinking during adolescence.
Weiss, Friedbert
investigates the neurobiology of addictive disorders, focusing on understanding the brain neurocircuitry as well as the neurochemical and molecular mechanisms that mediate the addictive effects of drugs of abuse, contribute to the development of dependence, and convey vulnerability to relapse.
