November 2009 View e-mail online
The Scripps Research Institute At the Forefront
An e-Newsletter for Philanthropists
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Focus On:
Professor Dwight Kono and co-author Argyrios Theofilopoulos Professor Dwight Kono (right) and co-author Professor Argyrios Theofilopoulos. Photo by Kevin Fung.


Identifying Lupus's Key Culprits

Lucy O'Donnell ascended to international fame at age four, when John Lennon's son painted a picture of her and took it home to his father, who was inspired to compose "Lucy in the Sky with Diamonds."

O'Donnell was never terribly fond of the song, but before her death from lupus this September at age 46, she tried to put that fame to use in fighting the disease that ultimately killed her.

To this day, lupus has no cure, but a recent finding by Scripps Research investigators brings us a step closer to that goal.
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Milestones in Medical Science:
The structure of P-glycoprotein. Image by Mitchell Duarte.
Decoding Chemotherapy Resistance

What can a doctor say when chemotherapy has failed? This grim situation is made worse by the fact that experts are more or less at a loss to explain why. Many of the key mechanisms behind chemotherapy drug resistance have been cloaked in mystery.

That is, until recently, when Scripps Research investigators were able to lift part of that cloak. The team's findings shed light on a key player in this mystery and offer up promising new possibilities for improving the efficacy of existing drugs.
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Other News:
Associate Professor Erica Ollmann Saphire overseeing research in West Africa
Tracking Ebola
Where do biomedical researchers go in search of knowledge about the workings of the human body and the viruses and diseases they fight?

Labs, mostly, and offices and hospitals. But for Scripps Research scientist Erica Ollmann Saphire, the key to understanding the deadly Ebola virus was meeting it in its den – the deep reaches of the African jungle. Just a few short months after her journey, she made headlines as the woman who broke open Ebola's secrets.
Facts & Figures
An estimated 1.5 million Americans, and at least 5 million people worldwide, have a form of lupus, and about 90% of those affected are women.
The Most Basic Blessing
When families gather to count their blessings, health often tops the list. It's what makes everything else possible, and it's what Scripps Research scientists dedicate their lives to improving. This year, do more than just say thank you – help secure this blessing for future generations.
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Join Scripps Research chemist and Associate Dean William Roush at Scripps Florida

The Link Between Graduate Education, Chemistry, and Biomedical Research: A Pathway that Impacts Society

Featuring William R. Roush, Ph.D., Professor of Chemistry, Associate Dean of the Kellogg School of Science and Technology, Executive Director of Medicinal Chemistry.

Wednesday, November 18, 2009
5:00 – 7:00
Scripps Florida
120 Scripps Way, Building B
Jupiter, Florida

Seating is limited, pre-registration is required. Please RSVP to Lisa L. Huertas
561-228-2015 lhuertas@scripps.edu
California: 10550 North Torrey Pines Road TPC2 - La Jolla CA 92037 - 858.784.2037
Florida: 130 Scripps Way 4B2 - Jupiter FL 33458 - 561.228.2015
email: philanthropy@scripps.edu - www.supportcures.org