Curtiss, Linda K.
examines the role of innate immunity in atherosclerosis using bone marrow transplantation in models of atherosclerosis.
Felding-Habermann, Brunhilde
establishes unique models of brain metastasis from circulating tumor cells of breast cancer patients and analyzes their properties in vitro and in vivo, investigates genes and functional pathways that control metastatic activity.
Fowler, Velia
studies the role of actin dynamics in regulating assembly and function of cytoskeletal structures that contribute to cell and tissue morphogenesis during embryonic development. Systems of interest include morphogenesis of epithelia, the eye lens, differentiation and stability of erythrocytes, and striated muscle development.
Friedlander, Martin
examines the mechanisms whereby proteins are asymmetrically integrated into cell membranes and studies the basic mechanisms of ocular angiogenesis and potential therapeutic applications for treating degenerative retinal and neovascular eye diseases.
Gale, Andrew
investigates Factor VIII and other proteins involved in blood coagulation with the hope of finding improved therapies for hemophilia A.
Heeb, Mary J.
examines the biochemistry and mechanism of action of novel anticoagulant molecules like protein Z and protein S, which may be valuable targets for intervention in thrombotic and vascular diseases.
Milner, Richard Richard
uses a combination of mouse models and tissue culture cell–based assays to examine the role of fibronectin and endothelial fibronectin receptors in promoting cerebral angiogenesis during cerebral hypoxia and ischemia.
Quigley, James P.
uses in vivo models, directed enzyme inhibitors and specific function-blocking antibodies to identify pathways and molecules which contribute to tumor metastasis and angiogenesis.
Riewald, Matthias
studies signaling of protease-activated receptor 1 and activated protein C in blood coagulation and systemic inflammation.
Ruggeri, Zaverio M.
investigates the mechanisms involved in normal and pathogenic platelet adhesion and the formation of blood clots.
Salomon, Daniel R.
investigates how molecular mechanisms driving immune cell activation and tissue injury, both critical components of cell and organ transplant rejection, are regulated at the gene transcriptional and proteomic level to map molecular networks that determine clinical outcomes.
Yeager, Mark J.
uses high resolution electron cryo-microscopy and image analysis to explore the architecture of supramolecular assemblies, such as transmembrane signaling proteins and channels (integrins, gap junction channels, and aquaporins) and viruses responsible for significant human disease (rotaviruses, astroviruses, and retroviruses).
