Baldwin, Kristin K.
studies the sense of smell by genetically visualizing the neural circuits of the mouse olfactory system and uses mouse cloning and stem cell technology to investigate the molecular mechanisms that govern neural circuit formation and function throughout the nervous system.
Beutler, Bruce
searches for genes that are required for normal immune function through germline mutagenesis and positional cloning.
Bois, Philippe Roger Jean
works to determine the mechanisms that define and control recombinogenic regions in complex mammalian genomes.
Buxbaum, Joel N.
utilizes genetic epidemiology, transgenic animals, cell culture, and molecular biologic techniques to study the etiology and pathogenesis of age-related human diseases of protein conformation.
Conkright, Michael D.
studies the molecular events that govern the conversion of the cyclic AMP signaling cascade into transcriptional activation of target gene using cell-based high-throughput technologies.
Cook, Boaz Shay
studies sensory processing of mechanical stimuli, from signal transduction in receptor cells to central neuronal networks; using the Drosophila model system to identify mechanosensory genes, study their role and analyze circuitry.
Feeney, Ann J.
studies the epigenetic and genetic mechanisms that control the accessibility of antibody V, D, and J genes to undergo V(D)J recombination, determining why individual V genes rearrange with very different frequencies, and determining how the generation of the antibody repertoire and B cell tolerance mechanisms are misregulated in murine models of autoimmune disease
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Franc, Nathalie C
studies phagocytosis, the process by which dying cells are recognized and cleared during embryogenesis in the fruit fly, Drosophila melanogaster. Her long-term goal is to compare its molecular mechanisms with that of phagocytosis of pathogens, such as bacteria.
Hoch, James A.
investigates developmentally programmed gene expression and signal transduction in cellular differentiation.
Jegla, Timothy J.
aims to define the molecular pathways through which potassium channels regulate neuronal signaling.
Kishi, Shuji
aims to develop a high-throughput processing system for gene identification and phenotype characterization particularly associated with age-related disorders in humans, using zebarfish as an amenable vertebrate model system.
Kono, Dwight H.
is investigating the pathogenesis of systemic lupus erythematosus and mercury-induced autoimmunity as well as seeking to identify new potential therapeutic targets through novel approaches; his main interest is to define both predisposing genes and genes critical for disease development.
Kralli, Anastasia
focuses on the mechanism of action of nuclear receptor coactivators that modulate transcriptional responses to small lipophilic hormones and confer specificity to hormone signaling.
Lazzerini Denchi, Eros
focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging
Lee, Jiing-Dwan
applies conditional knockout models to understand the mechanisms of action of the intracellular signaling pathways that are critical for the progression of tumors in humans in order to find molecular targets for cancer prevention and intervention.
Luo, Junli
focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis
Mueller, Ulrich
focuses on the genes and the gene mutations that contribute to the pathology of Usher syndrome, other human diseases related to mechanosensory perception, and central nervous system diseases
Nemazee, David
studies "receptor editing," a novel immunological tolerance mechanism in which developing B lymphocytes that carry autoreactive cell surface antibody are stimulated to "reprogram" their immunoglobulin genes by further rounds of DNA recombination.
Patapoutian, Ardem S.
studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.
Reed, Steven I.
focuses on the regulation of cell cycle progression through cyclin-dependent kinases and related proteins, particularly the role of regulated proteolysis in cell cycle control and how defects in the proteolytic machinery can promote carcinogenesis.
Roberts, Amanda J.
investigates the neural bases of motivated behaviors such as drug self-administration, exploratory drive, and feeding.
Russell, Paul R.
studies DNA damage response mechanisms that are relevant to the prevention and treatment of cancer; investigates how cells tolerate exposure to environmental toxins.
Sauer, Karsten
We combine broad functional genomics approaches with traditional, hypothesis-driven research to identify and functionally characterize novel genes with important roles in lymphocyte development and function. A particular focus of the lab are signal transduction mechanisms downstream of the T cell receptor.
Schork, Nicholas J
focuses on the development and implementation of analysis methods for understanding the genetic determinants of complex human traits and diseases such as cancer, neuropsychiatric disease, and cardiovascular disease. These methods focus on both the design, integration, and interpretation of studies making use of contemporary high throughput genomic technologies.
Sipe, Jack C.
is currently involved in molecular and experimental studies of endocannabinoid system genetic risk factors for drug abuse, autoimmune disorders and neurological disorders with a specialty in multiple sclerosis.
Stowers, Lisa
studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.
Sun, Peiqing
seeks to delineate the signal transduction pathways mediating cellular responses to oncogenic mutations, and to systematically search for genetic alterations that contribute to specific cancer-associated phenotypes by screening cDNA expression libraries and siRNA libraries.
Szurmant, Hendrik
is interested in the molecular mechanisms that govern signal
detection and signal transduction in Gram-positive bacteria
applying a combination of computational, structural, biochemical
and genetic approaches.
Tellinghuisen, Timothy Lee
focuses on understanding the assembly, composition, and activities of the RNA replication machinery of the hepatitis c virus
Theofilopoulos, Argyrios
works on the identification of predisposing and effector genes in systemic autoimmunity, as exemplified in spontaneous mouse models of lupus. Both forward (phenotype → genes) and reverse (gene → phenotype) approaches are used and several genes that promote (type I and II IFNs) or suppress (coronin 1A) this disease have thus far been identified.
Topol, Eric
studies the genome of patients who have particular medical conditions or who have been healthy beyond the 8th decade to determine variants associated with the phenotype. His research moves this information forward in medicine to provide individualization of medical care in the future.
Winzeler, Elizabeth A.
develops new genome analysis technologies and applies them to study agents of infectious disease, such as the malaria parasite Plasmodium falciparum; her goal is to use genome sequence information, microarrays, and proteomics as a substitute for traditional forward and reverse genetic approaches for elucidation of gene function.
Wittenberg, Curt
studies the role of cell cycle regulated transcription and proteolysis in cell cycle regulation via cyclin dependent protein kinases.
Xiao, Changchun
studies the functions of microRNA control and its underlying molecular mechanisms in the mammalian immune system, under health and disease conditions.
