The Scripps Research Institute - At The Forefront
July 2015 Connect with us:
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How a Brain Protein Triggers Binge Drinking

A team of scientists at The Scripps Research Institute (TSRI) has discovered that a brain protein plays a key role in controlling binge drinking. In the study, the team found that deleting the gene for this protein in mice ramped up alcohol consumption and prevented the brain from signaling the rewarding properties of alcohol. The results also showed that boosting the protein may prevent drinking to the point of intoxication.

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Scripps Research Institute Assistant Professor Candice Contet and Research Associate Melissa Herman were among the authors of the new paper.
TSRI’s collaborative approach to research creates new treatments for diseases like cancer and alcoholism, which affect millions of people each day. Help support our life-saving work. donate now
 
Ben Shen is a professor at the Florida campus of The Scripps Research Institute.
milestones in medical science:
Can A Natural Response to Cellular Stress Fight Cancer?

Naturally occurring compounds known as "antitumor antibiotics" are known to impede cancer cell growth and multiplication, and some are already in use as chemotherapy agents.

Recently, scientists from Scripps Florida, led by Ben Shen, vice chair of TSRI's Department of Chemistry, found that an antitumor antibiotic called leinamycin (LNM) E1 can be activated by one of the body's natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells, proving it has the potential to serve as a new cancer therapy.

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Lisa Stowers, Associate Professor with Research Associate Sandeepa Dey.
Other News:
A Hormone Can Blind Female Mice to the Smell of Males

Everyone knows that a plate of food doesn’t look as delicious after you’ve already eaten a big meal. But imagine if your internal state actually made you blind to food.

In a new study, TSRI scientists found that when female mice are in are in diestrus, a period of sexual inactivity during the reproductive cycle, receptors in their nose cause an odor “blindness” by blocking the pheromone signals from male mice and preventing them from ever reaching the females’ brains. The results could enable a better understanding of how pheromones work, possibly even in humans.

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Tess Gerritsen’s ‘War on Alzheimer’s’ Returns

Bestselling author Tess Gerritsen is raffling off the right to name a character in her next Rizzoli & Isles novel, slated for release in 2016. The campaign runs from June through November, and all proceeds will fund TSRI’s groundbreaking Alzheimer’s research. Gerritsen, whose books served as an inspiration for TNT’s Rizzoli & Isles television series, has pledged to match all donations up to $25,000. Her 2013 War on Alzheimer’s campaign raised more than $50,000 for TSRI. Enter the raffle here.
facts & figures

Approximately 88,000 Americans die from alcohol-related causes annually, making it the third leading preventable cause of death in the United States.
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