Baccala, Roberto
is studying mechanisms of T-cell homeostasis and associated defects in autoimmunity, focusing on developing new therapies for autoimmune diseases and cancer.
Beutler, Bruce
searches for genes that are required for normal immune function through germline mutagenesis and positional cloning.
Bokoch, Gary M.
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Burton, Dennis R.
focuses his research primarily on human antibody responses to HIV and the design of an HIV vaccine. He has also worked on the interaction of antibodies and other pathogens, including respiratory syncytial virus, Ebola virus and prion proteins.
Chisari, Francis V.
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Cochrane, Charles G.
is involved in studies of the biochemical pathways of injury in the inflammatory process, and has developed a synthetic peptide modeled after surfactant protein B, which is being used for the treatment of pre-term infants, adults with acute lung injury, and patients with acute asthma.
Curtiss, Linda K.
examines the role of innate immunity in atherosclerosis using bone marrow transplantation in models of atherosclerosis.
Dickerson, Tobin Jarret
develops biochemical technologies for predicting and treating evolving disease such as influenza, hepatitis C, and cancer, high-throughput screening paradigms for protein-ligand agonists/antagonists, combating filarial parasites, and the modulation of botulinum neurotoxin.
Feeney, Ann J.
studies the epigenetic and genetic mechanisms that control the accessibility of antibody V, D, and J genes to undergo V(D)J recombination, determining why individual V genes rearrange with very different frequencies, and determining how the generation of the antibody repertoire and B cell tolerance mechanisms are misregulated in murine models of autoimmune disease
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Gascoigne, Nicholas R.J.
examines molecular and genetic interactions in T cell development and activation, including the spatiotemporal analysis of signaling cascades using fluorescence resonance energy transfer (FRET) and other techniques to image molecular interactions in live cells.
Guidotti, Luca G.
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
Havran, Wendy L.
studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.
Hwang, Inkyu
investigates cellular mechanisms underlying T cell receptor-mediated integrin activation and develops cell-based high throughput assay systems useful for isolation of small molecules modulating T cell immune functions.
Jameson, Julie Marie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Janda, Kim D.
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Kono, Dwight H.
is investigating the pathogenesis of systemic lupus erythematosus and mercury-induced autoimmunity as well as seeking to identify new potential therapeutic targets through novel approaches; his main interest is to define both predisposing genes and genes critical for disease development.
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
McHeyzer-Williams, Michael George
studies the cellular and molecular regulation of antigen-specific immune memory in vivo with emphasis on the innate/adaptive interface and helper T cell regulated B cell responses to optimize vaccines.
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Mosier, Donald E.
studies the the basic biology of human immunodeficiency virus (HIV) and its viral dynamics in vivo, looking at how the replication and infectivity of the virus alters with mutations to its genome.
Mowen, Kerri A.
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Nemerow, Glen R.
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Oldstone, Michael B.
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Ollmann Saphire, Erica Ollmann
combines x-ray crystallography, biochemistry, and immunology to analyse proteins that play key roles in the pathogenesis of Ebola and other viral hemorrhagic fevers; structures of these proteins provide templates for vaccine design and enable rapid responses to newly emerging forms of the viruses.
Paulson, James C.
studies carbohydrate recognition and the molecular biology of carbohydrate binding proteins, like CD22, which mediate key aspects of cell signaling in the immune system.
Petrie, Howard T.
focuses on the production of specialized blood cells called T lymphocytes, which are central mediators of the immune response. Understanding this is central in developing treatments for immunodeficiencies resulting from environmental exposure (such as HIV/AIDS) or aging.
Pollard, Kenneth M.
studies how interactions between the environment and genetics affect induction and severity of autoimmune diseases.
Quigley, James P.
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Salomon, Daniel R.
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Sherman, Linda A.
looks at the immune system's basic strategy of discriminating between "self" and "non-self" through T lymphocytes, seeking to augment their ability to respond to certain self-antigens on tumor cells and to diminish their aberrant destruction of self-tissue in autoimmune diseases.
Strosberg, Donny D.
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Surh, Charles D.
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.
Tan, Eng M.
seeks to identify the antibodies involved in autoimmune diseases like lupus and scleroderma, characterize their intracellular antigens, and investigate the relationship of the autoimmune response to disease mechanisms.
Theofilopoulos, Argyrios
works on the identification of predisposing and effector genes in systemic autoimmunity, as exemplified in spontaneous mouse models of lupus. Both forward (phenotype → genes) and reverse (gene → phenotype) approaches are used and several genes that promote (type I and II IFNs) or suppress (coronin 1A) this disease have thus far been identified.
Whitton, J. Lindsay L.
studies antiviral immunity mediated by the recognition of viral peptides by host cells, the basis of immunization with plasmid DNA vaccines, and the role of the immune system in viral pathogenesis during coxsackievirus infections.
Wilson, Ian A.
has broad structural biology and structural genomics programs to determine thee-dimensional structure and biological function in a number of systems related to humoral, cellular and innate immunity, human disease, drug and vaccine design, influenza virus, HIV-1 , the expanding protein universe and metagenomics.
Xiao, Changchun
studies the functions of microRNA control and its underlying molecular mechanisms in the mammalian immune system, under health and disease conditions.
