The Scripps Research Institute - At The Forefront

May 2014

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Focus on:
Progress Against Head, Neck and Lung Cancer

A team led by a scientist from Scripps Florida has identified a protein linked to higher rates of survival in patients with head, neck and non-small cell lung cancer, including patients who have not received chemotherapy – a treatment associated with toxic side effects.

The discovery could help scientists develop new diagnostics and therapies and help physicians determine the best long-term treatments for patients with these cancers.

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Peter Kuhn

TSRI Associate Professor
Laura Niedernhofer

Join us as we get closer to finding new treatments and cures for diseases like lung cancer and childhood respiratory disease that affect millions of people. Donate today and help us continue our work towards these life-saving medications.

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Marisa Roberto

Team leader William R. Schief (left), shown here with coauthor Research Associate Bruno E. Correia.

milestones in medical science:
Potential New Vaccine Could Prevent Infant Deaths

Some viruses, like HIV, influenza viruses and respiratory syncytial virus (RSV), effectively conceal the part of their structure that is vulnerable to antibodies, which makes it hard to design effective vaccines against them.

TSRI scientists have invented
a new method for designing artificial proteins and have used it to make key ingredients for a candidate vaccine against RSV, which is a significant cause of infant mortality. Their new “rational design” approach could also help develop vaccines for other viruses that have also been resistant to current vaccine-design strategies.

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Srini Subramaniam

The new study identified a new gene and a type of nerve cell required for detection of leg position. This image shows a stum-expressing sensory neuron in a leg joint.

Other News:
Balance Gene Discovered Thanks to Stumbling Fruit Flies

TSRI scientists have discovered an important mechanism underlying sensory feedback that guides balance and limb movements. The finding, which the TSRI team uncovered in fruit flies, centers on a gene and a type of nerve cell required for detection of leg-joint angles.

If the findings can be fully replicated in humans, they could lead to a better understanding of, and treatments for, disorders arising from faulty proprioception – the detection of body position.

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Creative D.I.Y. Fundraising to Benefit TSRI

In the past year, TSRI’s supporters have come up with many creative campaigns to support our lifesaving research. There was a campaign to climb Mount Kilimanjaro to support Parkinson’s research. A best-selling author raffled off the chance to name a character in her new novel. A middle-school student designed and sold key chains to benefit Alzheimer’s research. You, too, can do something you love to fight a disease or honor a loved one – from running a marathon to throwing a party! If you have a creative fundraising idea you would like to pursue, please contact Elliot Wolf at elliotw@scripps.edu.

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facts & figures

Lung cancer is the leading cause of cancer death among both men and women. More people die of lung cancer each year than of colon, breast and prostate cancers combined.

The Scripps Research Institute

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