Better Health as We Age, Within Our Grasp
A Unique Effort to Extend Healthspan
Aging affects everyone, and few questions are more important than how we can age more healthfully. Researchers at The Scripps Research Institute (TSRI) are working to find ways to make healthy aging a possibility within the grasp of us all. TSRI has a track record of translating basic discoveries into new therapies. And TSRI has a department dedicated to research on aging – one of only a few in the nation focused on age-related metabolic changes. TSRI scientists are poised to develop new approaches to expand what some call our “healthspan.”
An Urgent Challenge
- Aging results in impaired function of all organs and tissues.
- Currently those over the age of 65 comprise the fastest growing segment of the world’s population. It is estimated that by 2030, there will be about 72.1 million people 65 or older in the US, more than twice their number in 2000.
- Aging is associated with a range of diseases and conditions, including coronary heart disease and stroke, cancer, Alzheimer’s, Parkinson’s, vision and hearing loss, osteoarthritis, osteoporosis and Type II diabetes.
The Need for Philanthropy
Despite the great need for research on aging, federal funding for basic biomedical research has declined by 30% in the last decade. The National Institutes of Health (NIH), the primary source for basic biomedical research funding in the US, favors lower-risk projects that can only impact medicine incrementally. Tackling aging requires high-risk, high-reward endeavors – the kind particularly difficult to fund through conventional government grants. Greatly expanded private support is needed to find new ways to extend our healthspan. As funding for vital research dwindles, we need your help!
Since aging affects all organs and is the number one risk factor for a variety of debilitating diseases, research on aging demands a team approach. TSRI cultivates an interdisciplinary spirit where chemists, biologists and others work hand-in-hand toward a common goal. Scientists specializing in a variety of approaches come together to synergistically address critical issues, shedding light on the underlying causes of aging and novel therapeutic targets for expanding healthspan.
Your support will enable us to expand personnel in critical areas and fund innovative research projects, so we can find breakthroughs in the shortest time possible. Add to that the federal funding that is sure to result from discoveries at TSRI due to this initiative, and together we will have an enormous impact on our generation and generations to come.
Potential healthy aging projects will be geared to:
- Discovering novel therapeutic and preventive strategies to extend healthspan including, adult stem cells, small molecule drug candidates, and natural products.
- Establishing the safety and efficacy of drug candidates.
- Developing early diagnostics of unhealthy aging.
Future discoveries will build on a strong track record of breakthroughs at TSRI, including, to name only a few:
- Identifying signaling pathways activated with aging that represent novel therapeutic targets.
- Finding therapeutic targets to prevent onset of metabolic syndrome—which raises the risk for heart disease, diabetes and stroke—during aging.
- Pioneering approaches for the treatment and prevention of osteoarthritis.
- Developing the use of adult stem cells for treating age-related diseases, including vision loss.
Please Join Us in the Fight for Cures
If you have a loved one who is facing chronic disease related to aging, you know that every discovery is crucial in the quest for cures. Gifts of all sizes are needed to make the next breakthrough a reality. Make a tax-deductible gift to TSRI and make a difference today!