Baccala, Roberto
is studying mechanisms of T-cell homeostasis and associated defects in autoimmunity, focusing on developing new therapies for autoimmune diseases and cancer.
Bartfai, Tamas
directs the Harold L. Dorris Neurological Research Center, which investigates neurological disorders, including schizophrenia and Alzheimer's disease, and which seeks to advance knowledge of the process of aging of the brain.
Beutler, Bruce
searches for genes that are required for normal immune function through germline mutagenesis and positional cloning.
Bokoch, Gary M.
studies the control and integration of cellular activities initiated by GTP-binding proteins, seeking to determine how GTP-binding proteins function, how they are regulated at the molecular level, and how this regulation may be abnormal in various disease states.
Cochrane, Charles G.
is involved in studies of the biochemical pathways of injury in the inflammatory process, and has developed a synthetic peptide modeled after surfactant protein B, which is being used for the treatment of pre-term infants, adults with acute lung injury, and patients with acute asthma.
Curtiss, Linda K.
examines the role of innate immunity in atherosclerosis using bone marrow transplantation in models of atherosclerosis.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gruol, Donna L.
examines the pathways and mechanisms involved in neuronal signaling in the mammalian central nervous system (CNS), developmental expression of signaling pathways, and the neuroadaptive mechanisms through which CNS disease and drugs alter neuronal signaling and viability.
Guidotti, Luca G.
studies the pathogenetic mechanisms involved in liver disease with the aim of developing new approaches for the treatment of chronic viral hepatitis.
Havran, Wendy L.
studies a unique subset of T lymphocytes, called "gamma-delta" T cells, which reside in epithelial tissues, are derived from fetal precursors, express a tissue-specific, invariant antigen receptor, and are involved in tissue repair as well as epithelial inflammatory diseases such as asthma and ulcerative colitis.
Jameson, Julie Marie
is examining the mechanisms involved in the dysregulation of skin γδ T cells in nonhealing wounds.
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
McKay, Dianne
explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.
Mowen, Kerri A.
investigates the molecular events which control T helper cell and mast cell function, specifically studying a role for the posttranslational modification of arginine methylation by isolating novel substrates, determining the effects of arginine methylation on substrate function, and creating mice deficient in the enzymes that regulate arginine methylation.
Nemerow, Glen R.
investigates the interaction of adenovirus with host cells, looking at the basic mechanisms involved in virus attachment, internalization, membrane penetration, and nuclear localization, and seeking to design novel adenoviral vectors with increased capacity to deliver therapeutic genes to specific cell types.
Oldstone, Michael B.
studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.
Phinney, Donald G
employs a multi-disciplinary approach to study the basic biology of mesenchymal stem cells and their potential as vectors to treat inflammatory and neurodegenerative disorders.
Pollard, Kenneth M.
studies how interactions between the environment and genetics affect induction and severity of autoimmune diseases.
Quigley, James P.
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Sipe, Jack C.
is currently involved in molecular and experimental studies of endocannabinoid system genetic risk factors for drug abuse, autoimmune disorders and neurological disorders with a specialty in multiple sclerosis.
Theofilopoulos, Argyrios
works on the identification of predisposing and effector genes in systemic autoimmunity, as exemplified in spontaneous mouse models of lupus. Both forward (phenotype → genes) and reverse (gene → phenotype) approaches are used and several genes that promote (type I and II IFNs) or suppress (coronin 1A) this disease have thus far been identified.
Torbett, Bruce E.
studies transcriptional regulation of myeloid development and function, develops and tests novel techniques for delivering genes to cells to provide protection against HIV or cancer; he also investigates how the structural changes in HIV protease contribute to biochemical functions that confer protease inhibitor resistance.
Whitton, J. Lindsay L.
studies antiviral immunity mediated by the recognition of viral peptides by host cells, the basis of immunization with plasmid DNA vaccines, and the role of the immune system in viral pathogenesis during coxsackievirus infections.
