The Scripps Research Institute - At The Forefront

September 2013

Connect with us:

facebook

twitter

youtube

Focus on:
Pinpointing a cause of Parkinson's

Parkinson's is the world's second-most common neurodegenerative disease, affecting about one million people in the United States alone. The absence of an enzyme known as parkin causes an early-onset form of Parkinson's disease, but precisely how the loss of this enzyme leads to the deaths of neurons has been unclear – until now.

A research team at The Scripps Research Institute (TSRI) has found that parkin's loss sharply reduces the level of another protein that normally helps protect neurons from stress. The discovery could lead to a new therapeutic strategy to treat Parkinson's.

Read More
http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-FOCUS-ON-READ-MORE-ARROW.jpg

Professor Steven I. Reed

Professor Steven I. Reed

TSRI's research is breaking new ground in treating and curing the world's most devastating diseases, including AIDS and Parkinson's. Help us continue our work towards these life-saving medications.

donate now

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR-VERTICLE.jpg

Human Glucagon Receptor

Human Glucagon Receptor

milestones in medical science:
3D Structure Offers Key Insights into Type 2 Diabetes

GPCRs (G protein-coupled receptors) are the largest family of cellular receptors in humans and other animals. More than a third of all modern pharmaceuticals target these receptors, either to boost or block their activities. Determining the structural details of individual GPCRs and how they interact with binding partners has therefore been a major goal of much biological research.

An international team led by scientists at TSRI has determined the three-dimensional atomic structure of the human glucagon receptor. The receptor helps regulate glucose levels in the bloodstream, and the discovery could lead to new treatments for type 2 diabetes.

Read More
http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-READ-MORE-ARROW.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR-VERTICLE.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR-VERTICLE.jpg

Associate Professor Laura Bohn

Associate Professor Laura Bohn

Other News:
Developing Drugs to Treat Addiction

Drugs of abuse often cause the brain to release large amounts of the neurotransmitter dopamine, which then flood the brain's reward system and reinforce the addictive cycle. These rewarding effects of misused drugs can be lowered with the help of compounds that activate the receptor that releases dopamine, the kappa opioid receptor (KOR), but this causes depression and sedation.

Researchers at Scripps Florida, led by TSRI Associate Professor Laura Bohn, have discovered new aspects of how the KOR behaves in the brain that could drive the development of new drugs to treat addiction as well as depression.

Read More
http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-READ-MORE-ARROW.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR-VERTICLE.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-GRAY-BAR.jpg

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-PLUS-BAR.jpg

Your Smartphone Can Help Fight AIDS

Android users can now download an app that will donate their smartphone's surplus computing power to finding new AIDS therapies through the FightAIDS@Home project. TSRI and IBM are using the massive computational power of the World Community Grid – a "virtual supercomputer" that uses donated processing power – to run millions of computations that evaluate interactions between compounds and mutant HIV viral proteins. A similar tool is also available for computers. Download the software at www.worldcommunitygrid.org.

http://contentz.mkt5124.com/ra/2013/45647/09/6923555/images_2013-TSRI-POUND-BAR.jpg

facts & figures

There is no cure for Parkinson's disease and it is the 14th leading cause of death in the US, according to the National Parkinson Foundation.

The Scripps Research Institute

donate now

California: 10550 North Torrey Pines Road, La Jolla, CA 92037 - (858) 784-2037
Florida: 130 Scripps Way, Jupiter, FL 33458 - (561) 228-2084

philanthropy@scripps.edu   •   www.supportcures.org

Charity Navigator

http://links.sankynet.mkt5124.com/open/log/6923555/NTcwOTI5MzYzMDMS1/0/ODc2ODI2NjIS1/1/0