The Scripps Research Institute - At The Forefront

August 2015

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Focus on:
A Leap Forward in Vaccinating Against HIV

HIV has the ability to evade detection by the human immune system and mutate rapidly into new strains, making traditional vaccine approaches that use a dead or inactive version of the virus ineffective. As a result, scientists have struggled to develop an effective vaccine for HIV for thirty years.

Now, a team of scientists led by researchers at The Scripps Research Institute (TSRI) has developed a new experimental vaccine candidate that can successfully stimulate the immune system activity necessary to stop HIV infection in animal models.

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Key author Dennis Burton of the new HIV/AIDS vaccine research from The Scripps Research Institute, International AIDS Vaccine Initiative and other institutions

TSRI's collaborative approach to research is developing groundbreaking advances for treating and preventing conditions like HIV and Alzheimer's, which affect millions of people worldwide. Help support our lifesaving work.

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Patrick Griffin chair of the Department of Molecular Therapeutics at Scripps Florida.

milestones in medical science:
A New Treatment Fights Bone Loss and Osteoporosis

A team of scientists at Scripps Florida has discovered a potential new treatment for osteoporosis and low bone mass – a condition that affects more than 54 million Americans over the age of 50.

The Scripps Research Institute team discovered that a single protein was stopping bone marrow stem cells from developing into new bone. The researchers then found a way to suppress that protein in mouse models that successfully increased their rate of bone growth – potentially promoting recovery from osteoporosis.

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Authors of the new study Germain U. Busto, Ron Davis and Tugba Guven-Ozkan.

Other News:
How Small RNA Helps Form Memories

In a new study, a team of scientists at Scripps Florida has found that a type of genetic material called "microRNA" plays surprisingly different roles in the formation of memory in animal models. In some cases, these RNAs increase memory, while in others they decrease it. Better understanding their impact on memory could lead to a better understanding of neurodegenerative diseases in humans, including Alzheimer's and Huntington's.

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Put Your Retirement Plan to Work for TSRI

Designate TSRI as a beneficiary on your retirement plan and avoid income tax and potential estate taxes while supporting our lifesaving research. You can continue to take regular withdrawals throughout your lifetime and change the beneficiary at any time. It's a simple, straightforward way for donors of all ages to avoid double taxation and make a difference at TSRI for years to come. Learn more today.

facts & figures

At the end of 2014, about 36.9 million people were living with HIV; that same year, 2 million people became newly infected and 1.2 million people died of AIDS-related causes.

The Scripps Research Institute

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