Asahara, Hiroshi
is a molecular biologist and orthopedic surgeon who examines the precise mechanism of chromatin-dependent gene regulation, combining new findings in molecular and developmental biology with clinical research in the field of locomotive science to develop innovative new therapies for patients with arthritis, bone tumor and spinal cord injuries.
Baccala, Roberto
is studying mechanisms of T-cell homeostasis and associated defects in autoimmunity, focusing on developing new therapies for autoimmune diseases and cancer.
Baran, Phil S.
explores new avenues for the efficient and practical construction of organic molecules, both naturally occurring and man-made, by pursuing longstanding synthetic challenges and by designing methods of broad utility.
Bokoch, Gary M.
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Buxbaum, Joel N.
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Hwang, Inkyu
investigates cellular mechanisms underlying T cell receptor-mediated integrin activation and develops cell-based high throughput assay systems useful for isolation of small molecules modulating T cell immune functions.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Liang, Chris
Design, synthesis, and testing of novel small molecular therapeutics.
Mowen, Kerri A.
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Nicolaou, K.C.
works on the total synthesis of biologically active natural and designed molecules and the discovery and development of new synthetic strategies and technologies.
Pollard, Kenneth M.
studies how interactions between the environment and genetics affect induction and severity of autoimmune diseases.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Surh, Charles D.
studies how naive and memory T cells develop and survive under normal physiological conditions, and explores new ways of modulating T cells populations for treatment of cancer and autoimmune diseases.
Tan, Eng M.
seeks to identify the antibodies involved in autoimmune diseases like lupus and scleroderma, characterize their intracellular antigens, and investigate the relationship of the autoimmune response to disease mechanisms.
Theofilopoulos, Argyrios
works on the identification of predisposing and effector genes in systemic autoimmunity, as exemplified in spontaneous mouse models of lupus. Both forward (phenotype → genes) and reverse (gene → phenotype) approaches are used and several genes that promote (type I and II IFNs) or suppress (coronin 1A) this disease have thus far been identified.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
