Barbas III, Carlos F.
designs zinc finger protein-based transcription factors for the directed regulation of gene expression and gene discovery; programs complex reaction mechanisms into antibodies and uses them to treat cancer; develops new approaches to catalytic asymmetric synthesis; and uses phage display methods to evolve antibodies with the potential to become new immunotherapeutic and gene therapeutic approaches to diseases like breast and ovarian cancer, melanoma, and AIDS.
Bokoch, Gary M.
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Gale, Andrew
investigates Factor VIII and other proteins involved in blood coagulation with the hope of finding improved therapies for hemophilia A.
Havran, Wendy L.
studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.
Heeb, Mary J.
examines the biochemistry and mechanism of action of novel anticoagulant molecules like protein Z and protein S, which may be valuable targets for intervention in thrombotic and vascular diseases.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Petrie, Howard T.
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Quigley, James P.
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Ruggeri, Zaverio M.
investigates the mechanisms involved in normal and pathogenic platelet adhesion and the formation of blood clots.
Torbett, Bruce E.
studies transcriptional regulation of myeloid development and function, develops and tests novel techniques for delivering genes to cells to provide protection against HIV or cancer; he also investigates how the structural changes in HIV protease contribute to biochemical functions that confer protease inhibitor resistance.
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
