Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Bohn, Laura Michelle
research is aimed at understanding how the molecular regulation of G protein coupled receptors (GPCR) can translate to overall therapeutic responsiveness in patients.
Chun, Jerold Jun Ming
is interested in the study of lysophospholipid signaling in neural and systems biology, chromosomal aneuploidy in the nervous system, and disease related studies with a Cellular and Molecular Neuroscience approach.
Cook, Boaz Shay
studies sensory processing of mechanical stimuli, from signal transduction in receptor cells to central neuronal networks; using the Drosophila model system to identify mechanosensory genes, study their role and analyze circuitry.
Cravatt, Benjamin F.
studies the action and regulation of chemical messengers, particularly the fatty acid amides, which mediate physiological phenomena like pain sensation, sleep, and thermoregulation; he designs and uses chemical probes for "active site proteomics," the global analysis of protein function.
Cunningham, Bruce Arthur
studies the detailed properties of cell surface glycoproteins that play critical roles in neural development, particularly cell adhesion molecules (CAMs), which bind cells together and generate signals that determine a cell's developmental destiny.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Gruol, Donna L.
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Hedlund, Peter B.
works on identifying and characterizing new molecular targets for the
treatment of neuropsychiatric disorders, especially depression.
Jegla, Timothy J.
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Kenny, Paul John
employs a multidisciplinary approach to investigate the underlying neurobiology of psychiatric disorders.
Koob, George F.
Investigates the neurobiological basis of emotional behavior focused on the theoretical constructs of reward and stress. His work explores the neural bases of motivation, reinforcement, behavioral responses to stress, and addiction.
Mandyam, Chitra Dhati
studies the neurogenic mechanisms altered by complex behavior patterns, including addiction, stress, depression and psychoses with emphasis on understanding the dynamics and mature cell fate of medial prefrontal cortex and hippocampal progenitors that partly maintain the adult medial prefrontal cortex and hippocampal plasticity.
Mason, Barbara J.
explores the physiological changes in the brain that drive excessive drinking and create vulnerability to relapse, and she investigates the viability of utilizing new compounds to modulate the neurological effects of alcohol, reduce excessive intake, and prevent relapse.
Miller, Courtney Anne
is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.
Milner, Richard Richard
uses a combination of mouse models and tissue culture cell–based assays to examine the role of fibronectin and endothelial fibronectin receptors in promoting cerebral angiogenesis during cerebral hypoxia and ischemia.
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Parsons, Loren H.
studies neurochemical mechanisms in drug dependence with the goal of characterizing neural pathologies that may be viable targets for a pharmacotherapy of addiction; particular focus is on the central serotonin and endocannabinoid systems.
Patapoutian, Ardem S.
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Roberto, Marisa
uses in vitro electrophysiological techniques to understand the effects of abused drugs and neuropeptides on neuronal function and synaptic transmission.
Schork, Nicholas J
focuses on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design, integration, and interpretation of studies making use of contemporary high throughput genomic technologies.
Schweitzer, Paul P.
focuses on the cellular and molecular mechanisms of action of substances of abuse and their interaction with endogenous transmitter systems in the brain.
Siggins, George R.
uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.
Sipe, Jack C.
is currently involved in molecular and experimental studies of endocannabinoid system genetic risk factors for drug abuse, autoimmune disorders and neurological disorders with a specialty in multiple sclerosis.
Stevens, Raymond C.
uses crystallography and biochemistry to probe the structure and function of molecules involved in neurotransmission and neurochemistry, seeking to understand how neuronal cells communicate at the molecular level and to create new molecules that affect neuronal signal transduction and recognition.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Taffe, Michael A.
investigates the behavioral and physiological impact of exposure to substituted amphetamine drugs of abuse such as 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy) and methamphetamine; he is also studying the cognitive risks posed by chronic alcohol drinking during adolescence.
Thomas, Elizabeth Anne
investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.
Weiss, Friedbert
investigates the neurobiology of addictive disorders, focusing on understanding the brain neurocircuitry as well as the neurochemical and molecular mechanisms that mediate the addictive effects of drugs of abuse, contribute to the development of dependence, and convey vulnerability to relapse.
