Publications

  1. Modulating cell-surface receptor signaling and ion channel functions by in situ glycan editing. Jiang, H.; Meng, L.; Lopez-Aguilar, A.; Gao, Z.; Liu, Y.; Tian, X.; Yu, G.; Ovryn, B.; Moremen, K.W.; Wu P. Angew. Chem. Int. Ed. 2017, doi: 10.1002/anie.201706535 and 10.1002/ange.201706535.
  2. Profiling of Protein in O-GlcNAcylation in Murine CD8+ Effector- and Memory-like T cells. Aguilar Lopez, A., Gao, Y., Hou, X., Lauvau, G., Yates, J.R., Wu. P. ACS Chem. Biol. 2017, Nov 10. doi:10.1021/acschembio.7b00869.
  3. Inhibition of Delta-inducted Notch signaling using fucose analogs. Schneider, M.; Kumar, V.; Nordstørm, L.U.; Feng, L.; Takeuchi, H.; Hao, H.; Luca, V.C.; Garcia, K.C.; Stanley, P., Wu, P.*; Haltiwanger, R.S.* Nat. Chem. Bio. 2017, In press. (*co-corresponding authors).
  4. Bifluroide-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates. Gao, B.; Zhang, L.; Zheng, Q.; Zhou, F.; Klivansky, L.M.; Lu, J.; Liu, Y,.; Dong, J.; Wu, P.; Sharpless, K.B. Nat Chem. 2017, Nov;9(11):1083. doi:10.1038/nchem.2796.
  5. A chemoenzymatic histology method for O-GlcNAc detection. Lopez, A.A.; Hou, X.; Wen, L.; Wang, P.G.; and Wu, P.  Chembiochem. 2017, Oct 17. doi: 10.1002/cbic.201700515.Visualizing Glycans on Single Cells and Tissues.
  6. Fabrication of Photocontrolled Surfaces for Oil/Water Separation through Sulfur(VI) Fluoride Exchange. Zhu, H.; Chen, D.; Li, N.; Xu, Q.; Li, H.; He, J.; Wang, H.; Wu, P.; Lu, J. Chem. Eur. J. 2017, Oct 20;23(59):14712. doi: 10.1002/chem.201703309.
  7. SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts. Wang, H.;† Zhou, F.;† Ren, G.; Zheng, Q.; Chen, H.; Gao, B.; Klivansky, L.; Liu, Y.; Wu, B.; Xu, Q.; Lu, J.; Sharpless, K.B.; Wu, P.* Angew. Chem. Int. Ed. Engl. 2017, Sep 4;56(37):11203. doi: 10.1002/anie.201701160.
  8. An in vitro tag-and-modigy protein sample generation method for single-molecule fluorescence resonance engry transfer. Hamadani, K.M.; Howe J.; Jensen M.K.; Wu P.; Cate J.H.D.; Marqusee S.  J Biol Chem. 2017, Sep 22;292(38):15636. doi: 10.1074/jbc.M117.791723.
  9. Visualizing Glycans on single cells and tissues. Ovryn, B.; Hong, S.; Li, J.; Wu, P. Curr. Opin. Chem. Biol. 2017, 39, 39. 
  10. Palladium-Catalyzed Fluorosulfonylvinylation of Organic lodides. Zha, G.F.; Zheng, Q.; Leng, J.; Wu, P.; Qin, H.L.; Sharpless, K.B. Angew. Chem. Int. Ed. Engl. 2017, Apr 18;56(17):4849. doi: 10.1002/anie.201701162
  11. Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling. Lopez Aguilar, A.; Briard, J.G.; Yang, L.; Ovryn, B.; Macauley, M.S.; Wu, P. ACS Chem Biol. 2017, 12, 611.
  12. Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub. Li, S.; Wu, P.; Moses, J.E.; Sharpless, K.B. Angew. Chem. Int. Ed. Engl. 2017, 56, 2903.
  13. A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry. Qin, H.L.; Zheng, Q.; Bare, G.A.; Wu,P.*; Sharpless, K.B.*. (*co-corresponding authors) Angew Chem Int Ed Engl. 2016, Oct 10. doi: 10.1002/anie.201608807.
  14. Controlling Sulfuryl-Transfer Biology. Cook, I.; Wang, T.; Wang, W.; Kopp, F.; Wu, P.; Leyh, T. Cell Chem. Biol. 2016, 23, 579.
  15. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an FMOC Solid-phase Strategy. Chen, W.; Dong, J.; Li, S.; Liu, Y.; Wang, Y.; Poon, L.; Wu, P.; Sharpless, K.B.; Kelly, J.W. Angew. Chem. Int. Ed. 2016, 55, 1835.
  16. Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates. Zhang, E.; Tang, J.; Li, S.; Wu, P.; Moses, J.E.; Sharpless, K.B. Chem. Eur. J. 2016, 22, 5692.
  17. Discovery of Autophagy Inhibitors with Anti-proliferative Activity in Lung and Pancreatic Cancer Cells. Nordstrøm, L.; Sironi, J.; Aranda, E.; Maisonet, J.; Perez-Soler, R.; Wu, P.; Schwartz, E. ACS Med. Chem. Lett., 2015, 6, 134.
  18. Tracking Surface Glycans on Live Cancer Cells with Single Molecule Sensitivity. Jiang, H.; English, B.; Hazan, R.; Wu, P.*; Ovryn, B*. Angew. Chem. Int. Ed, 2015, 54, 1765. (*co-corresponding authors). Highlighted in C&EN News: “Single Glycoproteins Caught In Motion” 2015, 93 (1), 21.
  19. CHoMP: A Chemoenzymatic Histology Method for Glycan Detection Using ‘Clickable’ Probes. Rouhanifard, S. H.; López-Aguilar, A.; Wu, P. ChemBioChem. 2014, 15, 2667.
  20. Negative Feedback Regulator of Wnt Signaling via N-linked Fucosylation in Zebrafish. Feng, L.; Jiang, H.; Wu, P.*, Marlow, F.L.* Dev. Biol. 2014, 395, 268. (*co-corresponding authors).
  21. Biocompatible Click Chemistry Enabled Labeling of Cytosolic Proteins and Compartment-specific pH Indicators. Yang, M.; Jalloh, A.; Wei, W. Zhao, J.*; Wu. P*; Chen, P.R.* Nature Comm. 2014, 5, Article number: 4981; doi:10.1038/ncomms5981 (*co- corresponding authors). Highlighted in C&EN News: “Ligands Let Copper Click Inside Cells” 2014, 92 (39), 30.
  22. Monitoring Dynamic Glycosylation in Vivo Using Super-sensitive Click Chemistry. Jiang, H.; Zheng, T.; Lopez-Aguilar, A.; Feng, L.; Kopp, F.; Marlow, FL.; Wu, P. Bioconjugate Chem. 2014, 25, 698.
  23. In vivo chemistry. Bertozzi, C. R.; Wu, P. Curr. Opin. Chem, Biol. 2013, 17, 717.
  24. Single-stranded DNA as a Cleavable Linker for Bioorthogonal Click Chemistry-based Proteomics. Zheng, T.; Jiang, H.; Wu, P. Bioconjugate Chem. 2013, 24, 859.
  25. Chemical Probing of Glycans in Cells and Organisms. Rouhanifard, S. H.; Nordstrom, L. U.; Zheng, T.; Wu, P. Chem. Soc. Rev. 2013, 42, 4284.
  26. Detection and Isolation of Dendritic Cells Using Lewis X-functionalized Magnetic Nanoparticles.
    Rouhanifard, S. H.; Xie, R.; Zhang, G.; Sun, X.; Chen, X.; Wu, P. Biomacromolecules. 2012, 13, 3039.
  27. Click Triazoles for Bioconjugation. Zheng, T.; Rouhanifard S.H.; Jalloh A. S.; Wu P. Top. Heterocycl. Chem. 2012, 28,163.
  28. Metabolomic Analysis of Patient Plasma Yields Evidence of Plant-Like α-Linolenic Acid Metabolism in Plasmodium falciparum Lakshmanan, V.; Rhee, K. Y.; Wang, W.; Yu, Y.; Khafizov, K.; Fiser, A.; Wu, P.; Ndir, O.; Mboup, S.; Ndiaye, D.; Daily, J. P. J. Infect. Dis. 2012, 206, 238.
  29. Imaging the Glycome in Live Cells. Li, B.; Mock, F.; Wu, P. Meth. Enzymol. 2012, 505, 401.
  30. Sulfated ligands for the Copper(I)-catalyzed Azide-Alkyne Cycloaddition. Wang, W.; Hong, S.; Tran, A.; Jiang, H.; Triano, R.; Liu, Y. Chen, X.; Wu, P. Chem. Asian J. The “Click Chemistry 10 Years” Special Issue. 2011, 10, 2796.
  31. Metabolic Labeling of Fucosylated Glycoproteins in Bacteroides. Webler-Besanceney, C.; Jiang, H.; Wang, W.; Baughn, A.; Wu, P. Bioorg. Med. Chem. Lett. The special issue in honor of Prof. Carolyn Bertozzi on the occasion of her receiving Tetrahedron Young Investigator Award. 2011, 21, 4989.
  32. Imaging Glycans in Zebrafish Embryos by Metabolic Labeling and Bioorthogonal Click Chemistry. Jiang, H.; Feng, L.; Soriano del Amo, D.; Seidel, R.D. III; Marlow, F. Wu, P. J. Vis Exp. 2011, DOI: 10.3791/2686
  33. Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study
    Besanceney, C.; Jiang, H.; Zheng, T.; Feng, Lei; Soriano Del Amo, D.; Klivansky, L.; Liu, Y.; Marlow, F.; Wu, P. Angew. Chem. Int. Ed. 2011, 50, 8051.
  34. Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish. Dehnert, K. W.; Beahm, B. J.; Huynh, T. T.; Baskin, J. M.; Laughlin, S. T.; Wang, W.; Peng Wu, P.; Amacher, S. L.; Bertozzi, C. R.
    ACS Chem. Bio. 2011, 6, 547.LacNAc-Angew
  35. Tracking N-acetyllactosamine on Cell Surface Glycans in Vivo. Zheng, T.; Jiang, H.; Gros, M., Soriano del Amo, D.; Sundaram, S.; Lauvau, G.; Marlow, F.; Liu, Y., Stanley, P.; Wu, P. Angew. Chem. Int. Ed. 2011, 50, 4113.Fucosylation-JACS
  36. Biocompatible copper(I) catalysts for in vivo imaging of glycans. Soriano del Amo, D.; Wang, W.; Jiang, H.; Besanseney, C.; Yan, A, C.; Levy, M.; Liu, Y.; Marlow, F. Wu, P. J. Am. Chem. Soc. 2010, 132, 16893. Highlighted in C&EN News: “Imaging Molecules On Living Cells” 2010, 88 (48), 37.
  37. Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives. Soriano Del Amo, D.; Wang, W.; Besanceney, C.; Zheng, T; He, Y.; Gerwe, B.;Seidel, RD III, Wu, P. Carbohydr. Res. 2010, 345, 1107.
  38. Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Breidenbach, M. A.; Gallagher, J. E. G.; King, D. S.; Smart, B. P.; Wu, P.; Bertozzi, C. R. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 3988.
  39. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. Yap, M. C.; Kostiuk, M. A.; Martin, D. D.; Perinpanayagam, M. A.; Hak, P. C.; Siddam, A.; Majjigapu, J. R.; Rajaiah, G.; Keller, B. O.; Prescher, J. A.; Wu, P.; Bertozzi, C. R.; Falck, J. R.; Berthiaume, L. G. J. Lipid Res. 2010.
  40. Chemoenzymatic Synthesis of GDP-L-fucose and the Lewis X Glycan Derivatives. Wang, W.; Hu, T.; Frantom, P. A.; Zheng, T; Gerwe, B.; Soriano del Amo, D.; Seidel, R.D. III; Wu, P. Proc. Natl. Acad. Sci. 2009, 106, 16096.
  41. Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars. Chang, P.; Chen, X.; Smyrniotis, C.; Hu, T.; Bertozzi, C. R.; Wu, P. Angew. Chem. Int. Ed. 2009, 48, 4030.
  42. Glycopeptide preferring polypeptide- GalNAc transferase-10 (ppGalNAc T10), involved in mucin type-O-glycosylation, has a unique GalNAc-O-Ser/Thr binding site in its catalytic domain not found in ppGalNAc T1 or T2. Perrine, C. L.; Ganguli, A.; Wu, P.; Bertozzi, C. R.; Fritz, T.A.; Raman, J.; Tabak, L. A.; Gerken, T. A. J. Biol. Chem. 2009, 284, 20387.
  43. Site-specific Chemical Modification of Recombinant Proteins Produced in Mammalian Cells Using the Genetically Encoded Aldehyde Tag. Wu, P.; Shui, W.; Carlson, B.; Hu, N.; Rabuka, D.; Lee, J.; Bertozzi, C. R. Proc. Natl. Acad. Sci. 2009, 106, 3000.
  44. Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells. Chen, X. ; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A; Bertozzi, C. R. J. Am. Chem. Soc. 2009, 131, 890.
  45. Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers. Wu, P.; Chen, X. ; Hu, N.; Tam. U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. Angew. Chem. Int. Ed. 2008, 47, 5022.
  46. Role of architecture and molecular weight in the formation of tailor-made ultrathin multilayers using dendritic macromolecules and click chemistry. Vestberg, R.; Malkoch, M. Kade, M.; Wu, P.; Fokin, V. V.; Sharpless, K. B.; Drockenmuller, E; Hawker, C. J. J. Polym. Sci., Part A: Polym. Chem. 2007, 45, 2835.
  47. Catalytic Dipolar Cycloaddition of Azides and Alkynes: Reactivity and Applications. Wu, P.; Fokin, V. V. Aldrich. Acta. 2007, 40, 7.
  48. Osmium Catalyzed Olefin Dihydroxylation and Amino Hydroxylation with Second-Cycle Ligand. Wu, P.; Hilgraf, R.; Fokin, V. V. Adv. Synth. Catal. 2006, 348, 1079.
  49. Aziridines and Epoxides in Click Chemistry. Fokin, V. V.; Wu, P. in Aziridines and Epoxides in Organic Synthesis, Yudin, A. K. Ed., Wiley-VCH, New York, 2006, 443.
  50. Multivalent, Bifunctional Dendrimers Prepared by Click Chemistry. Wu, P.; Malkoch, M.; Hunt, J. N.; Vestberg, R.; Kaltgrad, E.; Finn, M. G.; Fokin, V. V.; Sharpless, K. B.; Hawker, C. J. Chem. Comm. 2005, 5775.
  51. Just Click It: Undergraduate Procedures for the Copper(I)-Catalyzed Formation of 1,2,3-Triazoles from Azides and Terminal Acetylenes. Sharpless, W. D.; Wu, P.; Hansen, T.; Lindberg, J. G. J. Chem. Educ. 2005, 82, 1833.
  52. One Pot Copper(I)-Catalyzed Syntheses of 3,5-Disubstituted Isoxazoles. Hansen, T.; Wu, P.; Fokin, V. V. J. Org. Chem. 2005, 70, 7761.
  53. Structurally Diverse Dendritic Libraries: A Highly Efficient Functionalization Approach Using Click Chemistry. Malkoch, M.; Schleicher, K.; Drockenmuller, E.; Hawker, C. J.; Russell, T. P.; Wu, P.; Fokin, V. V. Macromolecules. 2005, 38, 3663.
  54. Efficiency and Fidelity in a Click Chemistry Route to Triazole Dendrimers via the Cu(I)-Catalyzed Ligation of Azides and Alkynes. Wu, P.; Feldman, A. K.; Nugent, A. K.; Hawker, C. J.; Scheel, A.; Voit, B.; Pyun, J.; Frechet, J. M. J.; Sharpless, K. B.; Fokin, V.V. Angew. Chem. Int. Ed. 2004, 43, 3863.
  55. New d4 Dihydrides of Ru(IV) and Os(IV) with p-donor Ligands: M(H)2(chelate)(PiPr3)2 with Chelate = ortho-XYC6H4 with X, Y = O, NR; R = H or CH3 Ferrando-Miguel, G.; Wu, P.; Huffman, J. C.; Caulton, K. G. New J. Chem. 2005, 29, 193.
  56. Cu(I) and Cu(II) Complexes of a Pyridine-based Pincer Ligand. Vedernikov, A. N.; Wu, P.; Huffman, J. C.; Caulton, K. G. Inorg. Chim. Acta. 2002, 300, 103.