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Harold L. Dorris
Neurological Research Institute
Tamas Bartfai
Noted neuroscientist Tamas Bartfai, Ph.D., is the director of the Harold L. Dorris Neurological Research Center at The Scripps Research Institute. In addition, he holds the Harold L. Dorris Chair in Neuroscience. The center was formed with a $10 million commitment from Helen L. Dorris of San Diego.
Professor Bartfai is former head of central nervous system research at Hoffman-La Roche, in Basel, Switzerland. Most of his professional career was spent in academia at Stockholm University, most recently as Chairman, Department of Neurochemistry and Neurotoxicity. Born in Budapest, Hungary, he received his undergraduate education there at Eotvos Lorand University and a Ph.D. in biochemistry at Stockholm
University. He has served as a visiting scientist at Hadassah-Hebrew University Medical School, Jerusalem; Yale University Medical School; and the Neuropsychiatric Institute at University of California, Los Angeles. Bartfai holds Adjunct Professor appointments at Rockefeller University and Stanford University.
Bartfai's work has been directed toward several scientific topics during his 27-year career in physiological chemistry. Most notably, he has made contributions in the fields of the molecular/biochemical basis of cognition, and the molecular/biochemical basis of fever. His work has implications for such diseases as depression, Alzheimer's disease, schizophrenia and sleep disorders. Involved in the development of psychopharmaceutical agents for the last 20 years, he developed Zimelidine, the first selective serotonin reuptake inhibitor (SSRI) and two anti-psychotic agents used in the treatment of schizophrenia.
Recently, he elucidated the molecular mechanism of a new kind of antidepressant, substance P antagonist, which modifies a previously untapped neurochemical system. This finding may lead to the development of new and more effective drug targets against depression, as well as anxiety disorders and schizophrenia. His work on the design, synthesis and biochemical and pharmacological application of the first galanin antagonists was essential for the elucidation of the biological effects of galanin in depression, cognition and pain, and led to the three galanin receptors becoming the target of more than 20 projects in the pharmaceutical industry.
The author of some 300 scientific publications, Bartfai is the recipient of numerous prestigious research awards, including the Eotvos Prize in Chemistry, the Svedberg Prize and the Eriksson Prize. In addition, he has been named a Senior Fullbright Fellow as well as a Fellow of The Neuroscience Institute.
The new center is designed to bring a dedicated effort to providing education and conducting research into neurological disorders, including schizophrenia and Alzheimer's disease, as well as advancing knowledge of the process of aging of the brain.
News and Views Article: Memory, Pain, Depression, and Peptides...Putting the Pieces Together
Curriculum Vitae
1948 Born in Budapest, Hungary
1966-1971 Studies in Physics and Chemistry at Eötvös Loránd University, Budapest
1971-1973 Graduate studies in Biochemistry at Stockholm University, Department of Biochemistry (Chairman Lars Ernster, supervisor Bengt Mannervik)
1973 Ph D; Biochemistry
1975 Associate Professor of Biochemistry (Docent), Stockholm University
1986- Professor of Biochemistry (especially Neurochemistry)
1992- Chairman; Department of Neurochemistry and Neurotoxicology, Stockholm University
1997- Head of Central Nervous System Research, Hoffmann-La Roche, Basel, on leave from Stockholm University, Roche, Basel,
1998 Stellvert.Vice direktör (Senior VP)
1998 Professor of Medicinal Chemistry, Karolinska Institutet, Stockholm, Sweden
1999 Placed as No 1, Chair of Neuropharmacology, Basel, Switzerland
2000 Professor, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA
2000 Director, The Harold L. Dorris Neurological Research Center, The Scripps Research Institute, La Jolla, CA
Ongoing Research Projects
Galanin a neuropeptide involved in cognition, pain and depression
Neurobiology of Fever
Interleukin-1 as a neuromodulator
Editorial Boards
Nature, Drug Discovery Mechanisms, Editor in Chief, Molecular Pharmacology, Editorial Board Referee European
Journal Neuroscience, Journal Neuroscience
Selected References
Bartfai, T. Ekwall, K. and Mannervik, B. Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I. Biochemistry 12, 387-391 (1973).
Bartfai, T., Anner, J., Schultzberg, M. and Montelius, J. Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex. Biochem. Biophys. Res. Commun. 59(2), 725-733 (1974).
Gatt, S. and Bartfai, T. Rate equations and stimulation curves for enzymatic reactions which utilize lipids as substrates. I. Interaction of enzymes with the monomers and micelles of soluble amphiphilic lipids. Biochim. Biophys. Acta 488, 1-12 (1977).
Järv, J., Hedlund, B. and Bartfai, T. Isomerization of the muscarinic receptor-antagonist complex. J. Biol. Chem. 254(13), 5595-5598 (1979).
Alberts, P., Bartfai, T. and Stjärne, L. Site(s) and ionic basis of a-autoinhibition and facilitation of [3H] noradrenaline secretion in guinea-pig vas deferens. J. Physiol. 312, 297-334 (1981).
Lundberg, J.M., Hedlund, B. and Bartfai, T. Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland. Nature 295, 147-149 (1982).
Hedlund, B., Abens, J. and Bartfai, T. Vasoactive intestinal polypeptide and muscarinic receptors: Supersensitivity induced by long-term atropine treatment. Science 220, 519-521 (1983).
Undén, A., Tatemoto, K., Mutt, V. and Bartfai, T. Neuropeptides Y receptor in the rat brain. Eur. J. Biochem. 145, 525-530 (1984).
Engström, O., Rodmalm, K., Jörnvall, H., Lundquist, G., Kalman, M., Simoncsits, A., Bartfai, T., Löfdahl, S. and Askelöf, A. Characterization of the N-terminal structure of pertussis toxin subunit Sl and hybridization of oligodeoxyribonucleotide probes with a Bordetella pertussis DNA fragment. FEMS Microbiol. Lett. 36, 219-223 (1986).
Fisone, G., Wu, C., Consolo, S., Nordström, ö., Brynne, N., Bartfai, T., Melander, T. and Hökfelt, T. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: Histochemical, autoradiographic, in vivo and in vitro studies. Proc. Natl. Acad. Sci. USA 84, 7339-7343 (1987).
Bartfai, T., Iverfeldt, K. and Fisone, G. Regulation of the release of coexisting neurotransmitters. Ann. Rev. Pharmacol. and Toxicol. 28, 285-310 (1988).
Askelöf, P., Rodmalm, K., Abens, J., Undén, A. and Bartfai, T. Use of synthetic peptides to map antigenic sites of Bordetella pertussis toxin subunit S1. J. Inf. Dis. 157(4), 738-742 (1988).
Fisone, G., Langel, U., Carlquist, M., Bergman, T., Consolo, S., Hökfelt, T., Undén, A., Andell, S. and Bartfai, T. Galanin receptor and its ligands in the rat hippocampus. Eur. J. Biochem. 181, 269-276 (1989).
Bartfai, T., Bedecs, K., Land, T., Langel, ü., Bertorelli, R., Girotti, P., Consolo, S., Xu, X., Wiesenfeld-Hallin, Z., Nilsson, S., Pieribone, V.A. and Hökfelt, T. M-15: High affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus and spinal cord. Proc. Natl. Acad. Sci. 88, 10961-10965 (1991).
Bartfai, T., Hökfelt,T. and Langel, ü. Galanin - a neuroendocrine peptide. Critical Reviews in Neurobiology 7(3/4):229-274 (1993).
Arvidsson, K., Land, T., Langel, ü., Bartfai, T. and Ehrenberg, A. Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. Biochemistry 32, 7787-7798 (1993).
Bartfai, T. Galanin: A neuropeptide with important CNS actions. In: Psychopharmacology: The Fourth Generation of Progress (F.E. Bloom and D.J. Kupfer, eds.) Raven Press, Ltd., New York, pp 563-571 (1995).
Alheim, K., Chai, Z., Fantuzzi, G., Hasanvan, H., Malinowsky, D., Di Santo, E., Ghezzi, P., Dinarello, C. and Bartfai, T. Hyperresponsive febrile reactions to interleukin (IL) 1a and IL-1b? and altered brain cytokine mRNA and serum cytokine levels, in IL-1b-deficient mice. Proc. Natl. Acad. Sci. 94, 2681-2686 (1997).
Östenson, C.-G., Zaitsev, S., Berggren, P.-O., Efendic, S., Langel, ü. and Bartfai, T. Galparan, a powerful insulin-releasing chimeric peptide acting at a novel site. Endocrinology 138, 3308-3313, (1998).
Pooga, M., Soomets, U., Hällbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J.-X., Xu, X.-J., Wiesenfeld-Hallin, Z., Hökfelt, T., Bartfai, T. and Langel, ü. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nature Biotechnology 16, 857-861 (1998).
Sundgren-Andersson, A.K., östlund, P. and Bartfai, T. IL-6 is essential in TNF-a-induced fever. Am. J. Physiol. 275, R2028-R2034 (1998).
Dinarello, CA, Gatti, S, Bartfai, T. Fever: links with an ancient receptor. Curr Biol. 9, R147-50 (1999).
Rezaei, K., Saar, K., Soomets, U., Valkna, A., Schroeder, T., Näsman, J., Zilmer, M., Åkerman, K., Zorko, M., Bartfai, T. and Langel, ü. Third intracellular loop of galanin receptor type 1 in signal transduction. Neuropeptides, 34:25-31, 2000.
Nalivaeva NN, Rybakina EG, Pivanovich IYu, Kozinets IA, Shanin SN, Bartfai T. Activation of neutral sphingomyelinase by IL-1beta requires the type 1 interleukin 1 receptor. Cytokine. 12:229-232, (2000).
Polentarutti N, Bottazzi B, Di Santo E, Blasi E, Agnello D, Ghezzi P, Introna M, Bartfai T, Richards G, Mantovani A. Inducible expression of the long pentraxin PTX3 in the central nervous system. J Neuroimmunol. 106:87-94, (2000).
Bazzoni G, Martinez-Estrada OM, Mueller F, Nelboeck P, Schmid G, Bartfai T, Dejana E, Brockhaus M. Homophilic interaction of Junctional Adhesion Molecule. J Biol Chem. 275:30970-6, (2000).
Vezzani, AM, Moneta, D, Conti, M, Richichi, C, Ravizza, T, De Luigi, A, De Simoni, MG, Sperk, G, Andell-Jonsson, S, Lundkvist, J, Iverfeldt, K, Bartfai, T. Powerful anticonvulsant action of IL-1 receptor antagonist upon intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. USA. 97:11534-9, (2000).
Xu, XJ, Hökfelt, T, Bartfai, T, Wiesenfeld-Hallin, Z. Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications. Neuropeptides. 34:137-147, (2000).
Jansson A, Lippoldt A, Mazel T, Bartfai T, Ogren SO, Sykova E, Agnati LF, Fuxe K. Long distance signalling in volume transmission. Focus on clearance mechanisms. Prog Brain Res.125:399-413, (2000).
Khalil A, Tullus K, Bartfai T, Bakhiet M, Jaremko G, Brauner A. Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6-deficient mice. Clin Exp Immunol. 122:200-206, (2000).
Jansson A, Lippoldt A, Mazel T, Bartfai T, Ogren SO, Sykova E, Agnati LF, Fuxe K. Long distance signalling in volume transmission. Focus on clearance mechanisms. Prog Brain Res. 2000;125:399-413.
Rezaei, K, Xu, IS, Wu, W-P, Shi, T-J, Soomets, U, Land, T, Xu, X-J, Wiesenfeld-Hallin, Z, Hökfelt, T, Bartfai, T, Langel, U. Intratechal administration of PNA targeting galanin receptor reduces galanin mediated inhibitory effect in the rat spinal cord. Neuroreport. 12:317-320, (2001).
Blakeman, K-H, Holmberg, K, Hao, J-X, Xu, X-J, Kahl, U, Lendahl, U, Bartfai, T, Wiesenfeld-Hallin, Z, Hökfelt, T. Mice overexpressing galanin have elevated heat nociceptive threshold. Neuroreport 12:423-425, (2001).
Bartfai T. Immunology: Telling the brain about pain. Nature. 410:425-427, (2001).
Gomez, M, De Castro, E, Guarin, E, Sasakura, H, Kuhara, A, Mori, I, Bartfai, T, Bargmann, C.I., Nef, P. Ca2+ signaling via the neuronal calcium sensor-1 regulated associative learning and memory in C. elegans. Neuron 30:241-248, (2001).
Kehr, J, Yoshitake, T, Wang, WH, Wynick, D, Holmberg, K, Lendahl, U, Bartfai, T, Yamaguchi, M, Hokfelt, T, Ogren, SO. Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. J Neurosci Methods 109:71-80, (2001).
Pramanik, A, Olsson, M, Langel, U, Bartfai, T, Rigler, R. Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells. Biochemistry 40:10839-10845, (2001).
Elmquist, A, Lindgren, M, Bartfai, T, Langel, U. VE-cadherin-derived cell-penetrating peptide, pVEC with carrier functions. Exp. Cell Res. 269:237-244, (2001).
Kokaia, M, Holmberg, K, Nanobashvili, A, Xu, ZQ, Kokaia, Z, Lendahl, U, Hilke, S, Theodorsson, E, Kahl, U, Bartfai, T, Lindvall, O, Hokfelt, T. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. Proc. Natl. Acad. Sci, USA 98:14006-14011, (2001).
Hallbrink, M, Floren, A, Elmquist, A, Pooga, M, Bartfai, T, Langel, U. Cargo delivery kinetics of cell-penetrating peptides. Biochim Biophys Acta 1515:101-109, (2001).
Mazarati, A, Langel, U, Bartfai, T. Galanin: an endogenous anticonvulsant? Neuroscientist 7:506-517, (2001).
Counts, SE, Perez, SE, Kahl, U, Bartfai, T, Bowser, RP, Deecher, DC, Mash, DC, Crawley, JN, Mufson, EJ. Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease. CNS Drug Rev., Review 7:445-470, (2001).
Gatti, S, Beck, J, Fantuzzi, G, Bartfai, T, Dinarello, CA. Effect of interleukin-18 on mouse core body temperature. Am J Physiol Regul Integr Comp Physiol. 282:R702-R709, (2002).
Toro, VC, Tehranian, R, Zetterstrom, M, Eriksson, G, Langel, U, Bartfai, T, Iverfeld, K. Increased gene expression of interleukin-1alpha and interleukin-6 in rat primary glial cells induced by beta-amyloid fragment. J Mol Neurosci. 17:341-350, (2001).
Locati, M, Deuschle, U, Massardi, ML, Martinez, FO, Sironi, M, Sozzani, S, Bartfai, T, Mantovani, A. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol. 168:3557-3562, (2002).
Saar, K, Mazarati, AM, Mahlapuu, R, Hallnemo, G, Soomets, U, Kilk, K, Hellberg, S, Pooga, M, Tolf, BR, Shi, TS, Hokfelt, T, Wasterlain, C, Bartfai, T, Langel, U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci, USA 99:7136-7141, (2002).
Pepys, MB, Herbert, J, Hutchinson, WL, Tennent, GA, Lachmann, HJ, Gallimore, JR, Lovat, LB, Bartfai, T, Alanine, A, Hertel, C, Hoffmann, T, Jakob-Roetne, R, Norcross, RD, Kemp, JA, Yamamura, K, Suzuki, M, Taylor, GW, Murray, S, Thompson, D, Purvis, A, Kolstoe, S, Wood, SP, Hawkins, PN. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417:254-259, (2002).
Gatti, S, Vezzani, A, Bartfai, T. Putative role of IL-1/IL-1ra in febrile seizures. In: Febrile Seizures (ed. Baram, T.Z., Shinnar, S.) Academic Press, San Diego, (2002).
Baláspiri, L, Langel, U, Mazarati, AM, Bartfai, T. Galanin receptor ligand and antisense oligonucleotides in the study of hippocampal galanin receptors. Europeon Peptide Symposium, Sorrento, Italy (2002).
Bechmann, I, Diano, S, Warden, CH, Bartfai, T, Nitsch, R, Horvath, TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 64:363-367, (2002).
Tehranian, R, Andell-Jonsson, S, Beni, SM, Yatsiv, I, Shohami, E, Bartfai, T, Kundkvist, J, Iverfeldt, K. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma 19:939-951, (2002).
Pooga, M, Soomets, U, Bartfai, T, Langel, U. Synthesis of cell-penetrating peptide-PNA constructs. Methods Mol Biol. 208:225-236, (2002).
Crawley, JN, Mufson, EJ, Hohmann, JG, Teklemichael, D, Steiner, RA, Holmberg, K, Xu, ZQ, Blakeman, KH, Xu, XJ, Wiesenfeld-Hallin, Z, Bartfai, T, Hokfelt, T. Galanin overexpressing transgenic mice. Neuropeptides 36:145-156, (2002).
Hertting, O, Khalil, A, Jaremko, G, Chromek, M, Li, YH, Bakhiet, M, Bartfai, T, Tullus, K, Brauner, A. Enhanced chemokine response in experimental acute Escherichia coli pyelonephritis in IL-1beta-deficient mice. Clin Exp Immunol. 131:225-233, (2003).
Bartfai, T, Behrens, MM, Gaidarova, S, Pemberton, J, Shivanyuk, A, Rebek, J, Jr. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Pro Natl Acad Sci, USA 100:7971-7976, (2003).
Zachariou, V, Brunzell, DH, Hawes, J, Stedman, DR, Bartfai, T, Steiner, RA, Wynick, D, Langel, U, Picciotto, MR. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci, USA 100:9028-9033, (2003).
Hökfelt, T, Bartfai, T, Bloom, F. Neuropeptides opportunities for drug discovery. LANCET Neurology 2:463-472, (2003).
Viviani, B, Bartesaghi, S, Gardoni, F, Vezzani, A, Behrens, MM, Bartfai, T, Binaglia, M, Corsini, E, Di Luca, M, Galli, CL, Marinovich, M. Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 23:8692-8700, (2003).
Hua, XY, Hayes, CS, Hofer, A, Fitzsimmons, B, Kilk, K, Langel, U, Bartfai, T, Yaksh, TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 308:574-582, (2003).
Wu, WP, Hao, JX, Lundstrom, L, Wiesenfeld-Hallin, Z, Langel, U, Bartfai, T, Xu, XJ. Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Eur J Pharmacol. 15:482;133-137, (2003).
Yoshitake, T, Wang, FH, Kuteeva, E, Holmberg, K, Yamaguchi, M, Crawley, JN, Steiner, R, Bartfai, T, Ogren, SO, Hokfelt, T, Kehr, J. Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc Natl Acad Sci, USA 101:354-359, (2004).
Conti, B, Tabarean, I, Andrei, C, Bartfai, T. Cytokines and Fever. Frontiers in Bioscience 1:1433-1449, (2004).
Tabarean, IV, Behrens, MM, Bartfai, T, Korn, H. Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition. Proc Natl Acad Sci, USA 101:2590-2595, (2004).
Abramov, U, Floren, A, Echevarria, DJ, Brewer, A, Manuzon, H, Robinson, JK, Bartfai, T, Vasar, E, Langel, U. Regulation of feeding by galnon. Neuropeptides 38:55-61, (2004).
Bartfai, T. Pharmacogenomics in drug development: societal and technical aspects. Pharmacogenomics Journal 4:226-232, (2004).
Oprica, M, Van Dam, AM, Lundkvist, J, Iverfeldt, K, Winblad, B, Bartfai, T, Schultzberg, M. Effects of chronic overexpression of interleukin-1 receptor antagonist in a model of permanent focal cerebral ischemia in mouse. Acta Neuropathol (Berl) 108:69-80, (2004).
Wirz, SA, Morale, MC, Marchetti, B, Barr, AM, Sotgiu, S, Rosati, G, Pugliatti, M, Sanna, MV, Giliberto, O, Bartfai, T, Conti, B. High frequency of TNF alleles-238A and -376A in individuals from northern Sardinia. Cytokine 26:149-154, (2004).
Mazarati, A, Lu, X, Kilk, K, Langel, U, Wasterlain, C, Bartfai, T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures: and seizure-induced neurogenesis in the dentate gyrus. Eur J of Neuroscience 19:3235-3244, (2004).
Bartfai, T, Lu, X, Badie-Mahdavi, H, Barr, AM, Mazarati, A, Hua, XY, Yaksh, T, Haberhauer, G, Ceide, SC, Trembleau, L, Somogyi, L, Krock, L, Rebek J, Jr. Galmic, a nonpeptide galanin receptor agonist, affects behaviours in seizure, pain and forced-swim tests. Proc Natl Acad Sci, USA 101:10470-10475, (2004).
Bartfai, T, et al. The State of GPCR Research in 2004: Nature Reviews Drug Discovery 3:577-626, (2004).
Mazarati, A. Lu, X, Shinmei, S, Badie-Mahdavi, H, Bartfai, T. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience 128:431-441, (2004).
Sugama, S, Wirz, SA, Barr, AM, Conti, B, Bartfai, T, Shibasaki, T. Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine treatment. Neuroscience 128:451-458, (2004).
Kilk, K, Elmquist A, Saar, K, Pooga, M, Land, T, Bartfai, T, Soomets, U, Langel, U. Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA. Neuropeptides 38:316-324, (2004).
Brunkhorst, A, Neuman, T, Hall, A, Arenas, E, Bartfai, T, Hermanson, O, Metsis, M. Novel isoforms of the TFIID subunit TAF4 modulate nuclear receptor-mediated transcriptional activity. Biochemical and Biophysical Research Communications, BBRC 325:574-579, (2004).
Ceide, SC, Trembleau, L, Haberhauer, G, Somogyi, L, Lu, X, Bartfai, T, Rebek, J, Jr. Synthesis of galmic: a nonpeptide galanin receptor agonist. Proc Natl Acad Sci USA 101:16727-16732, (2004).
Dube, C, Vezzani, A, Behrens, MM, Bartfai, T, Baram, TZ. Interleukin 1beta contributes to the generation of experimental febrile seizures. Ann Neurol. 57:152-155, (2004).
Lu, X, Barr, AM, Kinney, JW, Sanna, P, Conti, B, Behrens, MM, Bartfai, T. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc Natl Acad Sci USA 102:874-879, (2005).
Quynh, NT, Islam, SM, Floren, A, Bartfai, T, Langel, U, Ostenson, CG. Effects on galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochemical and Biophysical Research Communications, BBRC 328:213-220, (2005).
Sergeyev, V, Fetissov, S, Mathe, AA, Jimenez, PA, Bartfai, T, Mortas, P, Gaudet, L, Moreau, J-L, Hokfelt, T. Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology 178:115-124, (2005).
Kilk, K, El-Andaloussi, S, Jarver, P, Meikas, A, Valkna, A, Bartfai, T, Kogerman, P, Metsis, M, Langel, U. Evaluation of transportan 10 in PEI mediated plasmid delivery assay. J of Controlled Release 103:511-523, (2005).
Oprica, M, Zhu, S, Goiny, M, Pham, TM, Mohammed, AH, Winblad, B, Bartfai, T, Schultzberg, M. Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines. Brain Behav Immun. 19:223-234, (2005).
Conti, B, Sugama, S, Lucero, J, Winsky-Sommerer, R, Wirz, SA, Maher, P, Andrews, Z, Barr, AM, Morale, MC, Paneda, C, Pemberton, J, Gaidarova, S, Behrens, MM, Beal, F, Sanna, PP, Horvath, T, Bartfai, T. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. J Neurochem. 93:493-501, (2005).
Badie-Mahdavi, H, Lu, X, Behrens, MM, Bartfai, T. Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice. Neuroscience 133:591-604, (2005).
Holmberg, K, Kuteeva, E, Brumovsky, P, Kahl, U, Karlstrom, H, Lucas, GA, Rodriguez, J, Westerblad, H, Hilke, S, Theodorsson, E, Berge, OG., Lendahl, U, Bartfai, T, Hokfelt, T. Generation and phenotypic characterization of a galanin overexpressing mouse. Neuroscience 133:59-77, (2005).
Lu, X, Lundstrom, L, Langel, U, Bartfai, T. Galanin receptor ligands. Neuropeptides 39:143-146, (2005).
Lu, X, Mazarati, A, Sanna, P, Shimmei, S, Bartfai, T. Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides 39:147-152, (2005).
Sollenberg, U, Bartfai, T, Langel, U. Galnon - a low-molecular weight ligand of the galanin receptors. Neuropeptides 39:161-163, (2005).
Lu, X, Lundstrom, L, Bartfai, T. Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39:165-167, (2005).
Lundstrom, L, Lu, X, Langel, U, Bartfai, T. Important pharmacophores for binding to galanin receptor 2. Neuropeptides 39:169-171, (2005).
Hua, XY, Salgado, KF, Gu, G, Fitzsimmons, B, Kondo, I, Bartfai, T, Yaksh, T.L. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides 39:211-216, (2005).
Malkmus, S, Lu, X, Bartfai, T, Yaksh, TL, Hua, XY. Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides 39:217-221, (2005).
Badie-Mahdavi, H, Behrens, MM, Rebek, J, Jr., Bartfai, T. Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39:247-249, (2005).
Zheng, K, Kuteeva, E, Xia, S, Bartfai, T, Hokfelt, T, Xu, ZQ. Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice. Neuropeptides 39:257-265, (2005).
Pirondi, S, Kuteeva, E, Giardino, L, Ferraro, L, Antonelli, T, Bartfai, T, Ogren, SO, Hokfelt, T, Calza, L. Behavioral and neurochemical studies on brain aging in galanin overexpressing mice. Neuropeptides 39:303-310, (2005).
Lundstrom, L, Elmquist A, Bartfai, T, Langel, U. Galanin and its receptors in neurological disorders. Neuromolecular Med. 7:157-180, (2005).
Tabarean, IV, Conti, B, Behrens, MM, Korn, H, Bartfai, T. Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture. Neuroscience 135:433.449, (2005).
Wirz, SA, Davis, CN, Lu, X, Zal, T, Bartfai, T. Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides 39:535-546, (2005).
Floren, A, Sollenberg, U, Lundstrom, L, Zorko, M, Stojan, J, Budihna, M, Wheatley, M, Martin, N-P, Kilk, K, Mazarati, A, Bartfai, T, Lindgren, M, Langel, U. Multiple interaction sites of galnon trigger its biological effects. Neuropeptides 39:547-558, (2005).
Lu, X, Barr, AM, Bartfai, T. Galanin receptors as novel drug targets for the treatment of depression and anxiety. Drug Development Research 65:227-236, (2005).
Ostenson, CG, Gaisano, H, Sheu, L, Tibell, A, Bartfai, T. Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of Type 2 diabetic patients. Diabetes 55:435-440, (2006).
Kinney, JW, Davis, CN, Tabarean, I, Conti, B, Bartfai, T, Behrens, MM. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. J Neuroscience 26:1604-1615, (2006).
Bartfai, T, Lees, GV. Drug Discovery from beside to wall street: Legal drugs: Big business, your business. Drug Discovery Today, Elsevier, Book (2006).
Wirz, SA, Tobias, PS, Ulevitch, RJ, Aribibe, L, Bartfai, T. TLR2 is required for the altered transcription of p75NGF receptors in Gram positive infection. Neurochem Res. 31:297-301, (2006).
Sten-Shi, T-J, Hua, X-Y, Lu, X, Malkmus, S, Kinney, J, Holmberg, K, Wirz, S, Ceccatelli, S, Yaksh, T, Bartfai, T, Hokfelt, T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 23:627-636, (2006).
Sanchez-Alavez, M, Tabarean, IV, Behrens, MM, Bartfai, T. Ceramide mediates the rapid phase of febrile response to Interleukin-1. Proc Natl Acad Sci USA 103:2904-2908, 2006.
Davis, CN, Mann, E, Behrens, MM, Gaidarova, S, Rebek, M, Rebek, J, Jr., Bartfai, T. MyD88 dependent and independent signaling by IL-1 in neurons probed by bifunctional TIR domain/BB loop mimimetics. Proc Natl Acad Sci USA 103:2953-2958, (2006).
Sollenberg, UE, Lundstrom, L, Bartfai, T, Langel, U. M871-A novel peptide antagonist selectively recognizing the galanin receptor type 2. Int J Pep Res Ther. 12:115-119, (2006).
Davis, CN, Tabarean, IV, Gaidarova, S, Behrens, MM, Bartfai, T. IL-1 induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J Neurochem. 98:1379-1389, (2006).
Barr, AM, Kinney, JW, Hill, MN, Lu, X, Biros, S, Rebek, J, Jr., Bartfai, T. A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett. 405:111-115, (2006).
Robinson, JK, Bartfai, T, Langel, U. Galanin/GALP receptors and CNS homeostatic processes. CNS Neurol Disord Drug Targets 5:327-334, (2006).
Bartfai, T. From lab bench to Wall Street. FASEB J. 10:1578-80, (2006).
Shi, TJ, Hua, XY, Lu, X, Malkmus, S, Kinney, J, Holmberg, K, Wirz, S, Ceccatelli, S, Yaksh, T, Bartfai, T, Hokfelt, T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 23:627-636, (2006).
Tabarean, IV, Korn, H, Bartfai, T Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. Neuroscience 141:1685-1695, (2006).
Kovacs, Z, Kekesi, KA, Szilagyi, N, Abraham, I, Szekacs, D, Kiraly, N, Papp, E, Csaszar, I, Szego, E, Barabas, K, Peterfy, H, Erdei, A, Bartfai, T, Juhasz, G. Facilitation of spike-wave discharge activity by lipopolysaccharides in Wistar Albino Glaxo/Rijswijk rats. Neuroscience 140:731-742, (2006).
Conti, B, Sanchez-Alavez, M, Winsky-Sommerer, R, Morale, MC, Lucero, J, Brownell, S, Fabre, V, Huitron-Resendiz, S, Henriksen, S, Zorrilla, EP, de Lecea, L, Bartfai, T. Transgenic mice with a reduced core body temperature have an increased lifespan. Science 314:825-828, (2006).
Conti, B, Maier, R, Barr, AM, Morale, MC, Lu, X, Sanna, PP, Bilbe, G, Hoyer, D, Bartfai, T. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine, Molecular Psychiatry 12:167-189, (2007).
Sanchez-Alavez, M, Klein, I, Brownell, SE, Tabarean, IV, Davis, CN, Conti, B, Bartfai, T. Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci USA 104:3009-3014, (2007).
Zorrilla, EP, Brennan, M, Sabino, V, Lu, X, Bartfai, T. Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiol Behav. 91:479-485, (2007).
Bartfai, T, Sanchez-Alavez, M, Andell-Jonsson, S, Schultzberg, M, Vezzani, A, Danielsson, E, Conti, B. Interleukin-1 system in CNS stress: seizures, fever and neurotrauma, Ann N Y Acad Sci. 1113:173-177, (2007).
Lu, X, Sharkey, L, and Bartfai, T. The brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets 6:183-192, (2007).
Zorrilla, EP, Sanchez-Alavez, M, Sugama, S, Brennan, M, Fernandez, R, Bartfai, T, Conti, B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency, Proc Natl Acad Sci USA 104: 11097-11102, (2007).
Bartfai, T, Waalen, J, and Buxbaum, JN. Adipose tissue as a modulator of clinical inflammation: does obesity reduce the prevalence of rheumatoid arthritis? The Journal of Rheumatology 34:488-492, (2007).
Sanchez-Alavez, M, Bartfai, T. It all happens between Toll receptors and caspase 1. Proc Natl Acad Sci USA 104:7733-7734, (2007).
Lundström L, Sollenberg UE, Bartfai T, Langel U. Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions. J Neurochem. 103:1774-1784, (2007).
Bartfai, T, Lees, G. Drug Discovery, text book, Japanese edition, (2008).
Bartfai, T, Insel, T, Fishell, G, Rothwell, N. Choices in neuroscience careers. Nat Rev Neurosci. 9:401-405, (2008).
Spulber, S, Oprica, M, Bartfai, T, Winblad, B, Schultzberg, M. Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse. Eur J Neurosci. 27:549-558, (2008).
Buxbaum, JN, Ye, Z, Reixach, N, Friske, L, Levy, C, Das, P, Golde, T, Masliah, E, Roberts, AR, Bartfai, T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical Effects of Abeta toxicity. Proc Natl Acad Sci USA 105:2681-2686, (2008).
Sharkey, LM, Madamba, SG, Siggins, GR, Bartfai, T. Galanin alters GABAergic neurotransmission in the dorsal raphe nucleus. Neurochem Res. 33:285-291, (2008).
Mitsukawa, K, Lu, X, Bartfai, T. Galanin, galanin receptors and drug targets. Cell Mol Life Sci. 65:1796-1806, (2008).
Conti, B, Tabarean, I, Sanchez-Alavez, M, Davis, C, Brownell, S, Behrens, M, Bartfai, T. Cytokine receptors in the brain. In NeuroImmune Biology. Vol. 6: Cytokines and the Brain (C. Phelps and E. Korneva eds.) Amsterdam, The Netherlands 21-38, (2008).
Osborn, O, Brownell, SE, Sanchez-Alavez, M, Salomon, D, Gram, H, Bartfai, T. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine 44:141-148, (2008).
Balosso, S, Maroso, M., Sanchez-Alavez, M, Ravizza, T, Frasca, A, Bartfai, T, Vezzani, A. A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1. Brain 131:3256-3265, (2008).
Lu, X, Ross, B, Sanchez-Alavez, M, Zorrilla, EP, Bartfai, T. Phenotypic analysis of GalR2 knockout mice in anxiety and depression-related behavioral tests. Neuropeptides 42:387-397, (2008).
Osborn, O, Gram, H, Zorrilla, EP, Conti, B, Bartfai, T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly. 138:665-73, (2008).
Spulber, S, Mateos, L, Oprica, M, Cedazo-Minguez, A, Bartfai, T, Winblad, B, Schultzberg, M. Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J Neuroimmunol. 2009, 10.1016/j.jneurim.2009.01.010.
Lu, X, Bartfai, T. Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Arch Pharmacol. 379:417-420, (2009).
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