Baran, Phil S.
explores new avenues for the efficient and practical construction of organic molecules, both naturally occurring and man-made, by pursuing longstanding synthetic challenges and by designing methods of broad utility.
Barbas III, Carlos F.
designs zinc finger protein-based transcription factors for the directed regulation of gene expression and gene discovery; programs complex reaction mechanisms into antibodies and uses them to treat cancer; develops new approaches to catalytic asymmetric synthesis; and uses phage display methods to evolve antibodies with the potential to become new immunotherapeutic and gene therapeutic approaches to diseases like breast and ovarian cancer, melanoma, and AIDS.
Boger, Dale L.
works on the total synthesis of biologically active natural products using the tools of organic synthesis to identify, imitate, understand, exploit, and sometimes surpass what nature provides.
Dawson, Philip Edward
develops novel chemical ligation methodologies for the synthesis of natural and chemically engineered proteins to develop novel peptide based vaccines for HIV-1, study the molecular basis of protein folding and enzymatic catalysis, conjugate biological macromolecules to in complex systems such as cells, viruses and Quantum Dots and to develop synthetic protein pharmaceuticals.
Ding, Sheng
is applying arrayed large-scale chemical, cDNA, and siRNA libraries and novel high throughput cellular screens to identify and characterize small molecules and genes that can control stem cell fate in various embryonic and adult stem cell systems and modulate specific signaling pathways in development and regeneration.
Feng, Yangbo
focuses on the lead identification and optimization of drug candidates.
Finn, M.G.
uses viruses as building blocks for biologically active structures, diagnostic agents, immunogenic platforms, and drug delivery vehicles; and also develops new bioconjugation methods, enzyme inhibitors, and functional materials using "click chemistry," and studies organic and organometallic reaction mechanisms.
Fokin, Valery
develops preactical catalytic transformations for organic synthesis, combinatorial chemistry, chemical biology, and materials research; searches for novel antiviral agents, nicotinic receptor ligands, and protease inhibitors.
Janda, Kim D.
Investigates biological catalysts, development of methods for the detection of and protection against chemical/biological warfare agents, combinatorial chemical libraries, synthesis and evaluation of enzyme inhibitors, solid-phase organic synthesis, quorum sensing within bacterial systems, lead discovery and detection strategies for tropical diseases, antibody/peptide phage display libraries, cell-penetrating peptides as therapeutic delivery vehicles, and the application of immunopharmacotherapy in the treatment of drug addiction, cancer and obesity.
Keinan, Ehud
Kelly, Jeffery William
examines the bioorganic and biophysical chemistry of aberrant conformational changes in proteins associated with misfolding diseases, seeking to develop new approaches for preventing these diseases with purposefully designed small molecules.
Liang, Chris
Design, synthesis, and testing of novel small molecular therapeutics.
Micalizio, Glenn Christophe
focuses research on the development of new chemical methods and strategies for the total synthesis of complex biologically interesting natural products, and for the discovery of small molecules with interesting biological properties.
Nicolaou, K.C.
works on the total synthesis of biologically active natural and designed molecules and the discovery and development of new synthetic strategies and technologies.
Periana, Roy A
focuses on the design, discovery and study of new coordination catalysts for the selective reaction of strong bonds with the goal of developing new Energy and Material chemistries that is cleaner, lower cost and allows the use of alternative feed stocks.
Rebek Jr., Julius
studies basic questions of molecular recognition, self-assembly, catalysis, and complementarity by designing novel organic molecular nanocapsules and synthetic receptors.
Roush, William R.
focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.
Sharpless, K. Barry
discovers new and useful transformations for organic synthesis, particularly employing inorganic catalysts and olefin-derived compounds of high reactivity; he also applies "in situ" click chemistry, which makes enzymes into reaction vessels and templates for the formation of their own inhibitors.
Wong, Chi-Huey
directs his research towards the development of new chemical-enzymatic strategies for the synthesis of biologically active compounds and chiral intermediates; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Yu, Jin-Quan
Discovers regioselective and enantioselective reactions based on C-H activations and applies these reactions to drug discovery and natural product synthesis.
