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October 2014

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Focus on:
A New Drug Candidate to Slow Tumor Growth

MYC is a transcriptional factor – meaning it controls gene expression – that regulates cancer. When MYC is overexpressed or amplified, the unregulated expression of genes involved in cell proliferation, a key step in cancer growth, follows. MYC is involved in a majority of cancers, including Burkitt's lymphoma, a fast-growing cancer that tends to strike children. It has been thought to be “undruggable” – until now.

A team at The Scripps Research Institute (TSRI) has discovered that
a credit card-like molecule they developed can move in and disrupt the critical interactions between MYC and its binding partner.

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“We finally hit a home run with this – maybe a grand slam,” says Professor Kim Janda.

TSRI's collaborative approach to research is discovering innovative new approaches to treat and cure cancer and other diseases that affect millions each day. Help support our life-saving work.

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A better understanding of the processes involved in the transition to alcohol dependence will foster novel strategies for prevention and therapy,” says Associate Professor Pietro Sanna.

milestones in medical science:
A Genetic Cause of Alcohol Dependence

Despite a clear genetic contribution to alcohol dependence, few risk genes have been identified, and, for those that have been pinpointed, the mechanisms of action that increased risk for alcohol dependence remained poorly understood.

Now, a team of TSRI scientists has
identified how a gene called neurofibromatosis type 1 (Nf1) plays a key role in the development of alcohol dependence. Their research could prove key to understanding how increased risk for alcoholism runs in families.

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TSRI Professor Matthew Disney.

Other News:
A Breakthrough in Treating ALS and Dementia

Amyotrophic lateral sclerosis (ALS), better known as Lou Gehrig's disease, is a progressive neurodegenerative disease that impacts nerve cells in both the brain and spinal cord. With this disease, an individual progressively loses voluntary muscle action and may eventually become completely paralyzed, and it is usually fatal two to five years after diagnosis.

An international team led by scientists from Scripps Florida and the Mayo Clinic have, for the first time, successfully
designed a therapeutic strategy targeting a specific genetic mutation that causes a common form ALS, as well as a type of frontotemporal dementia (FTD).

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Charitable Gift Annuities

You can transfer cash or securities to TSRI, and we will pay you, your spouse or any two beneficiaries you name fixed income for life. In many cases, the payments will receive a rate higher than the interest you are currently receiving. Plus, you will get an immediate income tax deduction and a portion of your annuity payment will be tax-free. The remaining balance passes to TSRI when the contract ends. Learn more here.

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facts & figures

Over 1.6 million Americans will be diagnosed with cancer in 2014, according to the American Cancer Society.

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