Burris, Thomas P
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Conkright, Michael D.
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Feeney, Ann J.
studies the epigenetic and genetic mechanisms that control the accessibility of antibody V, D, and J genes to undergo V(D)J recombination, determining why individual V genes rearrange with very different frequencies, and determining how the generation of the antibody repertoire and B cell tolerance mechanisms are misregulated in murine models of autoimmune disease
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Hanneken, Anne M.
explores the ability of flavonoids to prevent oxidative stress and cell death in the retina, with the long-term goal of developing preventative therapies for people at high risk for macular degeneration and blindness.
Jameson, Julie Marie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Liang, Chris
Design, synthesis, and testing of novel small molecular therapeutics.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Salomon, Daniel R.
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Schmid, Sandra L.
is defining the molecular mechanisms of receptor-mediated endocytosis, which involves the concentration of receptor-ligand complexes into clathrin coated pits, their internalization via coated vesicles, and the regulation of these events by GTPases and kinases.
Sherman, Linda A.
looks at the immune system's basic strategy of discriminating between "self" and "non-self" through T lymphocytes, seeking to augment their ability to respond to certain self-antigens on tumor cells and to diminish their aberrant destruction of self-tissue in autoimmune diseases.
Surh, Charles D.
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
