The Scripps Research Institute - At The Forefront
February 2015 Connect with us:
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A Better Vaccine to Help Smokers Quit?

Smoking is the leading cause of eight types of cancer, including lung cancer and fast-moving pancreatic cancer. A vaccine that can block nicotine from entering the brain could help people trying to quit smoking from relapsing; however, a past attempt at designing a vaccine only proved successful in 30% of patients.

Now, a team of scientists at The Scripps Research Institute (TSRI) has designed a new, more effective nicotine vaccine that could help smokers quit for good. The researchers also revealed insights that could be used in designing other vaccines against drugs of abuse.

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Kim Janda is the Ely R. Callaway Jr. Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at The Scripps Research Institute.
TSRI's collaborative approach to research is breaking new ground in the fight against diseases such as cancer and addiction that affect millions around the world each day. Help us continue our life-saving work. donate now
 
Patrick Griffin is chair of The Scripps Research Institute Department of Molecular Therapeutics and director of the Translational Research Institute at Scripps Florida.
milestones in medical science:
A New Compound to Treat Breast and Pancreatic Cancer

A protein called “liver receptor homolog-1,” or LRH-1, has been shown to play an important role in the progression of breast and pancreatic cancer. Scientists from Scripps Florida have identified a novel synthetic compound known as SR1848 that sharply reduces the activity and expression of this cancer-related protein, potentially helping fight tumors that are non-responsive to standard therapies.

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Paul Schimmel, PhD, is a professor and member of the Skaggs Institute for Chemical Biology at The Scripps Research Institute.
Other News:
Explaining Red Wine's Health Benefits

Scientists have long hypothesized that the antioxidant resveratrol, the red-wine ingredient sometimes touted as an elixir of youth, could make humans live longer. However, previous studies had suggested the amount of resveratrol needed to produce beneficial effects far exceeded the amount available through moderate consumption of red wine.

Now a TSRI team has discovered that resveratrol activates an ancient stress response mechanism in human cells that guards against DNA damage – a finding that should dispel much of the mystery and controversy about how resveratrol can indeed work in moderate doses.

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A New Hope for Newborns

When a 1.5-pound preemie had trouble breathing due to his undeveloped lungs, Charles G. Cochrane, MD, professor emeritus at TSRI, arrived at the hospital in time to see the baby receive a dose of Surfaxin® (lucinactant) – a drug Dr. Cochrane had spent two decades developing. Surfaxin®, approved in March 2012, has helped thousands of premature infants with respiratory distress syndrome breathe. Learn more about Dr. Cochrane's story.
facts & figures

Smoking-related illness in the United States costs more than $289 billion a year in medical care and lost productivity.
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