Burton, Dennis R.
focuses his research primarily on human antibody responses to HIV and the design of an HIV vaccine. He has also worked on the interaction of antibodies and other pathogens, including respiratory syncytial virus, Ebola virus and prion proteins.
Chisari, Francis V.
studies the immunological basis for viral clearance and disease pathogenesis during persistent viral infections, especially HBV and HCV, the ability of T cell-derived cytokines to inhibit viral replication without killing infected cells, the signaling pathways and effector molecules that mediate these antiviral effects, and the viral evasion strategies that subvert them.
Dawson, Philip Edward
develops novel chemical ligation methodologies for the synthesis of natural and chemically engineered proteins to develop novel peptide based vaccines for HIV-1, study the molecular basis of protein folding and enzymatic catalysis, conjugate biological macromolecules to in complex systems such as cells, viruses and Quantum Dots and to develop synthetic protein pharmaceuticals.
Elder, John H.
focuses on the molecular and biological characterization of feline immunodeficiency virus (FIV), which causes an AIDS-like disease in the domestic cat and is similar to human immunodeficiency virus (HIV); his goal is to develop drug treatments and vaccines that may be employed to treat viral infections in both humans and cats.
Finn, M.G.
uses viruses as building blocks for biologically active structures, diagnostic agents, immunogenic platforms, and drug delivery vehicles; and also develops new bioconjugation methods, enzyme inhibitors, and functional materials using "click chemistry," and studies organic and organometallic reaction mechanisms.
Gallay, Philippe
looks at the glycoprotein attachment receptors on human cells that enhance the entry of HIV and works toward using those proteins as a guide for drug design.
Gerace, Larry
seeks to understand the mechanisms for regulation of signaling and cell differentiation by components of the nuclear envelope, particularly in regard to muscle, and the machinery for posttranscriptional regulation of gene expression by nucleocytoplasmic transport, mRNA translation and protein turnover, with focus on HIV-1.
Johnson Jr., John Emil
uses a variety of cellular and molecular biology methods to develop and test atomic resolution models of particle-related events in the virus life cycle; he also uses viruses as a paradigm for developing methods to determine atomic resolution models of cellular mega-structures.
Nemerow, Glen R.
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Ollmann Saphire, Erica Ollmann
combines x-ray crystallography, biochemistry, and immunology to analyse proteins that play key roles in the pathogenesis of Ebola and other viral hemorrhagic fevers; structures of these proteins provide templates for vaccine design and enable rapid responses to newly emerging forms of the viruses.
Salomon, Daniel R.
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Siuzdak, Gary E.
is interested in the design and application of mass spectrometry technology including pulsed laser desorption/ionization from silicon surfaces, understanding virus structure/activity, and metabolite profiling.
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
