Ayad, Nagi G.
studies the cell biological basis of cell cycle exit and differentiation of neuronal precursors as it relates to cancer and nerve regeneration.
Boger, Dale L.
works on the total synthesis of biologically active natural products using the tools of organic synthesis to identify, imitate, understand, exploit, and sometimes surpass what nature provides.
Bohn, Laura Michelle
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Bokoch, Gary M.
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Burris, Thomas P
research focuses on chemical biology of nuclear receptors, protein molecules that mediate hormone activity inside the cell that are potential drug targets for a number of diseases including prostate, breast and colon cancers, as well as type 2 diabetes, atherosclerosis, metabolic syndrome and autoimmunity.
Chun, Jerold Jun Ming
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Conkright, Michael D.
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Crossin, Kathryn Lynn
focuses on understanding the signaling capabilities of various cell adhesion molecules on the cell's plasma membrane, particularly the neural cell adhesion molecule, N-CAM, and its ability to signal hippocampal neural precursor cells to become neurons rather that astroglia and to activate the transcription factor NFkB in astrocytes.
Deniz, Ashok
develops and uses single-molecule fluorescence methods to study the dynamics and interactions of biological molecules during such processes as protein/RNA folding and assembly of the 30S subunit of the bacterial ribosome.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gascoigne, Nicholas R.J.
examines molecular and genetic interactions in T cell development and activation, including the spatiotemporal analysis of signaling cascades using fluorescence resonance energy transfer (FRET) and other techniques to image molecular interactions in live cells.
Gruol, Donna L.
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Hedlund, Peter B.
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Hoch, James A.
investigates developmentally programmed gene expression and signal transduction in cellular differentiation.
Izard, Tina
studies the structural dynamics of signaling mediators of adhesion junctions.
Jameson, Julie Marie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Lee, Jiing-Dwan
applies conditional knockout models to understand the mechanisms of action of the intracellular signaling pathways that are critical for the progression of tumors in humans in order to find molecular targets for cancer prevention and intervention.
Liang, Chris
Design, synthesis, and testing of novel small molecular therapeutics.
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
Mc Gowan, Clare H.
examines the molecular mechanisms and players that regulate the human cell cycle, focusing on DNA damage checkpoints and DNA repair enzymes like Mus81, which resolves strands of duplex DNA that become crossed during replication.
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Miller, Courtney Anne
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Mowen, Kerri A.
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Otomo, Takanori
studies structure and function of proteins involved in the autophagic pathway.
Reed, Steven I.
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Roberto, Marisa
uses in vitro electrophysiological techniques to understand the effects of abused drugs and neuropeptides on neuronal function and synaptic transmission.
Ruggeri, Zaverio M.
investigates the mechanisms involved in normal and pathogenic platelet adhesion and the formation of blood clots.
Russell, Paul R.
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.
Saez, Enrique
is interested in two broad themes related to the regulation of energy balance in mammals.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Schweitzer, Paul P.
focuses on the cellular and molecular mechanisms of action of substances of abuse and their interaction with endogenous transmitter systems in the brain.
Siggins, George R.
uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Strosberg, Donny D.
by studying protein-protein interactions in HCV, identifies and characterizes peptides and small molecules that affect host-pathogen relations, e.g. inhibit HCV release from cultured hepatoma cells.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Szurmant, Hendrik
is interested in the molecular mechanisms that govern signal
detection and signal transduction in Gram-positive bacteria
applying a combination of computational, structural, biochemical
and genetic approaches.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
Yang, Xiang-Lei
is elucidating the functional diversity of mammalian aminoacyl-tRNA synthetases in signal transduction pathways involving angiogenesis, neurogenesis, inflammation and apoptosis, and how the different functions of aminoacyl-tRNA synthetases are activated and regulated.
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
