Scripps Research Logo

Chemical Physiology

Introduction

The goal of the Chemical Physiology Department is to discover, characterize, and eventually control the biochemical pathways that regulate higher-order physiological and pathological processes.  We are committed to creating innovative analytical and pharmacological tools to address biological problems at multiple levels of inquiry, toward the purpose of moving seamlessly from molecules to cellular pathways to living systems.  Emergent from these studies will be a detailed understanding of the chemistry of life, along with the requisite tools to probe pathways and restore their dysregulated states in human disease for therapeutic gain.

Specific examples of the research ongoing in the Chemical Physiology Department include:

  • development of mass spectrometry methods for the large-scale analysis of protein expression, modifications, and interactions
  • creation of microarray platforms for the global characterization of glycan-protein interactions
  • advancement of high-throughput, small-molecule screens to generate potent and selective pharmacological probes for proteins
  • development of chemical tools for profiling enzyme and small-molecule function in native biological systems
  • elucidation of the molecular, cellular, and (patho)physiological processes regulated by steroid hormone signaling pathways
  • determination of the role that nuclear hormone receptors play as integrators of higher-order metabolic states
  • investigation of the function of arginine post-translational modification in autoimmunity and other pathophysiological processes