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Harold L. Dorris
Neurological Research Institute


Publications

 

  1. Bajo, M., Roberto, M., Schweitzer, P. (2009) Alteration of Hippocampal Synaptic Transmission and Potentiation by Cannabinoid Ligands. J Neurosci Res15, 766-775.
  2. Cottone, P., Sabino, V., Steardo, L., Zorrilla, E.P. (2009) Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinology 34:38-49,2009).
  3. Emonet, S.F., Garidou, L., McGavern, D., and de la Torre, J.C.(2009) The arenavirus Swiss knife: generation of recombinant lymphocytic choriomeningitis viruses (LCMV) with tri-segmented genomes stably expressing two additional genes of interest (in press PNAS).
  4. Kang-Park, M., Kieffer, B.L., Roberts, A.J., Roberto, M., Madamba, S.G., Siggins, G.R., Moore, S.D. (2009) Mu opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. J Pharmacol Exp Ther. 328, 284-293.
  5. Kenny, P.J., Chartoff, E., Roberto, M., Carlezon, W.A. Jr., Markou A. (2009) NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central amygdala. Neuropsychopharmacology 34, 266-281.
  6. Kim, J.V., Kang, S.S., Dustin, M.L. McGavern, D.B. (2009) Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 457, 191-195.
  7. Marsolais, D., Hahm, B., Walsh, K., Edelman, K.H., McGavern, D., Hatta, Y., Kawaoka, Y., Rosen, H., Oldstone, M.B. (2009) A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc. Natl. Acad. Sci. USA 106, 1560-1565.
  8. Nie, Z., Zorrilla, E.P., Madamba, S.G., Roberto, M., and Siggins G.R. (2009) Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. Scientific World Journal 9, 68-85.
  9. Spulber, S., Mateos, L., Oprica, M., Cedazo-Minguez, A., Bartfai, T., Winblad, B., and Schultzberg, M. (2009) Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J. Neuroimmunol 10.1016/j.jneurim. (2009).01.010.
  10. Truong, P., McGavern, D.B. (2009) Persistent viral infection elevates CNS MHC I through chronic production of interferons (in press J Immunol).
  11. Balosso, S., Maroso, M., Sanchez-Alavez, M., Ravizza, T., Frasca, A., Bartfai, T., Vezzani, A. (2008) A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin- 1β . Brain Oct 24. [Epub ahead of print].
  12. Cottone, P., Sabino, V., Steardo, L., Zorrilla, E.P. (2008) Opioid-Dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology 33, 524-535.
  13. Cottone, P., Sabino, V., Steardo, L., Zorrilla, E.P. (2008) Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats. Am J Physiol Regul Integr Comp Physiol 295, R1066-R1076.
  14. Cruz, M.T., Bajo, M., Schweitzer, P., Roberto M. (2008) Shared mechanisms of alcohol and other drugs. Alcohol Research and Health, Vol. 31, No. 2.
  15. Greenwell, T.N., Walker, B.M., Cottone, P., Zorrilla, E.P., Koob, G.F. (2008) The α1 Adrenergic Receptor Antagonist Prazosin Reduces Heroin Self-Administration in Rats with Extended Access to Heroin Administration. Pharmacology, Biochemistry and Behavior 10.1016/j.pbb.2008.07.012.
  16. Mayorov, A.V., Amara, N.,Chang, J.Y., Moss, J.A., Hixon, M.S., Ruiz, D.I., Meijler, M.M., Zorrilla, E.P., Janda, K.D. (2008) Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice. Proc. Natl. Acad. Sci. USA 105, 17487-17492.
  17. Osborn, O., Brownell, S.E., Sanchez-Alavez, M., Salomon, D., Gram, H., Bartfai, T. (2008) Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine 44, 141-148.
  18. Sabino, V., Cottone, P., Zhao, Y., Iyer, M.R., Steardo, L. Jr., Steardo, L., Rice, K.C., Conti, B., Koob, G.F., Zorrilla, E.P. (2008) The sigma-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking. Neuropsychopharmacology (22 Oct 2008) doi:10/1038/npp.2008.192.
  19. Sabino, V., Cottone, P., Parylak, S.L., Steardo, L., Zorrilla, E.P. (2008) Sigma-1 receptor knockout mice display a depressive-like phenotype. Behavioural Brain Research 10.1016/j.bbr.2008.11.036.
  20. Sanchez-Alavez, M., Criado, J.R., Klein, I., Moroncini, G., Conti, B. (2008) Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice. Neuroreport 19, 1473-1477.
  21. Trifilo, M.J., Sanchez-Alavez, M., Solforosi, L., Bernard-Trifilo, J., McGavern, D.B., Oldstone, M.B.A. (2008) Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the GABAergic pathway. J Virol. 82, 9890-9899.
  22. Bartfai, T., Insel, T., Fishell,G., Rothwell, N. (2008) Choices in neuroscience careers. Nat. Rev. Neurosci. 9, 401-405.
  23. Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., Bartfai, T. Cytokine receptors in the brain. (2008) In: NeuroImmune Biology. Vol. 6: Cytokines and the Brain (C. Phelps and E. Korneva eds.) Amsterdam, The Netherlands 21-38.
  24. Mitsukawa, K., Lu, X., Bartfai, T. (2008) Galanin, galanin receptors and drug targets. Cell. Mol. Life Sci. 65, 1796-1806.
  25. Osborn, O., Gram, H., Zorrilla, E.P., Conti, B., Bartfai, T. (2008) Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly. 138, 665-673.
  26. Bartfai, T., Lees, G. (2008) Drug Discovery, text book, Japanese edition.
  27. Bartfai, T., Insel, T., Fishell, G., Rothwell, N. (2008) Choices in neuroscience careers. Nat. Rev. Neurosci . 5, 401-405.
  28. Spulber, S., Oprica, M., Bartfai, T., Winblad, B., Schultzberg, M. (2008) Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur. J. Neurosci . 27, 549-558.
  29. Buxbaum, J.N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A.R., Bartfai, T. (2008) Transthyretin protects Alzheimer's mice from the behavioral and biochemical Effects of A β toxicity. Proc. Natl. Acad. Sci. U.S.A. 105, 2681-2686.
  30. Sharkey, L.M., Madamba, S.G., Siggins, G.R., Bartfai, T. (2008) Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus. Neurochem. Res. 33, 285-291.
  31. Sugama, S. and Conti, B. (2008) Interleukin 18 and stress. Review. Brain Research Reviews 58, 85-95.
  32. Conti, B. (2008) Considerations on Temperature, Longevity and Ageing. Cell Mol Life Sci. 65, 1626-1630, Review.
  33. Brooks, D.G., Lee, A., Elsaesser, H., McGavern, D.B., Oldstone, M.B.A. (2008) IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J. Exp. Med.205, 533-541.
  34. Kang, S.S., McGavern, D.B. (2008) Lymphocytic choriomeningitis infection of the central nervous system. Front. Biosci. 13, 4529-4543, Review.
  35. Truong, P., McGavern, D.B. (2008) A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of anti-viral memory cells. J Immunol. 181, 1161-1169.
  36. Roberto, M., Gilpin, N.W., O'Dell, L.E., Cruz, M.T., Morse, A.C., Siggins, G.R., Koob, G.F.(2008) Cellular and behavioral interactions of Gabapentin in treatment of alcohol dependence. J. Neurosci.
  37. Bajo, M., Cruz, M.T., Siggins, G.R., Messing, R., Roberto, M. (2008) Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala. Proc. Natl. Acad. Sci. U.S.A.105, 8410-8415.
  38. Lu, X., Ross, B., Sanchez-Alavez, M., Zorrilla, E.P., Bartfai, T. (2008) Phenotypic analysis of GalR2 knockout mice in anxiety and depression-related behavioral tests. Neuropeptides. 42, 387-397.
  39. Bartfai, T (2007) Target based drug discovery in the time of genomic medicine. SAPA Pharmaceutical & Biotechnology Conference, the 9th Shanghai International Forum on Biotechnology & Pharmaceutical Industry.
  40. Bartfai, T., Sanchez-Alavez, M., Andell-Jonsson, S., Schultzberg, M., Vezzani, A., Danielsson, E., Conti, B (2007) Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Ann. N.Y. Acad. Sci. 1113, 173-177.
  41. Lu, X., Sharkey, L., Bartfai, T (2007) The brain galanin receptors: targets for novel antidepressant drugs. CNS & neurological disorders drug targets 6, 183-192.
  42. Bartfai, T., Waalen, J., Buxbaum, J. N (2007) Adipose tissue as a modulator of clinical inflammation: does obesity reduce the prevalence of rheumatoid arthritis? J. Rheumatol . 34, 488-492.
  43. Sanchez-Alavez, M., Bartfai, T (2007) It all happens between Toll receptors and caspase 1. Proc. Natl. Acad. Sci. U.S.A. 104, 7733-7734.
  44. Lundström, L., Sollenberg, U.E., Bartfai, T., Langel, U (2007) Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions. J. Neurochem. 103, 1774-1784.
  45. Sotgiu, S., Sannella, A.R., Conti, B., Arru, G., Fois, M.L., Sanna, A., Severini, C., Morale, M.C., Marchetti, B., Rosati, G., Musumeci, S. (2007) Multiple sclerosis and anti-Plasmodium falciparum innate immune response. J. Neuroimmunol. 185, 201-207.
  46. Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., Bartfai, T (2007) Cytokine Receptors in the Brain. In Neuroimmune Biology, Volume 6; Cytokines in the Brain; I. Berczi and A. Szentivanyi Editors 21-38.
  47. Sugama, S., Fujita, M., Hashimoto, M., Conti, B (2007) Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. lNeuroscience 1388-1399.
  48. Sanchez-Alavez, M., Conti, B., Moroncini, G., Criado, J (2007) Contribution of neuronal prion protein on sleep recovery and stress response following sleep deprivation. Brain Research 1158, 71-80.
  49. Lauterbach, H., Truong, P., McGavern, D.B (2007) Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification. Virology J. 4, 53.
  50. Fekete, M., Inoue, K., Zhao, Y., Rivier, J.E., Vale, W.W., Szucs, A., Koob, G.F. Zorrilla, E.P. (2007) Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval, Neuropsychopharmacology 32, 1052-1068.
  51. Cottone, P., Sabino, V., Steardo, L., Zorrilla, E.P (2007) FG7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology 32, 1069-1081.
  52. Fekete, M. Zorrilla, E.P (2007) Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Frontiers in Neuroendocrinology 28, 1-27.
  53. Zorrilla, E.P., Brennan, M., Sabino, V., Lu, X., Bartfai, T (2007) Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiology & Behavio . 91, 479-485.
  54. Sabino, V., Cottone, P., Steardo, L., Schmidhammer, H., Zorrilla, E.P. (2007) 14-methoxymetopon, a highly potent μ opioid receptor agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology 192, 537-546.
  55. Zhao, Y., Weiss, F., Zorrilla, E.P. (2007) Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats. Alcoholism: Clin. Exper. Res. 31, 1505-1515.
  56. Cottone, P., Sabino, V., Nagy, T.R., Coscina, D.V., Zorrilla, E.P (2007) Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. J. Physiol. 583, 487-504.
  57. Zorrilla, E.P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B (2007) Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc. Natl. Acad. Sci. U.S.A. 104, 11097-11102.
  58. Zhao, Y., Valdez, G.R., Fekete, E.M., Rivier, J.E., Vale, W.W., Rice, K.C., Weiss, F., Zorrilla, E.P. (2007) Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats. J. Pharmacol. Exper. Therapeutics 323, 846-854.
  59. Richardson, H.N, Zhao, Y., Fekete, E.M., Funk, C.K., Wirsching, P., Janda, K.D., Zorrilla, E.P., Koob, G.F (2007) MPZP: A novel small molecule corticotrophin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology Biochemistry & Behavior. 88, 497-510.
  60. Sten Shi, T-J., Hua, X-Y., Lu, X., Malkmus, S., Kinney, J., Holmberg, K., Wirz, S., Ceccatelli, S., Yaksh, T., Bartfai, T., Hokfelt, T. (2006) Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur. J. Neurosci. 23, 627-636.
  61. Sollenberg, U.E., Lundstrom, L., Bartfai, T., Langel, U. (2006) M871-A novel peptide antagonist selectively recognizing the galanin receptor type 2. Int. J. Pep. Res. Ther. 12, 115-119.
  62. Robinson, J.K., Bartfai, T., Langel, U. (2006) Galanin/GALP receptors and CNS homeostatic processes. CNS Neurol. Disord. Drug Targets 5, 327-334.
  63. Bartfai, T. (2006) From lab bench to Wall Street. FASEB J. 10, 1578-1580.
  64. Kovacs, Z., Kekesi, K.A., Szilagyi, N., Abraham, I., Szekacs, D., Kiraly, N., Papp, E., Csaszar, I., Szego, E., Barabas, K., Peterfy, H., Erdei, A., Bartfai, T., Juhasz, G. (2006) Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats. Neuroscience 140, 731-742.
  65. Sugama S, Wang N, Shimokawa N, Koibuchi N, Fujita M, Hashimoto M, Dhabhar FS, Conti B. (2006) The adrenal gland is a source of stress-induced circulating IL-18. J. Neuroimmunol. 172, 59-65.
  66. Conti, B., Davis, C., Behrens, M.M., Rebeck, J., Bartfai, T. Toll-like receptors as pharmacological targets. (2006) In TLRs in inflammation. L.A.J. O'Neill & E. Brint Editors; Birkhauser Verlag, Basel, Boston, Berlin; pp 223-240.
  67. Wang, N., Sugama, S., Conti, B., Teramoto, A., Shibasaki, T.(2006) Interleukin-18 mRNA expression in the rat pituitary gland. J. Neuroimmunol. 173, 117-125.
  68. Roberto, M., Siggins, G. R. (2006) Nociceptin/Orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in the central amygdala. Proc. Natl. Acad. Sci. U.S.A. 103, 9715-9720.
  69. Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., and Conti, B (2007) Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency, Proceedings of the National Academy of Sciences of the United States of America 104, 11097-11102.
  70. Conti, B., Maier, R., Barr, A. M., Morale, M. C., Lu, X., Sanna, P. P., Bilbe, G., Hoyer, D. & Bartfai, T. (2007). Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Molecular psychiatry 12, 167-189.
  71. Fekete, E. M. & Zorrilla, E. P. (2007). Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient CRF paralogs. Frontiers in neuroendocrinology 28, 1-27.
  72. Funk, C. K., Zorrilla, E. P., Lee, M. J., Rice, K. C. & Koob, G. F. (2007). Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological psychiatry 61, 78-86.
  73. Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F. & Patapoutian, A. (2007). Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445, 541-545.
  74. O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P. & Koob, G. F. (2007). Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. The Journal of pharmacology and experimental therapeutics 320, 180-193.
  75. Sabino, V., Cottone, P., Steardo, L., Schmidhammer, H. & Zorrilla, E. P. (2007). 14-methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology 192, 537-546.
  76. Sanchez-Alavez, M., Klein, I., Brownell, S. E., Tabarean, I. V., Davis, C. N., Conti, B. & Bartfai, T (2007) Night eating and obesity in the EP3R-deficient mouse. Proceedings of the National Academy of Sciences of the United States of America 104, 3009-3014.
  77. Sanchez-Alavez, M., Chan, S. L., Mattson, M. P. & Criado, J. R. (2007). Electrophysiological and cerebrovascular effects of the alpha-secretase-derived form of amyloid precursor protein in young and middle-aged rats. Brain research 1131, 112-117.
  78. Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X. & Bartfai, T. (2007). Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiol Behav 91, 479-485.
  79. Cottone, P., Sabino, V., Steardo, L. & Zorrilla, E. P. (2007). FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology 32, 1069-1081.
  80. Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F. & Zorrilla, E. P. (2007). Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology 23, 1052-1068.
  81. Bandell, M., Dubin, A. E., Petrus, M. J., Orth, A., Mathur, J., Hwang, S. W. & Patapoutian, A. (2006). High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature neuroscience 9, 493-500.
  82. Barr, A. M., Kinney, J. W., Hill, M. N., Lu, X., Biros, S., Rebek, J., Jr. & Bartfai, T. (2006). A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neuroscience letters 405, 111-115.
  83. Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B. & Oldstone, M. B. (2006). Interleukin-10 determines viral clearance or persistence in vivo. Nature medicine 12, 1301-1309.
  84. Brooks, D. G., McGavern, D. B. & Oldstone, M. B. (2006) Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. The Journal of clinical investigation 116, 1675-1685.
  85. Chen, A., Zorrilla, E., Smith, S. & other authors (2006). Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci 26, 5500-5510.
  86. Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P. & Koob, G. F. (2006). Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology 31, 2692-2707.
  87. Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R. Morale, M.C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E.P., de Lecea, L., Bartfai, T. (2006) Transgenic mice with a reduced core body temperature have an increased life span. Science style='font-size:6.5pt; font-family:Verdana;color:black'> 314, 825-828.
  88. Davis, C. N., Mann, E., Behrens, M. M., Gaidarova, S., Rebek, M., Rebek, J., Jr. & Bartfai, T. (2006). MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proceedings of the National Academy of Sciences of the United States of America 103, 2953-2958.
  89. Davis, C. N., Tabarean, I., Gaidarova, S., Behrens, M. M. & Bartfai, T. (2006). IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. Journal of neurochemistry 98, 1379-1389.
  90. Dhaka, A., Viswanath, V. & Patapoutian, A. (2006). Trp ion channels and temperature sensation. Annu Rev Neurosci 29, 135-161.
  91. Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T. & Behrens, M. M. (2006). A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. J Neurosci 26, 1604-1615.
  92. Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. & de la Torre, J. C. (2006). Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. Journal of virology 80, 9082-9092.
  93. Lauterbach, H., Zuniga, E. I., Truong, P., Oldstone, M. B. & McGavern, D. B. (2006). Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. The Journal of experimental medicine 203, 1963-1975.
  94. Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A. & Story, G. M. (2006). More than cool: promiscuous relationships of menthol and other sensory compounds. Molecular and cellular neurosciences 32, 335-343.
  95. McGavern, D. B. (2006). Immunotherapeutic relief from persistent infections and amyloid disorders. Neurology 66, S59-64.
  96. Richardson, H. N., Zorrilla, E. P., Mandyam, C. D. & Rivier, C. L. (2006). Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology 147, 2506-2517.
  97. Roberto, M., Treistman, S. N., Pietrzykowski, A. Z. et al. (2006). Actions of acute and chronic ethanol on presynaptic terminals. Alcoholism, clinical and experimental research 30, 222-232.
  98. Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C. & Zorrilla, E. P. (2006). Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) 189, 175-186.
  99. Sanchez-Alavez, M., Tabarean, I. V., Behrens, M. M. & Bartfai, T. (2006). Ceramide mediates the rapid phase of febrile response to IL-1beta. Proceedings of the National Academy of Sciences of the United States of America 103, 2904-2908.
  100. Tabarean, I. V., Korn, H. & Bartfai, T. (2006). Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. Neuroscience 141, 1685-1695.
  101. Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L. & Oldstone, M. B. (2006). CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective. Virology 347, 234-245.
  102. Wirz, S. A., Tobias, P. S., Ulevitch, R. J., Aribibe, L. & Bartfai, T. (2006). TLR2 is required for the altered transcription of p75NGF receptors in gram positive infection. Neurochemical research 31, 297-301.
  103. Woodward, J. J., Ron, D., Winder, D. & Roberto, M. (2006). From blue states to up states: a regional view of NMDA-ethanol interactions. Alcoholism, clinical and experimental research 30, 359-367.
  104. Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M. & Janda, K. D. (2006). Vaccination against weight gain. Proceedings of the National Academy of Sciences of the United States of America 103, 13226-13231.
  105. Badie-Mahdavi, H., Behrens, M. M., Rebek, J. & Bartfai, T. (2005). Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39, 249-251.
  106. Badie-Mahdavi, H., Lu, X., Behrens, M. M. & Bartfai, T. (2005). Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice. Neuroscience 133, 591-604.
  107. Brooks, D. G., Teyton, L., Oldstone, M. B. & McGavern, D. B. (2005). Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. Journal of virology 79, 10514-10527.
  108. Conti, B., Sugama, S., Lucero, J. & other authors (2005). Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. Journal of neurochemistry 93, 493-501.
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  110. Lu, X., Barr, A. M., Kinney, J. W., Sanna, P., Conti, B., Behrens, M. M. & Bartfai, T. (2005). A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proceedings of the National Academy of Sciences of the United States of America 102, 874-879.
  111. Lu, X., Lundstrom, L. & Bartfai, T. (2005). Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39, 165-167.
  112. Lu, X., Lundstrom, L., Langel, U. & Bartfai, T. (2005). Galanin receptor ligands. Neuropeptides 39, 143-146.
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  114. Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S. & Patapoutian, A. (2005). The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 15, 929-934.
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  119. Stinus, L., Cador, M., Zorrilla, E. P. & Koob, G. F. (2005). Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology 30, 90-98.
  120. Tabarean, I. V., Conti, B., Behrens, M., Korn, H. & Bartfai, T. (2005). Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture. Neuroscience 135, 433-449.
  121. Tabarin, A., Diz-Chaves, Y., Carmona Mdel, C. & other authors (2005). Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes 54, 3510-3516.
  122. Wirz, S. A., Davis, C. N., Lu, X., Zal, T. & Bartfai, T. (2005). Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides 39, 535-546.
  123. Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R. & Koob, G. F. (2005). Measuring meals: structure of prandial food and water intake of rats. American journal of physiology 288, R1450-1467.
  124. Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A. & Koob, G. F. (2005). Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology (Berl) 177, 324-335.
  125. Bartfai, T., Lu, X., Badie-Mahdavi, H., Barr, A.M., Mazarati, A, Hua, X.Y., Yaksh, T., Haberhauer, G., Ceide, S.C., Trembleau, L., Somogyi, L., Krock, L., Rebek J., Jr. Galmic A nonpeptide galanin receptor agonist, affects behaviors in seizure, pain and forced-swim tests. Proc Natl Acad Sci, USA, 101:(28);10470-5, 2004.
  126. Mazarati, A., Lu, X., Kilk, K., Langel, U., Wasterlain, C., Bartfai, T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizure: and seizure-induced neurogenesis in the dentate gyrus. Eur J of Neuroscience 19:(12);3235-44. 2004.
  127. Wirz, S.A., Morale, M.C., Marchetti, B., Barr, A.M., Sotgiu, S., Rosati, G., Pugliatti, M., Sanna, M.V., Giliberto, O., Bartfai, T., Conti, B. High frequency of TNF alleles -238A and -376A in individuals from northern Sardinia. Cytokine 26:(4);149-54, 2004.
  128. Oprica, M., Van Dam, A.M., Lundkvist, J., Iverfeldt, K., Winblad, B., Bartfai, T., Schultzberg, M. Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse. Acta Neuropathol (Berl), 108:(1);69-80, 2004.
  129. Bartfai, T. Pharmacogenomics in drug development: societal and technical aspects. Pharmacogenomics Journal 4:(4);226-32, 2004.
  130. Abramov, U., Floren, A., Echevarria, D.J., Brewer, A., Manuzon, H., Robinson, J.K., Bartfai, T., Vasar, E., Langel, U. Regulation of feeding by galnon. Neuropeptides 38:(1);55-61, 2004.
  131. Tabarean, I.V., Behrens, M.M., Bartfai, T., Korn, H. Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition. Proc Natl Acad Sci U S A 101:(8);2590-5, 2004.
  132. Conti, B., Tabarean, I., Andrei, C., Bartfai, T. Cytokines and Fever. Frontiers in Bioscience 9:1443-1449, 2004.
  133. Yoshitake, T., Wang, F.H., Kuteeva, E., Holmberg, K., Yamaguchi, M., Crawley, J.N., Steiner, R., Bartfai, T., Ogren, S.O., Hokfelt, T., Kehr, J. Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc Natl Acad Sci, USA 101:(1);354-9, 2004.
  134. Wu, W.P., Hao, J.X., Lundstrom, L., Wiesenfeld-Hallin, Z., Langel, U., Bartfai, T., Xu, X.J. Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Eur J Pharmacol. 15:482(1-3);133-7, 2003.
  135. Hua, X.Y., Hayes, C.S., Hofer, A., Fitzsimmons, B., Kilk, K., Langel, U., Bartfai, T., Yaksh, T.L. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 308:(2);574-82, 2003.
  136. Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M.M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C.L., Marinovich, M. Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 23:(25);8692-700, 2003.
  137. Hokfelt, T., Bartfai, T., Bloom, F. Neuropeptides opportunities for drug discovery. LANCET Neurology 2:463-72, 2003.
  138. Zachariou, V., Brunzell, D.H., Stedman, D.R., Hawes, J., Bartfai, T., Steiner, R.A., Wynick, D., Langel, U., Picciotto, M.R. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci, USA. 100:(15);9028-9033, 2003.
  139. Bartfai, T., Behrens, M.M., Gaidarova, S., Pemberton, J., Shivanyuk, A., Rebek, J., Jr. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Pro Natl Acad Sci, USA 100:(13);7971-6, 2003.
  140. Hertting, O., Khalil, A., Jaremko, G., Chromek, M., Li, Y.H., Bakhiet, M., Bartfai, T., Tullus, K., Brauner, A. Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1 beta-deficient mice. Clin Exp Immunol. 131:(2);225-33, 2003.
  141. Sugama, S., Cho, B.P., Baker, H., Joh, T.H., Lucero, J., Conti, B. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Research. Jul 26, 2002:958:1-9.
  142. Heidinger, V., Manzerra, P., Wang, X.Q., Strasser, U., Yu, S., Choi, D.W., Behrens, M.M. Metabotropic Glutamate Receptor 1-induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons. The Journal of Neuroscience. July 1, 2002: 22(13):5452-5461.
  143. Crawley, J.N., Mufson, E.J., Hohmann, J.G., Teklemichael, D., Steiner, R.A., Holmberg, K., Xu, Z.Q., Blakeman, K.H., Xu, X.J., Wiesenfeld-Hallin, Z., Bartfai, T., Hokfelt, T. Galanin overexpressing transgenic mice. Neuropeptides 36:(2-3);145-56, 2002.
  144. Pooga, M., Soomets, U., Bartfai, T., Langel, U. Synthesis of cell-penetrating peptide-PNA constructs. Methods Mol Biol. 208:225-36, 2002.
  145. Tehranian, R., Andell-Jonsson, S., Beni, S.M., Yatsiv, I., Shohami, E., Bartfai, T., Kundkvist, J., Iverfeldt, K. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma 19:(8);939-51, 2002.
  146. Bechmann, I., Diano, S., Warden, C.H., Bartfai, T., Nitsch, R., Horvath, T.L. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 64:363-7, 2002.
  147. Bal·spiri, L., Langel, U., Mazarati, A.M., B·rtfai, T. Galanin receptor ligand and antisense oligonucleotides in the study of hippocampal galanin receptors. Europeon Peptide Symposium, Sorrento, Italy 2002.
  148. Koob, G.F., Bartfai, T., Roberts, A.J. Molecular Genetic Approaches to the neuropharmacology of corticotrophin-releasing factor. Int. J. of Comparative Psych. 14:90-110, 2002.
  149. Gatti, S., Vezzani, A., Bartfai, T. Putative role of IL-1/IL-1ra in febrile seizures. In: Febrile Seizures (ed. Baram, T.Z., Shinnar, S.) Academic Press, San Diego, 2002.
  150. Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S.P., Hawkins, P.N. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417:254-9, 2002.
  151. Saar, K., Mazarati, A.M., Mahlapuu, R., Hallnemo, G., Soomets, U., Kilk, K., Hellberg, S., Pooga, M., Tolf, B.R., Shi, T.S., Hokfelt, T., Wasterlain, C., Bartfai, T., Langel, U. Anticonvuslant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci, USA 99:(10);7136-41, 2002.
  152. Locati, M., Deuschle, U., Massardi, M.L., Martinez, F.O., Sironi, M., Sozzani, S., Bartfai, T., Mantovani, A. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol. 168:3557-3562, 2002.
  153. Toro, V.C., Tehranian, R., Zetterstrom, M., Eriksson, G., Langel, U., Bartfai, T., Iverfeld, K. Increased gene expression of interleukin-1alpha and interleukin-6 in rat primary glial cells induced by beta-amyloid fragment. J Mol Neurosci. 17-3);341-50, 2001.
  154. Gatti, S., Beck, J., Fantuzzi, G., Bartfai, T., Dinarello, C.A. Effect of interleukin-18 on mouse core body temperature. Am J Physiol Regul Integr Comp Physiol. 282:(3);R702-9, 2002.
  155. Counts, S.E., Perez, S.E., Kahl, U., Bartfai, T., Bowser, R.P., Deecher, D.C., Mash, D.C., Crawley, J.N., Mufson, E.J. Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease. CNS Drug Rev., Review 7:(4);445-70, 2001.
  156. Mazarati, A., Langel, U., Bartfai, T. Galanin: an endogenous anticonvulsant? Neuroscientist 7:(6);506-17, 2001.
  157. Hallbrink, M., Floren, A., Elmquist, A., Pooga, M., Bartfai, T., Langel, U. Cargo delivery kinetics of cell-penetrating peptides. Biochim Biophys Acta 1515:(2);101-9, 2001.
  158. Kokaia, M., Holmberg, K., Nanobashvili, A., Xu, Z.Q., Kokaia, Z., Lendahl, U., Hilke, S., Theodorsson, E., Kahl, U., Bartfai, T., Lindvall, O., Hokfelt, T. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. Proc. Natl. Acad. Sci, USA 98:14006-11, 2001.
  159. Grundschober, C., Delaunay, F., Puelhofer, A., Triqueneaux, G., Laudet, V., Bartfai, T., Nef, P. Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. J. Biol. Chemistry 276:46751-8, 2001.
  160. Elmquist, A., Lindgren, M., Bartfai, T., Langel, U. VE-cadherin-derived cell-penetrating peptide, pVEC with carrier functions. Exp. Cell Res. 269:(2);237-244, 2001.
  161. Pramanik, A., Olsson, M., Langel, U., Bartfai, T., Rigler, R. Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells. Biochemistry 40:10839-45, 2001.
  162. Kostrewa, D., Brockhaus, M., D'Arcy, A., Dale, G.E., Nelboeck, P., Schmid, G., Mueller, F., Bazzoni, G., Dejana, E., Bartfai, T., Winkler, F.K., Hennig, M. X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif. EMBO J. 20:(16);4391-8, 2001.
  163. Kehr, J., Yoshitake, T., Wang, W.H., Wynick, D., Holmberg, K., Lendahl, U., Bartfai, T., Yamaguchi, M., Hokfelt, T., Ogren, S.O. Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. J Neurosci Methods 109:(1);71-80, 2001.
  164. Pooga, M., Kut, C., Kihlmark, M., Hollbrink, M., Fernaeus, S., Raid, R., Land, T., Hallberg, E., Bartfai, T., Langel, U. Cellular translocation of proteins by transportan. FASEB Journal 15:(8);1451-3, 2001.
  165. Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., Bartfai, T., Bargmann, C.I., Nef, P. Ca2+ signaling via the neuronal calcium sensor-1 regulated associative learning and memory in C. elegans. Neuron 30:(1);241-8, 2001.
  166. Pooga, M. Land, T., Bartfai, T., Langel, U. PNA oligomers as tools for specific modulation of gene expression. Biomol Eng. 17:(6);183-92, 2001.
  167. Bartfai T. Immunology: Telling the brain about pain. Nature 410:425-427, 2001.
  168. Blakeman, K.H., Holmberg, K., Hao, J.X., Xu, X.J., Kahl, U., Lendahl, U., Bartfai, T., Wiesenfeld-Hallin, Z., Hokfelt, T. Mice over-expressing galanin have elevated heat nociceptive threshold. Neuroreport 12:(2);423-5, 2001.
  169. Rezaei, K., Xu, I.S., Wu, W.P., Shi, T.J., Soomets, U., Land, T., Xu, X.J., Wiesenfeld-Hallin, Z., Hˆkfelt, T., Bartfai, T., Langel, U. Intratechal administration of PNA targeting galanin receptor reduces galanin-mediated inhibitory effect in the rat spinal cord. Neuroreport 12:(2);317-20, 2001.
  170. Jansson, A., Lippoldt, A., Mazel, T., Bartfai, T., Ogren, S.O., Sykova, E., Agnati, L.F., Fuxe, K. Long distance signalling in volume transmission. Focus on clearance mechanisms. Prog Brain Res.125:399-413, 2000.
  171. Khalil, A., Tullus, K., Bartfai T., Bakhiet, M., Jaremko, G., Brauner, A Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6-deficient mice. Clin Exp Immunol. 122:(2);200-6, 2000.
  172. Xu, X.J., Hokfelt, T., Bartfai, T., Wiesenfeld-Hallin, Z. Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications. Neuropeptides 34:137-147, 2000.
  173. Vezzani, A., Moneta, D., Conti, M., Richichi, C., Ravizza, T., De Luigi, A., De Simoni, M.G., Sperk, G., Andell-Jonsson, S., Lundkvist, J., Iverfeldt, K., Bartfai, T. Powerful anticonvulsant action of IL-1 receptor antagonist upon intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. USA 97:11534-9, 2000.
  174. Bazzoni, G., Martinez-Estrada, O.M., Mueller, F., Nelboeck, P., Schmid, G., Bartfai, T., Dejana, E., Brockhaus, M.Homophilic interaction of junctional adhesion molecule. J Biol Chem. 275:30970-6, 2000.
  175. Polentarutti, N., Bottazzi, B., Di Santo, E., Blasi, E., Agnello, D., Ghezzi, P., Introna, M., Bartfai, T., Richards, G., Mantovani, A. Inducible expression of the long pentraxin PTX3 in the central nervous system. J. Neuroimmunol. 106:87-94, 2000.
  176. Nalivaeva, N.N., Rybakina, E.G., Pivanovich, I-Yu., Kozinets, I.A., Shanin, S.N., Bartfai, T. Activation of neutral sphingomyelinase by IL-1beta requires the type 1 interleukin 1 receptor. Cytokine 12:229-32, 2000.
  177. Rezaei, K., Saar, K., Soomets, U., Valkna, A., Näsman, J., Zorko, M., Akerman, K., Schroeder, T., Bartfai, T., Langel, U. Role of third intracellular loop of galanin receptor type 1 in signal transduction. Neuropeptides 34:25-31, 2000.

 

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