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mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} </style> <![endif]--><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="1026"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--> </head> <body bgcolor="#396EB2" lang=EN-US link=blue vlink=purple style='tab-interval: .5in'> <div class=WordSection1> <p class=MsoNormal style='margin-left:120.0pt;text-indent:-120.0pt;tab-stops: 120.0pt;mso-layout-grid-align:none;text-autospace:none'><o:p></o:p></p> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=800 style='width:600.0pt;mso-cellspacing:0in;background:#396EB2;mso-yfti-tbllook: 1184;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:6.25in;mso-cellspacing:0in;mso-yfti-tbllook:1184'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> <td style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='font-size:7.5pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:white'>December 2010 </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> <td style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal align=right style='text-align:right'><span style='font-size:7.5pt;font-family:"Verdana","sans-serif";mso-fareast-font-family: "Times New Roman";color:white'><a href="http://www.kintera.org/TR.asp?a=jrKMJTOBIcLPIdI&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"></a> </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> </tr> </table> </div> </td> </tr> <tr style='mso-yfti-irow:1;height:3.75pt'> <td style='padding:0in 0in 0in 0in;height:3.75pt'></td> </tr> <tr style='mso-yfti-irow:2'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:6.25in;mso-cellspacing:0in;background:white;mso-yfti-tbllook: 1184;mso-padding-alt:0in 0in 0in 0in;background-image:initial;background-attachment: initial;background-origin: initial;background-clip: initial'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;mso-yfti-tbllook:1184;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><a href="http://www.kintera.org/TR.asp?a=mkISK2PNLfKWKnL&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><span style='text-decoration:none;text-underline:none'><img border=0 width=160 height=103 id="_x0000_i1025" src="https://www.kintera.com/AccountTempFiles/account106289/images/atflogo.jpg" alt="The scripps research institute"></span></a><o:p></o:p></span></p> </td> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><a href="http://www.kintera.org/TR.asp?a=fnJELHMlF8JJI3K&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><span style='text-decoration:none;text-underline:none'><img border=0 width=440 height=103 id="_x0000_i1026" src="https://www.kintera.com/AccountTempFiles/account106289/images/header.jpg" alt="At the forefront"></span></a><o:p></o:p></span></p> </td> </tr> </table> </div> </td> </tr> <tr style='mso-yfti-irow:1'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=600 style='width:6.25in;mso-cellspacing:0in;mso-yfti-tbllook:1184;mso-padding-alt: 0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes; height:12.75pt'> <td width=1 style='width:.75pt;padding:0in 0in 0in 0in;height:12.75pt'></td> <td width=598 style='width:448.5pt;background:#D7D5D5;padding:0in 0in 0in 0in; height:12.75pt;background-image:initial;background-attachment:initial; background-origin: initial;background-clip: initial'></td> <td width=1 style='width:.75pt;padding:0in 0in 0in 0in;height:12.75pt'></td> </tr> </table> </div> </td> </tr> <tr style='mso-yfti-irow:2;height:7.5pt'> <td style='padding:0in 0in 0in 0in;height:7.5pt'></td> </tr> <tr style='mso-yfti-irow:3;height:644.25pt'> <td style='padding:0in 0in 0in 0in;height:644.25pt'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;mso-yfti-tbllook:1184;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> <td valign=top style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;mso-yfti-tbllook:1184;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes; height:636.0pt'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in;height:636.0pt'></td> <td valign=top style='padding:0in 0in 0in 0in;height:636.0pt'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=394 style='width:295.5pt;mso-cellspacing:0in;mso-yfti-tbllook: 1184;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 width=394 height=22 id="_x0000_i1027" src="https://www.kintera.com/AccountTempFiles/account106289/images/divider.jpg" alt=Divider><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:1'> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><b><span style='font-size:10.5pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:#396EB2'>Years of discoveries </span></b><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:2;height:7.5pt'> <td style='padding:0in 0in 0in 0in;height:7.5pt'></td> </tr> <tr style='mso-yfti-irow:3'> <td style='padding:0in 0in 0in 0in'> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left style='mso-cellspacing:0in;mso-yfti-tbllook:1184; mso-table-lspace:2.25pt;mso-table-rspace:2.25pt;mso-table-anchor-vertical: paragraph;mso-table-anchor-horizontal:column;mso-table-left:left; mso-padding-alt:0in 0in 0in 0in' height=359> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;height:265.5pt'> <td width=122 style='width:91.5pt;padding:0in 0in 0in 0in; height:265.5pt'> <p class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'><a href="http://www.kintera.org/TR.asp?a=kiIOJWOFKeJLK9L&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><span style='text-decoration:none;text-underline:none'><img border=0 width=133 height=220 id="_x0000_i1028" src="https://www.kintera.com/AccountTempFiles/account106289/images/201011hiv.jpg"></span></a><br> </span><span style='font-size:7.5pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman"'>The structure of a human antibody that effectively acts against HIV</span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in;height: 265.5pt'></td> </tr> <tr style='mso-yfti-irow:1;mso-yfti-lastrow:yes;height:3.75pt'> <td colspan=2 style='padding:0in 0in 0in 0in;height:3.75pt'></td> </tr> </table> <p class=MsoNormal><span style='font-size:9.0pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:#396EB2'><!--<strong>Years of discoveries</strong><br /> -->Science is a slow, often incremental process, and when you're working to cure deadly diseases, it can never go fast enough. <br> <br> It may not feel like it every day, but The Scripps Research Institute's scientists are making phenomenal headway on the most pressing medical fronts. This year, Scripps Research teams have mapped the structure of human antibodies that could help form the basis for an HIV vaccine, pinpointed molecular mechanisms behind the compulsion to overeat, and discovered a promising new drug candidate to treat malaria. <br> <br> This time of year, we like to step back and take the <a href="http://www.kintera.org/TR.asp?a=nvKUK5PRJhISLjK&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><strong><span style='font-family:"Verdana","sans-serif";color:#396EB2'>wide-angle view of the advances that will redefine tomorrow's medical treatments.</span></strong></a> <!--<a href="#" style="color:#396eb2;"><strong>Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</strong></a>.--><br> <br> <a href="http://www.kintera.org/TR.asp?a=goLGLKNpHaLFJZJ&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><strong><span style='font-family:"Verdana","sans-serif";color:#396EB2'>Read More </span></strong></a> </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:4;height:15.0pt'> <td style='padding:0in 0in 0in 0in;height:15.0pt'></td> </tr> <tr style='mso-yfti-irow:5'> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 width=394 height=22 id="_x0000_i1029" src="https://www.kintera.com/AccountTempFiles/account106289/images/divider.jpg" alt=Divider><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:6'> <!-- <td> <span style="font-family:verdana;font-size:14px;font-weight:bold;color:#396eb2"> Milestones in Medical Science </span> </td> --> <td style='padding:0in 0in 0in 0in'></td> </tr> <tr style='mso-yfti-irow:7;height:7.5pt'> <td style='padding:0in 0in 0in 0in;height:7.5pt'></td> </tr> <tr style='mso-yfti-irow:8'> <td style='padding:0in 0in 0in 0in'> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=right style='mso-cellspacing:0in;mso-yfti-tbllook:1184; mso-table-lspace:2.25pt;mso-table-rspace:2.25pt;mso-table-anchor-vertical: paragraph;mso-table-anchor-horizontal:column;mso-table-left:right; mso-table-top:middle;mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in'></td> <td width=153 style='width:114.75pt;padding:0in 0in 0in 0in'> <p class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'><a href="http://www.kintera.org/TR.asp?a=jhJMLTOBJdKML9I&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><span style='text-decoration:none;text-underline:none'><img border=0 width=155 height=209 id="_x0000_i1030" src="https://www.kintera.com/AccountTempFiles/account106289/images/201012scientists2.jpg"></span></a><br style='mso-special-character:line-break'> <![if !supportLineBreakNewLine]><br style='mso-special-character: line-break'> <![endif]><o:p></o:p></span></p> </td> </tr> <!--<span style="font-family:verdana;font-size:10px;"> Lorem ipsum dolor </span>--> <tr style='mso-yfti-irow:1;mso-yfti-lastrow:yes;height:3.75pt'> <td colspan=2 style='padding:0in 0in 0in 0in;height:3.75pt'></td> </tr> </table> <p class=MsoNormal><strong><span style='font-size:9.0pt;font-family: "Verdana","sans-serif";mso-fareast-font-family:"Times New Roman"; color:#396EB2'>What budget cuts mean for biomedical research</span></strong><span style='font-size:9.0pt;font-family:"Verdana","sans-serif";mso-fareast-font-family: "Times New Roman";color:#396EB2'><br> <br> With federal budget cuts being considered across the board, medical research could be next. The National Institutes of Health (NIH) chief, Francis Collins has warned of leaner federal budgets ahead, with the possibility that the current historically low success rates for grant applications could drop even further, possibly to as low as 10 percent. <br> <br> Scripps Research has always relied on private philanthropy to fund the high-risk, high-reward studies that are too speculative for federal funding but can lead to major breakthroughs. Private money acts as seed funding, helping to develop new ideas, treatments, and technologies enough to later capture an NIH grant. <br> <br> In this funding environment, private donations to biomedical research are more important than ever. <a href="http://www.kintera.org/TR.asp?a=mkLSI2PNIgJTJjL&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><strong><span style='font-family:"Verdana","sans-serif";color:#396EB2'>Please make your gift to Scripps Research today</span></strong></a>.<br> <br> <a href="http://www.kintera.org/TR.asp?a=geIGJKMpGaIIL2J&amp;s=mmJ7IfNYIlKTJaOXKuG&amp;m=brKMLXPHLlLULdJ"><strong><span style='font-family:"Verdana","sans-serif";color:#396EB2'>Donate Now </span></strong></a> </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:9;height:6.0pt'> <td style='padding:0in 0in 0in 0in;height:6.0pt'></td> </tr> <!-- <tr> <td> <img src="https://www.kintera.com/AccountTempFiles/account106289/images/divider.jpg" width="394" height="22" alt="Divider" style="display:block;border:none;" /> </td> </tr> --><!-- <tr> <td> <span style="font-family:verdana;font-size:14px;font-weight:bold;color:#396eb2"> Other News </span> </td> </tr> --> <tr style='mso-yfti-irow:10;height:1.5pt'> <td style='padding:0in 0in 0in 0in;height:1.5pt'></td> </tr> <tr style='mso-yfti-irow:11'> <td style='padding:0in 0in 0in 0in'><!-- <span style="font-family:verdana;font-size:12px;color:#396eb2;"> <strong>Lorem ipsum dolor</strong><br /> sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum. <br /> <br /> Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. <a href="#" style="color:#396eb2;"><strong>Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</strong></a>.<br /> <br /> <a href="#" style="color:#396eb2;"><strong>Read More &raquo;</strong></a> </span> --></td> </tr> <tr style='mso-yfti-irow:12;mso-yfti-lastrow:yes;height:1.5pt'> <td style='padding:0in 0in 0in 0in;height:1.5pt'></td> </tr> </table> </div> </td> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in;height:636.0pt'></td> <!-- RIGHT SIDE CONTENT --> <td valign=top style='background:#CCD9EB;padding:0in 0in 0in 0in; height:636.0pt;background-image:initial;background-attachment:initial; background-origin: initial;background-clip: initial'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;background:#396EB2;mso-yfti-tbllook:1184; mso-padding-alt:0in 0in 0in 0in;background-image:initial;background-attachment: initial;background-origin: initial;background-clip: initial'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;height:3.75pt'> <td style='padding:0in 0in 0in 0in;height:3.75pt;background-image: initial;background-attachment:initial;background-origin: initial; background-clip: initial'></td> </tr> <tr style='mso-yfti-irow:1'> <td style='padding:0in 0in 0in 0in'> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 align=left style='mso-cellspacing:0in;mso-yfti-tbllook:1184; mso-table-lspace:2.25pt;mso-table-rspace:2.25pt;mso-table-anchor-vertical: paragraph;mso-table-anchor-horizontal:column;mso-table-left:left; mso-padding-alt:0in 0in 0in 0in'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow: yes'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in'></td> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='font-size:10.5pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:white'>Facts &amp; Figures </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> </tr> </table> </td> </tr> <tr style='mso-yfti-irow:2;height:.75pt'> <td style='padding:0in 0in 0in 0in;height:.75pt'></td> </tr> <tr style='mso-yfti-irow:3'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;background:#CCD9EB;mso-yfti-tbllook:1184; mso-padding-alt:0in 0in 0in 0in;background-image:initial;background-attachment: initial;background-origin: initial;background-clip: initial'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;height:3.75pt'> <td style='padding:0in 0in 0in 0in;height:3.75pt'></td> </tr> <tr style='mso-yfti-irow:1;mso-yfti-lastrow:yes'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;background:#CCD9EB;mso-yfti-tbllook: 1184;mso-padding-alt:0in 0in 0in 0in;background-image:initial; background-attachment:initial;background-origin: initial; background-clip: initial'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in'></td> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='font-size:9.0pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:#396EB2'>Scripps Research scientists are actively investigating biological and chemical aspects of more than <strong><span style='font-family: "Verdana","sans-serif"'>40 diseases</span></strong> as a first step in the drug development pipeline. </span><span style='mso-fareast-font-family:"Times New Roman"'><o:p></o:p></span></p> </td> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in'></td> </tr> <tr style='mso-yfti-irow:1;mso-yfti-lastrow:yes;height:7.5pt'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in; height:7.5pt'></td> <td style='padding:0in 0in 0in 0in;height:7.5pt'></td> <td style='padding:0in 0in 0in 0in;height:7.5pt'></td> </tr> </table> </div> </td> </tr> </table> </div> </td> </tr> <tr style='mso-yfti-irow:4;height:.75pt'> <td style='background:white;padding:0in 0in 0in 0in;height:.75pt; background-image:initial;background-attachment:initial;background-origin: initial; background-clip: initial'></td> </tr> <tr style='mso-yfti-irow:5'> <td style='padding:0in 0in 0in 0in'> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='mso-cellspacing:0in;background:#FA7C10;mso-yfti-tbllook:1184; mso-padding-alt:0in 0in 0in 0in;background-image:initial;background-attachment: initial;background-origin: initial;background-clip: initial'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;height:11.25pt'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in;height: 11.25pt'></td> <td style='padding:0in 0in 0in 0in;height:11.25pt'></td> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in;height: 11.25pt'></td> </tr> <tr style='mso-yfti-irow:1'> <td width=10 style='width:7.5pt;padding:0in 0in 0in 0in'></td> <td style='padding:0in 0in 0in 0in'> <p class=MsoNormal><span style='font-size:10.5pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman";color:white'>Make your tax-deductible gift today </span><span style='mso-fareast-font-family: "Times New Roman"'><br> <br> </span><span style='font-size:9.0pt;font-family:"Verdana","sans-serif"; mso-fareast-font-family:"Times New Roman"'>The year is almost over, but there's still time to take advantage of a 2010 tax benefit. 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