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Focus
On
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Philanthropists
Arnold and Arlene Goldstein
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A
Patient Giving Back
Arnold
Goldstein got to see Professor Jeffery Kelly's work on
protein folding disorders first hand. As a patient with
amyloidosis, he enrolled in the clinical trials for a
new drug being developed from the Kelly lab's initial
research. Amyloidosis causes a range of debilitating
diseases, as misfolded proteins dangerously deposit in
organs, including the brain.
Impressed with what
he saw, Goldstein, a New York businessman, made a gift
to Scripps Research that will expand the research and
enable the institute to hire a new researcher whose work
will focus on developing
the next generation of drugs to treat amyloidosis.
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Milestones
in Medical
Science
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John
Cleveland |
New
Hope from an Old Drug for Fighting Childhood Cancer
Thirty
years ago, a promising cancer-fighting drug was shelved
because of toxicity concerns. But John Cleveland, chair
of the Scripps Florida Department of Cancer Biology,
didn't give up on it so quickly.
Running tests
using small doses, his team found that "it likely works
in a large cast of tumors, even those having poor
prognosis, like high-risk neuroblastoma," one of the
most devastating cancers among young children.
When other researchers had turned their
attention elsewhere, Cleveland's team at Scripps
Research investigated the biomedical foundation of the
shelved drug and is
providing new knowledge about potential drug
pathways.
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Other
News
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Backbone
structures of SUMO (green) superimposed on Rad60
(blue) |
Mimicry's
Role in Genome Integrity
Genome
replication is a critical but fragile moment in an
organism's health. At least 160 different proteins are
involved in the replication of the human genome, and
errors can promote tumors, aging, and neurodegenerative
disorders like Alzheimer's, Parkinson's, and
Huntington's diseases.
Now,
Scripps Research scientists have brought understanding
of the process one step forward by identifying an enzyme
using mimicry as playing a part in the
process. |
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