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Phinney Lab Publications

The following articles were published by Don Phinney, his lab members and his collaborators.

Boregowda SV, Ghoshal S, Booker CN, Krishnappa V, Chakraborty A, Phinney DG.  (2017)  IP6K1 Reduces Mesenchymal STem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.  Stem Cells.  [Epub ahead of print]

Phinney DG.  (2017)  Mesenchymal stromal cells and ischemic heart disease:  Hitting the target?  Cardiovasc Diagn Ther.  (3): E4-E6.

Phinney DG, Pittenger MF.  (2017)  Concise Review:  MSC-Derived Exosomes for Cell-Free Therapy.  Stem Cells.  (4):851-858.

Phinney DG. (2017)  Advancing mesenchymal stem/stromal cells-based therapies for neurologic disease.  Neural Regen Res.  (1):60-61.

Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD.  (2017)  Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.  J Am Chem Soc.  (9):3446-3455.

Isakova IA, Baker KC, Dufour J, Phinney DG.  (2017)  Mesenchymal Stem Cells Yield Transient Improvements in Motor Function of an Infant Rhesus Macaque with severe Early-Onset Krabee Disease.  Stem Cells Transl Med.  (1):99-109.

Haga, CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG.  (2017)  Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.  Methods Mol Biol.  1517:179-198.

Boregowda SV, Phinney DG. (2016)  Quantifiable Metrics for Predicting MSC Therapeutic Efficacy.  J Stem Cell Res Ther. (11)

Boregowda SV, Krishnappa V, Phinney DG. (2016)  Isolation of Mouse Bone Marrow Mesenchymal Stem Cells.  Methods Mol Biol.  1416:205-23.

Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD.  (2016)  Design of a small molecule against an oncogenic noncoding RNA.  Proc Natl Acad Sci USA.  113(21):5898-903.

Galipeau J, Krampera M, Barrett J, Dazzi F, Deans RJ, DeBruijn J, Dominici M, Fibbe WE, Gee AP, Gimble JM, Hematti P, Koh MB, LeBlanc K, Martin I, McNiece IK, Mendicino M, Oh S, Ortiz L, Phinney, DG, Planat V, ShiY", Stroncek DF, Viswanathan S, Weiss DJ, Sensebe L.  (2016) International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials.  Cytotherapy.  (2):151-9.

Phinney DG, Di Giuseppe M, Njah J, Sala E, Shiva S., St Croix CM, Stolz DB, Watkins SC, Di YP, Leikauf GD, Kolls J, Riches DW, Deiuliis G, Kaminski N, Boregowda SV, McKenna DH, Ortiz LA.  (2015)  Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.  Nat Commun.  6:8472.

Boregowda SV, Krishnappa V, Haga CL, Ortiz LA, Phinney DG.  (2015) A Clinical Indications prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells.  EBioMedicine.  4:62-73.

Pittenger MF, LeBlanc K, Phinney DG, Chan JK.  (2015) MSCs: Scientific Support for Multiple Therapies.  Stem Cells Int.  2015:280572.

Haga CL, Velagapudi SP, Strivelli JR, Yang WY, Disney MD, Phinney DG.  (2015) Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR  Signaling.  ACS Chem Biol. 10(10):2267-76.

Marciano, DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, Corzo CA, Khan TM, Novick SJ, Park H. Kojetin DJ, Phinney DG, Bruning JB, Kamenecka TM, Griffin PR.  (2015) Pharmacologial repression of PPARy promotes osteogenesis.  Nat Commun. 6:7443.

Phinney DG, Isakova IA. (2014) Mesenchymal stem cells as cellular vectors for pediatric neurological disorders. Brain Res. 1573:92-107.

Fazzi F, Njah J, Di Giuseppe MD, Winnica DE, Go K, Sala E, St. Croix CM, Watkins SC, TyurinVA, Phinney DG, Fattman CL, Leikauf GD, Kagan VE, Ortiz LA. (2014) TNFR1/PHOX interaction and TNFR1 mitochondrial translocation thwart silica-induced pulmonary fibrosis. J. Immunol. 192:3837-38-46.

Isakova IA, Lanclos C, Bruhn J, Kuroda M, Baker KC, Phinney DG. (2014) Allo-reactivity of mesenchymal stem cells in rhesus macaques is dose and haplotype dependent and limits durable cell engraftment in vivo. PLoSOne 9(1):e87238.   

Krishnappa V, Boregowda SV, Phinney DG. (2013) The peculiar biology of mouse mesenchymal stromal cells: Oxygen is the key. Cytotherapy 15:536-541.  

Phinney DG, Sensebe L. (2013) Mesenchymal stromal cells:  Misconceptions and evolving concepts. Cytotherapy 15:140-145.

Haga C, Phinney DG. (2012) MicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-to- mesenchymal transition by targeting the TWIST1 signaling pathway.  J. Biol. Chem.  287:42695-42707. 

Boregowda S, Phinney DG. (2012) Therapeutic applications of mesenchymal stem cells: current outlook. BioDrugs 26:201-208. 

Phinney DG. (2012) Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy. J. Cell. Biochem. 113:2806-2812.

Boregowda S, Krishnappa V, Chamber J, LoGrasso P, Lai W-T, Ortiz LA, Phinney DG. (2012)  Atmospheric oxygen inhibits growth and differentiation of marrow-derived MSCs via a p53-dependent mechanism: Implications for procurement methods that rely on long-term culture expansion of marrow cells.  Stem Cells 30:975-987.

O’Connor KC, Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE. (2011) High-capacity assay to quantify the clonal heterogeneity in potency of mesenchymal stem cells. BMC Proc. 5(Suppl 8):O14.

Lai WT, Krishnappa V, Phinney DG. Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels. Stem Cells 2011; 29:1102-1111.

Russell KC, Lacey MR, Gilliam JK, Tucker HA, Phinney DG, O’Connor KC. Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency. Biotechnol Bioeng. 2011; 108:2716-2726.

Phinney DG. Twist, epithelial-to-mesenchymal transition, and stem cells. Stem Cells 2011; 29:3-4.

Savitz SI, Chopp M, Deans R, Carmichael ST, Phinney D, Wechsler L. Stem cell therapy as an emerging paradigm for stroke (STEPS) II.  Stroke 2011; 42:825-829.

Adult Stem Cells: Biology and Methods of Analysis (2011). Edited by Phinney DG, Humana Press, New York, N.Y., USA

Prockop DJ, Brenner M, Fibbe WE, Horwitz E, Le Blanc K, Phinney DG, Simmons PJ, Senesbe L, Keating A. Defining the risks of mesenchymal stromal cell therapy. Cytotherapy 2010; 12:576-578.

Isakova IA, Dufour J, Lanclos C, Bruhn J, Phinney DG. Cell-dose-dependent increases in circulating levels of immune effector cells in rhesus macaques following intracranial injection of allogeneic MSCs. Exp. Hematol. 2010; 38:957-967.

Barrilleaux B, Fischer-Valuck BW, Gilliam JK, Phinney DG, O’Connor KC. Activation of CD74 inhibits migration of human mesenchymal stem cells. In Vitro Cell Dev Biol Anim. 2010; March 3 [Epub ahead of print].

Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O’Connor K C. In vitro high-capacity assay to quantify the clonal heterogeneity in tri-lineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells 2010; 28:788-798.

Barrilleaux BL, Phinney DG, Fischer-Valuck BW, Russell KC, Wang G, Prockop DJ, O’Connor KC. Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. Tissue Eng. Part A 2009; 15:2335-2346.

Phinney DG. A SAGE view of mesenchymal stem cells. Int. J. Stem Cells 2009; 2:1-10.

Phinney DG. Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion. Methods Mol. Biol. 2008; 449:171-186.

Phinney DG. (2008) Marrow Stem Cells, pp. 95-122 in Advances in Tissue Engineering. Edited by J. Polak, S. Mantalaris, and S. Harding, Imperial College Press, London.

Ortiz LA, DuTreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG. Interleukin 1 receptor antagonist mediates the anti-inflammatory and anti-fibrotic effect of mesenchymal stem cells during lung injury. Proc. Natl. Acad. Sci. USA 2007; 104:11002-11007.

Phinney DG. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 2007; 6:2884-2889.

Phinney DG, Prockop DJ. The state of trans-differentiation and modes of tissue repair: current views. Stem Cells 2007; 25:2896-2902.

Isakova IA, Baker K, Dufour J, Gaupp D, Phinney DG. Dose and age-related effects on MSCs engraftment levels and anatomical distribution in the CNS of non-human primates: Identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells 2007; 25:3261-3270.

Book Chapters:

Boregowda S, Phinney DG. (2012) Chapter 8, Mesenchymal stromal cells: Paracrine Effects, in Mesenchymal Stromal Cells: Basic Biology and Clinical Applications, Edited by P. Hematti and A. Keating, Springer P.O. Box 17, 3300 AA Dordrecht, The Netherlands.

Bellows C, Phinney DG. (2010) Chapter 77, Mesenchymal Stem Cells and Wound Repair, in Advances in Wound Care: Volume 1, Edited by C.K. Sen, Mary Ann Liebert, Inc., New Rochelle, NY.

Phinney DG. (2008) Marrow Stem Cells, pp. 95-122 in Advances in Tissue Engineering. Edited by J. Polak, S. Mantalaris, and S. Harding, Imperial College Press, London. 

Phinney DG. (2008) Isolation of murine mesenchymal stem cells by immunodepletion, vol. 449, pp. 171-186 in Methods in Molecular Biology, Molecular Medicine and Biotechnology: Adult Mesenchymal Stem Cells.  Edited by D. J. Prockop, B. A. Bunnell and D. G. Phinney, Humana Press Inc., Totowa, N.J. 

Phinney DG. (2006) Chapter 3, Gene expression profiles of mesenchymal stem cells, pp. 59-80 in Genetic Engineering of Mesenchymal Stem Cells, Edited by J. A. Nolta, Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands.  

Edited Books:

Adult Stem Cells: Basic Biology and Functional Characterization, 2011, Edited by DG Phinney, Springer, New York, NY.

Methods in Molecular Biology, Molecular Medicine and Biotechnology: Adult Mesenchymal Stem Cells, vol. 449, 2008. Edited by DJ Prockop, BA Bunnell and DG Phinney, Humana Press Inc., Totowa, NJ.